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01-04-2019 | Parkinson's Disease | Neurology and Preclinical Neurological Studies - Review Article

Classical dopamine agonists

Authors: R. Horowski, P.-A. Löschmann

Published in: Journal of Neural Transmission | Issue 4/2019

Abstract

The pioneering work of Arvid Carlsson has laid the foundation for a number of innovative therapies for severe central nervous system (CNS) diseases. He was awarded the Nobel Price for the discovery of the crucial role of dopamine (DA) as a neurotransmitter in the CNS, thereby forming the basis for the symptomatic therapy of Parkinson’s disease (PD) with l-DOPA and subsequently dopaminergic drugs. Parenteral apomorphine has a short lasting effect in PD, bromocriptine can be administered orally and has a long-lasting effects but is poorly tolerated. Lisuride on the other hand has a high affinity to DA receptors and can be administered orally, parenterally or via the transdermal route of administration. Last but not least Carlsson developed the concepts of presynaptic effects of DA agonists as well as DA partial agonism potentially innovative mechanisms for treatment of PD and schizophrenia.

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Title: Classical dopamine agonists
Authors: R. Horowski
P.-A. Löschmann
Publication date: 01-04-2019
Publisher: Springer Vienna
Keywords: Parkinson's Disease
Levodopa
Dopamine Agonist
Bromocriptine
Lisuride
Apomorphine
Published in: Journal of Neural Transmission / Issue 4/2019
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-019-01989-y

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