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Published in: Journal of Neural Transmission 3/2019

Open Access 01-03-2019 | Affective Disorder | Psychiatry and Preclinical Psychiatric Studies - Review Article

The role of neurotrophins in psychopathology and cardiovascular diseases: psychosomatic connections

Authors: Andrea László, Lilla Lénárt, Lilla Illésy, Andrea Fekete, János Nemcsik

Published in: Journal of Neural Transmission | Issue 3/2019

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Abstract

Cardiovascular (CV) diseases and mood disorders are common public health problems worldwide. Their connections are widely studied, and the role of neurotrophins (NTs) is already supposed in both conditions. However, data in the literature of clinical aspects are sometimes controversial and no reviews are available describing possible associations between CV risk and mood disorders based on NTs. The mostly studied NT is brain-derived neurotrophic factor (BDNF). Decreased level of BDNF is observed in depression and its connection to hypertension has also been demonstrated with affecting the arterial baroreceptors, renin–angiotensin system and endothelial nitric oxide synthase. BDNF was also found to be the predictor of CV outcome in different patient populations. Other types of human NT-s, such as nerve growth factor, neurotrophin 3 and neurotrophin 4 also seem to have both psychopathological and CV connections. Our aim was to overview the present knowledge in this area, demonstrating a new aspect of the associations between mood disorders and CV diseases through the mediation of NTs. These findings might enlighten new psychosomatic connections and suggest new therapeutic targets that are beneficial both in respect of mood disorders and CV pathology.
Literature
go back to reference Abe T, Morgan DA, Gutterman DD (1997) Protective role of nerve growth factor against postischemic dysfunction of sympathetic coronary innervation. Circulation 95:213–220CrossRefPubMed Abe T, Morgan DA, Gutterman DD (1997) Protective role of nerve growth factor against postischemic dysfunction of sympathetic coronary innervation. Circulation 95:213–220CrossRefPubMed
go back to reference Ali MR, Abo-Youssef AM, Messiha BA, Khattab MM (2016) Tempol and perindopril protect against lipopolysaccharide-induced cognition impairment and amyloidogenesis by modulating brain-derived neurotropic factor, neuroinflammation and oxido-nitrosative stress. Naunyn Schmiedeberg’s Arch Pharmacol 389:637–656. https://doi.org/10.1007/s00210-016-1234-6 CrossRef Ali MR, Abo-Youssef AM, Messiha BA, Khattab MM (2016) Tempol and perindopril protect against lipopolysaccharide-induced cognition impairment and amyloidogenesis by modulating brain-derived neurotropic factor, neuroinflammation and oxido-nitrosative stress. Naunyn Schmiedeberg’s Arch Pharmacol 389:637–656. https://​doi.​org/​10.​1007/​s00210-016-1234-6 CrossRef
go back to reference Alleva E, Aloe L, Bigi S (1993) An updated role for nerve growth factor in neurobehavioural regulation of adult vertebrates. Rev Neurosci 4:41–62CrossRefPubMed Alleva E, Aloe L, Bigi S (1993) An updated role for nerve growth factor in neurobehavioural regulation of adult vertebrates. Rev Neurosci 4:41–62CrossRefPubMed
go back to reference Aloe L, Alleva E, Bohm A, Levi-Montalcini R (1986) Aggressive behavior induces release of nerve growth factor from mouse salivary gland into the bloodstream. Proc Natl Acad Sci USA 83:6184–6187CrossRefPubMedPubMedCentral Aloe L, Alleva E, Bohm A, Levi-Montalcini R (1986) Aggressive behavior induces release of nerve growth factor from mouse salivary gland into the bloodstream. Proc Natl Acad Sci USA 83:6184–6187CrossRefPubMedPubMedCentral
go back to reference Balkowiec A, Katz DM (2000) Activity-dependent release of endogenous brain-derived neurotrophic factor from primary sensory neurons detected by ELISA in situ. J Neurosci 20:7417–7423CrossRefPubMedPubMedCentral Balkowiec A, Katz DM (2000) Activity-dependent release of endogenous brain-derived neurotrophic factor from primary sensory neurons detected by ELISA in situ. J Neurosci 20:7417–7423CrossRefPubMedPubMedCentral
