Published in:
01-04-2019 | Levodopa | Editorial
Journal of Neural Transmission: a scientific journal devoted since 1950 to the translation of neuroscience into clinical practice
Authors:
Peter Riederer, Alois Sillaber, Neil Solomon, Etienne Hirsch, Christian Riederer
Published in:
Journal of Neural Transmission
|
Issue 4/2019
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Excerpt
In one of the most iconic experiments in neurology, Arvid Carlsson showed in the 1950s that rabbits were tranquilized after injections with the antipsychotic drug reserpine and that this state was reversed after they had received dl-DOPA. He published these results in a landmark Nature paper in 1957 and went on to conclude in the following years that l-DOPA would alleviate the syndromes of Parkinson´s disease. These findings earned him a share in the Nobel Prize in 2000, added a new chapter to the prospering CNS research activities in the 1950s and opened the gate for further investigations and ultimately the clinical investigation of the treatment of Parkinson´s disease in the 1960s. …
