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Archives of Virology
Published in: Archives of Virology 4/2009

01-04-2009 | Brief Report

A comparison of the pathogenicity of avian and swine H5N1 influenza viruses in Indonesia

Authors: Ryo Takano, Chairul A. Nidom, Maki Kiso, Yukiko Muramoto, Shinya Yamada, Kyoko Shinya, Yuko Sakai-Tagawa, Yoshihiro Kawaoka

Published in: Archives of Virology | Issue 4/2009

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Abstract

Highly pathogenic avian influenza H5N1 viruses are circulating in many countries. We recently discovered that these viruses have been transmitted to pigs on multiple occasions in Indonesia. To investigate whether avian H5N1 influenza viruses adapted to mammals through their introduction into pigs, we examined the growth of avian and swine isolates in cell culture and compared their pathogenicity in mice. We found that swine isolates were less virulent to mice than avian isolates, suggesting that the viruses became attenuated during their replication in pigs. Continuous surveillance of H5N1 viruses among pigs is clearly warranted.
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Metadata
Title
A comparison of the pathogenicity of avian and swine H5N1 influenza viruses in Indonesia
Authors
Ryo Takano
Chairul A. Nidom
Maki Kiso
Yukiko Muramoto
Shinya Yamada
Kyoko Shinya
Yuko Sakai-Tagawa
Yoshihiro Kawaoka
Publication date
01-04-2009
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 4/2009
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-009-0353-5

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