go back to reference Brady R, Zaidi SI, Mayer C, Katz DM (1999) BDNF is a target-derived survival factor for arterial baroreceptor and chemoafferent primary sensory neurons. J Neurosci 19:2131–2142CrossRefPubMedPubMedCentral Brady R, Zaidi SI, Mayer C, Katz DM (1999) BDNF is a target-derived survival factor for arterial baroreceptor and chemoafferent primary sensory neurons. J Neurosci 19:2131–2142CrossRefPubMedPubMedCentral
go back to reference Bu G, Sun Y, Schwartz AL, Holtzman DM (1998) Nerve growth factor induces rapid increases in functional cell surface low density lipoprotein receptor-related protein. J Biol Chem 273:13359–13365CrossRefPubMed Bu G, Sun Y, Schwartz AL, Holtzman DM (1998) Nerve growth factor induces rapid increases in functional cell surface low density lipoprotein receptor-related protein. J Biol Chem 273:13359–13365CrossRefPubMed
go back to reference Celada P, Siuciak JA, Tran TM, Altar CA, Tepper JM (1996) Local infusion of brain-derived neurotrophic factor modifies the firing pattern of dorsal raphe serotonergic neurons. Brain Res 712:293–298CrossRefPubMed Celada P, Siuciak JA, Tran TM, Altar CA, Tepper JM (1996) Local infusion of brain-derived neurotrophic factor modifies the firing pattern of dorsal raphe serotonergic neurons. Brain Res 712:293–298CrossRefPubMed
go back to reference da Penha Berzaghi M, Cooper J, Castren E, Zafra F, Sofroniew M, Thoenen H, Lindholm D (1993) Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus. J Neurosci 13:3818–3826CrossRefPubMedPubMedCentral da Penha Berzaghi M, Cooper J, Castren E, Zafra F, Sofroniew M, Thoenen H, Lindholm D (1993) Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus. J Neurosci 13:3818–3826CrossRefPubMedPubMedCentral
go back to reference Donovan MJ et al (1995) Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury. Am J Pathol 147:309–324PubMedPubMedCentral Donovan MJ et al (1995) Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury. Am J Pathol 147:309–324PubMedPubMedCentral
go back to reference Donovan MJ et al (2000) Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development 127:4531–4540PubMed Donovan MJ et al (2000) Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development 127:4531–4540PubMed
go back to reference Dugue B, Leppanen EA, Teppo AM, Fyhrquist F, Grasbeck R (1993) Effects of psychological stress on plasma interleukins-1 beta and 6, C-reactive protein, tumour necrosis factor alpha, anti-diuretic hormone and serum cortisol Scand. J Clin Lab Investig 53:555–561CrossRef Dugue B, Leppanen EA, Teppo AM, Fyhrquist F, Grasbeck R (1993) Effects of psychological stress on plasma interleukins-1 beta and 6, C-reactive protein, tumour necrosis factor alpha, anti-diuretic hormone and serum cortisol Scand. J Clin Lab Investig 53:555–561CrossRef
go back to reference Egan MF et al (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112:257–269CrossRefPubMed Egan MF et al (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112:257–269CrossRefPubMed
go back to reference Erickson JT, Conover JC, Borday V, Champagnat J, Barbacid M, Yancopoulos G, Katz DM (1996) Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing. J Neurosci 16:5361–5371CrossRefPubMedPubMedCentral Erickson JT, Conover JC, Borday V, Champagnat J, Barbacid M, Yancopoulos G, Katz DM (1996) Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing. J Neurosci 16:5361–5371CrossRefPubMedPubMedCentral
go back to reference Hajjar I et al (2005) Cross-sectional and longitudinal association between antihypertensive medications and cognitive impairment in an elderly population. J Gerontol A Biol Sci Med Sci 60:67–73CrossRefPubMed Hajjar I et al (2005) Cross-sectional and longitudinal association between antihypertensive medications and cognitive impairment in an elderly population. J Gerontol A Biol Sci Med Sci 60:67–73CrossRefPubMed
go back to reference Head RJ (1989) Hypernoradrenergic innervation: its relationship to functional and hyperplastic changes in the vasculature of the spontaneously hypertensive rat. Blood Vessels 26:1–20PubMed Head RJ (1989) Hypernoradrenergic innervation: its relationship to functional and hyperplastic changes in the vasculature of the spontaneously hypertensive rat. Blood Vessels 26:1–20PubMed
