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01-09-2020 | Parkinson's Disease | Neurology and Preclinical Neurological Studies - Original Article

The intrinsically restructured fovea is correlated with contrast sensitivity loss in Parkinson’s disease

Authors: Elmar H. Pinkhardt, Yin Ding, Samantha Slotnick, Jan Kassubek, Albert C. Ludolph, Sofya Glazman, Ivan Selesnick, Ivan Bodis-Wollner

Published in: Journal of Neural Transmission | Issue 9/2020

Abstract

Foveal structure that is specified by the thickness, depth and the overall shape of the fovea is a promising tool to qualify and quantify retinal pathology in Parkinson’s disease. To determine the model variable that is best suited for discriminating Parkinson’s disease eyes from those of healthy controls and to assess correlations between impaired contrast sensitivity and foveal shape we characterized the fovea in 48 Parkinson’s disease patients and 45 control subjects by optical coherence tomography (OCT). The model quantifies structural changes in the fovea of Parkinson’s disease patients that are correlated with a decline in contrast sensitivity. Retinal foveal remodeling may serve as a parameter for vision deficits in Parkinson’s disease. Whether foveal remodeling reflects dopaminergic driven pathology or rather both dopaminergic and non-dopaminergic pathology has to be investigated in longitudinal studies.

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Title: The intrinsically restructured fovea is correlated with contrast sensitivity loss in Parkinson’s disease
Authors: Elmar H. Pinkhardt
Yin Ding
Samantha Slotnick
Jan Kassubek
Albert C. Ludolph
Sofya Glazman
Ivan Selesnick
Ivan Bodis-Wollner
Publication date: 01-09-2020
Publisher: Springer Vienna
Keyword: Parkinson's Disease
Published in: Journal of Neural Transmission / Issue 9/2020
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-020-02224-9

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The intrinsically restructured fovea is correlated with contrast sensitivity loss in Parkinson’s disease

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