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Open Access 01-03-2019 | Psychiatry and Preclinical Psychiatric Studies - Short communication

The first identification of nesfatin-1-expressing neurons in the human bed nucleus of the stria terminalis

Authors: Artur Pałasz, Katarzyna Bogus, Aleksandra Suszka-Świtek, Andrzej Kaśkosz, Shirley Saint-Remy, Aneta Piwowarczyk-Nowak, Łukasz Filipczyk, John J. Worthington, Kinga Mordecka-Chamera, Karol Kostro, Grzegorz Bajor, Ryszard Wiaderkiewicz

Published in: Journal of Neural Transmission | Issue 3/2019

Abstract

Neuropeptides are involved in various brain activities being able to control a wide spectrum of higher mental functions. The purpose of this concise structural investigation was to detect the possible immunoreactivity of the novel multifunctional neuropeptide nesfatin-1 within the human bed nucleus of the stria terminalis (BNST). The BNST is involved in the mechanism of fear learning, integration of stress and reward circuits, and pathogenesis of addiction. Nesfatin-1-expressing neurons were identified for the first time in several regions of the BNST using both immunohistochemical and fluorescent methods. This may implicate a potential contribution of this neuropeptide to the BNST-related mechanisms of stress/reward responses in the human brain.

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Title: The first identification of nesfatin-1-expressing neurons in the human bed nucleus of the stria terminalis
Authors: Artur Pałasz
Katarzyna Bogus
Aleksandra Suszka-Świtek
Andrzej Kaśkosz
Shirley Saint-Remy
Aneta Piwowarczyk-Nowak
Łukasz Filipczyk
John J. Worthington
Kinga Mordecka-Chamera
Karol Kostro
Grzegorz Bajor
Ryszard Wiaderkiewicz
Publication date: 01-03-2019
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 3/2019
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-019-01984-3

At a glance: The STEP trials

Springer Medicine

The first identification of nesfatin-1-expressing neurons in the human bed nucleus of the stria terminalis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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