go back to reference Hiriart M, Vidaltamayo R, Sanchez-Soto MC (2001) Nerve and fibroblast growth factors as modulators of pancreatic beta cell plasticity and insulin secretion. Isr Med Assoc J 3:114–116PubMed Hiriart M, Vidaltamayo R, Sanchez-Soto MC (2001) Nerve and fibroblast growth factors as modulators of pancreatic beta cell plasticity and insulin secretion. Isr Med Assoc J 3:114–116PubMed
go back to reference Hock C, Heese K, Muller-Spahn F, Huber P, Riesen W, Nitsch RM, Otten U (2000) Increased cerebrospinal fluid levels of neurotrophin 3 (NT-3) in elderly patients with major depression. Mol Psychiatry 5:510–513CrossRefPubMed Hock C, Heese K, Muller-Spahn F, Huber P, Riesen W, Nitsch RM, Otten U (2000) Increased cerebrospinal fluid levels of neurotrophin 3 (NT-3) in elderly patients with major depression. Mol Psychiatry 5:510–513CrossRefPubMed
go back to reference Hyman C, Juhasz M, Jackson C, Wright P, Ip NY, Lindsay RM (1994) Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon. J Neurosci 14:335–347CrossRefPubMedPubMedCentral Hyman C, Juhasz M, Jackson C, Wright P, Ip NY, Lindsay RM (1994) Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon. J Neurosci 14:335–347CrossRefPubMedPubMedCentral
go back to reference Ip NY et al (1992) Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. Proc Natl Acad Sci USA 89:3060–3064CrossRefPubMedPubMedCentral Ip NY et al (1992) Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. Proc Natl Acad Sci USA 89:3060–3064CrossRefPubMedPubMedCentral
go back to reference Ip NY, Li Y, Yancopoulos GD, Lindsay RM (1993) Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not. NGF J Neurosci 13:3394–3405CrossRefPubMed Ip NY, Li Y, Yancopoulos GD, Lindsay RM (1993) Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not. NGF J Neurosci 13:3394–3405CrossRefPubMed
go back to reference Kang H, Schuman EM (1996) A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity. Science 273:1402–1406CrossRefPubMed Kang H, Schuman EM (1996) A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity. Science 273:1402–1406CrossRefPubMed
go back to reference Karege F, Schwald M, Cisse M (2002) Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci Lett 328:261–264CrossRefPubMed Karege F, Schwald M, Cisse M (2002) Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci Lett 328:261–264CrossRefPubMed
go back to reference Korosi B et al (2017) The impact of currently recommended antihypertensive therapy on depression and other psychometric parameters: preliminary communication. Neuropsychopharmacologia Hungarica: a Magyar Pszichofarmakologiai Egyesulet lapja 19:11–22 Korosi B et al (2017) The impact of currently recommended antihypertensive therapy on depression and other psychometric parameters: preliminary communication. Neuropsychopharmacologia Hungarica: a Magyar Pszichofarmakologiai Egyesulet lapja 19:11–22
go back to reference Maness LM, Kastin AJ, Weber JT, Banks WA, Beckman BS, Zadina JE (1994) The neurotrophins and their receptors: structure, function, and neuropathology. Neurosci Biobehav Rev 18:143–159CrossRefPubMed Maness LM, Kastin AJ, Weber JT, Banks WA, Beckman BS, Zadina JE (1994) The neurotrophins and their receptors: structure, function, and neuropathology. Neurosci Biobehav Rev 18:143–159CrossRefPubMed
go back to reference Martin-Iverson MT, Todd KG, Altar CA (1994) Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamine and serotonin metabolism and related behaviors: interactions with amphetamine. J Neurosci 14:1262–1270CrossRefPubMedPubMedCentral Martin-Iverson MT, Todd KG, Altar CA (1994) Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamine and serotonin metabolism and related behaviors: interactions with amphetamine. J Neurosci 14:1262–1270CrossRefPubMedPubMedCentral
go back to reference Messaoudi E, Ying SW, Kanhema T, Croll SD, Bramham CR (2002) Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo. J Neurosci 22:7453–7461CrossRefPubMedPubMedCentral Messaoudi E, Ying SW, Kanhema T, Croll SD, Bramham CR (2002) Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo. J Neurosci 22:7453–7461CrossRefPubMedPubMedCentral
