Published in:
01-04-2019 | Neurology and Preclinical Neurological Studies - Review Article
Inhibitors of MAO-B and COMT: their effects on brain dopamine levels and uses in Parkinson’s disease
Author:
John P. M. Finberg
Published in:
Journal of Neural Transmission
|
Issue 4/2019
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Abstract
MAO-B and COMT are both enzymes involved in dopamine breakdown and metabolism. Inhibitors of these enzymes are used in the treatment of Parkinson’s disease. This review article describes the scientific background to the localization and function of the enzymes, the physiological changes resulting from their inhibition, and the basic and clinical pharmacology of the various inhibitors and their role in treatment of Parkinson’s disease.