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Open Access 27-01-2024 | Parkinson's Disease | Neurology and Preclinical Neurological Studies - Original Article

Validation of the Italian version of the Parkinson’s Disease- Cognitive Functional Rating Scale

Authors: Michela Garon, Luca Weis, Antònia Siquier, Eleonora Fiorenzato, Francesca Pistonesi, Valeria Cianci, Margherita Canesi, Francesca Pesce, Elisa Reali, Beatrice Pozzi, Ioannis Ugo Isaias, Chiara Siri, Gabriella Santangelo, Sofia Cuoco, Paolo Barone, Jaime Kulisevsky, Angelo Antonini, Roberta Biundo

Published in: Journal of Neural Transmission | Issue 4/2024

Abstract

A key distinguishing factor between mild cognitive impairment (MCI) and dementia in Parkinson’s disease (PD) lies in the notable decrease in functioning due to cognitive impairment. The Parkinson’s Disease-Cognitive Functional Rating Scale (PD-CRFS) was developed to assess functional limitations caused by cognitive impairment, while reducing the influence of motor impairment. The aim of this multicenter study was to (i) validate the Italian version of the PD-CFRS in PD, (ii) determine optimal cut-off scores for detecting MCI and dementia in PD, (iii) compare its performances with the most established functional assessment tool (IADL). Six hundred and sixty nine PD participants were recruited from 4 Italian Movement Disorders centers (Venice, Milan, Gravedona, and Salerno). They underwent Level-II cognitive evaluation, which resulted in 282 PD-NC, 310 PD-MCI, and 77 PDD. The PD-CFRS’s psychometric and clinimetric properties, applicability, and responsiveness were analyzed. The PD-CFRS showed high acceptability. Floor and ceiling effects were acceptable. It also displayed strong internal consistency (Cronbach’s α = 0.738), and test–retest reliability (ICC = .854). The PD-CFRS demonstrated higher coefficient of variation to detect dysfunction in PD-MCI patients in comparison to the IADL scale (PD-CFRS 96% vs IADL 22.5%). Convergent validity with the IADL was r = − 0.638 and − 0.527 in males and females, respectively. PD-CFRS total score negatively correlated with global cognition (MoCA corrected score r = − 0.61; p < 0.001). A cut-off score > 6.5 identified PDD with a sensitivity of 90% and specificity of 88% (AUC = .959). A cut-off value of > 1 detected PD-MCI with a sensitivity of 68% and specificity of 69% (AUC = .695). The Italian version of the PD-CFRS demonstrated to be an easy, valid and reliable tool that properly captures functional impairment due to cognitive decline in PD. It also proved to be particularly effective in the advanced stages of PD, and would be a useful support for the diagnosis of PD-MCI and PDD.

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Title: Validation of the Italian version of the Parkinson’s Disease- Cognitive Functional Rating Scale
Authors: Michela Garon
Luca Weis
Antònia Siquier
Eleonora Fiorenzato
Francesca Pistonesi
Valeria Cianci
Margherita Canesi
Francesca Pesce
Elisa Reali
Beatrice Pozzi
Ioannis Ugo Isaias
Chiara Siri
Gabriella Santangelo
Sofia Cuoco
Paolo Barone
Jaime Kulisevsky
Angelo Antonini
Roberta Biundo
Publication date: 27-01-2024
Publisher: Springer Vienna
Keywords: Parkinson's Disease
Mild Cognitive Impairment
Dementia
Dementia
Published in: Journal of Neural Transmission / Issue 4/2024
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-024-02746-6

At a glance: The STEP trials

Springer Medicine

Validation of the Italian version of the Parkinson’s Disease- Cognitive Functional Rating Scale

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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