go back to reference Mukherjee SP, Mukherjee C (1982) Similar activities of nerve growth factor and its homologue proinsulin in intracellular hydrogen peroxide production and metabolism in adipocytes. Transmembrane signalling relative to insulin-mimicking cellular effects. Biochem Pharmacol 31:3163–3172CrossRefPubMed Mukherjee SP, Mukherjee C (1982) Similar activities of nerve growth factor and its homologue proinsulin in intracellular hydrogen peroxide production and metabolism in adipocytes. Transmembrane signalling relative to insulin-mimicking cellular effects. Biochem Pharmacol 31:3163–3172CrossRefPubMed
go back to reference Ng TB, Wong CM (1985) Epidermal and nerve growth factors manifest antilipolytic and lipogenic activities in isolated rat adipocytes. Comp Biochem Physiol B 81:687–689CrossRefPubMed Ng TB, Wong CM (1985) Epidermal and nerve growth factors manifest antilipolytic and lipogenic activities in isolated rat adipocytes. Comp Biochem Physiol B 81:687–689CrossRefPubMed
go back to reference Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ (1998) Transport of brain-derived neurotrophic factor across the blood–brain barrier. Neuropharmacology 37:1553–1561CrossRefPubMed Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ (1998) Transport of brain-derived neurotrophic factor across the blood–brain barrier. Neuropharmacology 37:1553–1561CrossRefPubMed
go back to reference Penninx BW, Beekman AT, Honig A, Deeg DJ, Schoevers RA, van Eijk JT, van Tilburg W (2001) Depression and cardiac mortality: results from a community-based longitudinal study. Arch Gen Psychiatry 58:221–227CrossRefPubMed Penninx BW, Beekman AT, Honig A, Deeg DJ, Schoevers RA, van Eijk JT, van Tilburg W (2001) Depression and cardiac mortality: results from a community-based longitudinal study. Arch Gen Psychiatry 58:221–227CrossRefPubMed
go back to reference Poduslo JF, Curran GL (1996) Permeability at the blood–brain and blood–nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3 BDNF. Brain Res Mol Brain Res 36:280–286CrossRefPubMed Poduslo JF, Curran GL (1996) Permeability at the blood–brain and blood–nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3 BDNF. Brain Res Mol Brain Res 36:280–286CrossRefPubMed
go back to reference Rosso P, De Nicolo S, Carito V, Fiore M, Iannitelli A, Moreno S, Tirassa P (2017) Ocular nerve growth factor administration modulates brain-derived neurotrophic factor signaling in prefrontal cortex of healthy and diabetic rats. CNS Neurosci Therap 23:198–208. https://doi.org/10.1111/cns.12661 CrossRef Rosso P, De Nicolo S, Carito V, Fiore M, Iannitelli A, Moreno S, Tirassa P (2017) Ocular nerve growth factor administration modulates brain-derived neurotrophic factor signaling in prefrontal cortex of healthy and diabetic rats. CNS Neurosci Therap 23:198–208. https://​doi.​org/​10.​1111/​cns.​12661 CrossRef
go back to reference Salton SR (2003) Neurotrophins, growth-factor-regulated genes and the control of energy balance Mt. Sinai. J Med 70:93–100 Salton SR (2003) Neurotrophins, growth-factor-regulated genes and the control of energy balance Mt. Sinai. J Med 70:93–100
go back to reference Sariola H, Sainio K, Arumae U, Saarma M (1994) Neurotrophins and ciliary neurotrophic factor: their biology and pathology. Ann Med 26:355–363CrossRefPubMed Sariola H, Sainio K, Arumae U, Saarma M (1994) Neurotrophins and ciliary neurotrophic factor: their biology and pathology. Ann Med 26:355–363CrossRefPubMed
go back to reference Sauer H, Wong V, Bjorklund A (1995) Brain-derived neurotrophic factor and neurotrophin-4/5 modify neurotransmitter-related gene expression in the 6-hydroxydopamine-lesioned rat striatum. Neuroscience 65:927–933CrossRefPubMed Sauer H, Wong V, Bjorklund A (1995) Brain-derived neurotrophic factor and neurotrophin-4/5 modify neurotransmitter-related gene expression in the 6-hydroxydopamine-lesioned rat striatum. Neuroscience 65:927–933CrossRefPubMed
go back to reference Schecterson LC, Bothwell M (1992) Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons. Neuron 9:449–463CrossRefPubMed Schecterson LC, Bothwell M (1992) Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons. Neuron 9:449–463CrossRefPubMed
go back to reference Schutte A, Yan Q, Mestres P, Giehl KM (2000) The endogenous survival promotion of axotomized rat corticospinal neurons by brain-derived neurotrophic factor is mediated via paracrine, rather than autocrine mechanisms. Neurosci Lett 290:185–188CrossRefPubMed Schutte A, Yan Q, Mestres P, Giehl KM (2000) The endogenous survival promotion of axotomized rat corticospinal neurons by brain-derived neurotrophic factor is mediated via paracrine, rather than autocrine mechanisms. Neurosci Lett 290:185–188CrossRefPubMed
go back to reference Shimizu E et al (2003) Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 54:70–75CrossRefPubMed Shimizu E et al (2003) Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 54:70–75CrossRefPubMed
go back to reference Skaper SD (2008) The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors. CNS Neurol Disord Drug Targets 7:46–62CrossRefPubMed Skaper SD (2008) The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors. CNS Neurol Disord Drug Targets 7:46–62CrossRefPubMed
go back to reference Spitsbergen JM, Clemow DB, McCarty R, Steers WD, Tuttle JB (1998) Neurally mediated hyperactive voiding in spontaneously hypertensive rats. Brain Res 790:151–159CrossRefPubMed Spitsbergen JM, Clemow DB, McCarty R, Steers WD, Tuttle JB (1998) Neurally mediated hyperactive voiding in spontaneously hypertensive rats. Brain Res 790:151–159CrossRefPubMed
go back to reference Tessarollo L, Tsoulfas P, Donovan MJ, Palko ME, Blair-Flynn J, Hempstead BL, Parada LF (1997) Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis. Proc Natl Acad Sci USA 94:14776–14781CrossRefPubMedPubMedCentral Tessarollo L, Tsoulfas P, Donovan MJ, Palko ME, Blair-Flynn J, Hempstead BL, Parada LF (1997) Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis. Proc Natl Acad Sci USA 94:14776–14781CrossRefPubMedPubMedCentral
go back to reference Tuttle JB, Spitsbergen JM, Stewart JS, McCarty RM, Steers WD (1995) Altered signalling in vascular smooth muscle from spontaneously hypertensive rats may link medial hypertrophy, vessel hyperinnervation and elevated nerve growth factor. Clin Exp Pharmacol Physiol Suppl 22:S117–S119CrossRefPubMed Tuttle JB, Spitsbergen JM, Stewart JS, McCarty RM, Steers WD (1995) Altered signalling in vascular smooth muscle from spontaneously hypertensive rats may link medial hypertrophy, vessel hyperinnervation and elevated nerve growth factor. Clin Exp Pharmacol Physiol Suppl 22:S117–S119CrossRefPubMed
go back to reference Zafra F, Hengerer B, Leibrock J, Thoenen H, Lindholm D (1990) Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. EMBO J 9:3545–3550CrossRefPubMedPubMedCentral Zafra F, Hengerer B, Leibrock J, Thoenen H, Lindholm D (1990) Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. EMBO J 9:3545–3550CrossRefPubMedPubMedCentral
go back to reference Zafra F, Castren E, Thoenen H, Lindholm D (1991) Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons. Proc Natl Acad Sci USA 88:10037–10041CrossRefPubMedPubMedCentral Zafra F, Castren E, Thoenen H, Lindholm D (1991) Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons. Proc Natl Acad Sci USA 88:10037–10041CrossRefPubMedPubMedCentral
go back to reference Zettler C, Rush RA (1993) Elevated concentrations of nerve growth factor in heart and mesenteric arteries of spontaneously hypertensive rats. Brain Res 614:15–20CrossRefPubMed Zettler C, Rush RA (1993) Elevated concentrations of nerve growth factor in heart and mesenteric arteries of spontaneously hypertensive rats. Brain Res 614:15–20CrossRefPubMed
go back to reference Zhang SH, Rush RA (2001) Neurotrophin 3 is increased in the spontaneously hypertensive rat. J Hypertens 19:2251–2256CrossRefPubMed Zhang SH, Rush RA (2001) Neurotrophin 3 is increased in the spontaneously hypertensive rat. J Hypertens 19:2251–2256CrossRefPubMed
go back to reference Zoladz JA, Pilc A (2010) The effect of physical activity on the brain derived neurotrophic factor: from animal to human studies. J Physiol Pharmacol 61:533–541PubMed Zoladz JA, Pilc A (2010) The effect of physical activity on the brain derived neurotrophic factor: from animal to human studies. J Physiol Pharmacol 61:533–541PubMed
Metadata
Title
The role of neurotrophins in psychopathology and cardiovascular diseases: psychosomatic connections
Authors
Andrea László
Lilla Lénárt
Lilla Illésy
Andrea Fekete
János Nemcsik
Publication date
01-03-2019
Publisher
Springer Vienna
Published in
Journal of Neural Transmission / Issue 3/2019
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-019-01973-6

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