Top

Published in:

01-06-2018 | Neurology and Preclinical Neurological Studies - Short communication

Who will remain tremor dominant? The possible role of cognitive reserve in the time course of two common Parkinson’s disease motor subtypes

Authors: Talia Herman, S. Shema-Shiratzky, L. Arie, N. Giladi, J. M. Hausdorff

Published in: Journal of Neural Transmission | Issue 6/2018

Abstract

In a prospective 5-year study among Parkinson’s disease (PD) tremor-dominant (TD) patients, we investigated who will remain TD and who will later convert into the postural instability gait difficulty (PIGD) phenotype. At follow-up, 38% were still considered TD. At baseline the TD non-convertors had more years of education and better cognitive function than the convertors and significantly smaller deterioration in gait, balance, cognitive function and other non-motor symptoms. These results highlight the potential role of cognition in protecting against the development of PIGD symptoms.

Available only for authorised users

Alves G, Larsen JP, Emre M, Wentzel-Larsen T, Aarsland D (2006) Changes in motor subtype and risk for incident dementia in Parkinson’s disease. Mov Disord 21:1123–1130CrossRefPubMed

Arie L, Herman T, Shema-Shiratzky S, Giladi N, Hausdorff JM (2017) Do cognition and other non-motor symptoms decline similarly among patients with Parkinson’s disease motor subtypes? Findings from a 5-year prospective study. J Neurol 264:2149–2157

Burn DJ, Rowan EN, Allan LM, Molloy S, O’Brien JT, McKeith IG (2006) Motor subtype and cognitive decline in Parkinson’s disease, Parkinson’s disease with dementia, and dementia with Lewy bodies. J Neurol Neurosurg Psychiatry 77:585–589CrossRefPubMedPubMedCentral

Eisinger RS, Hess CW, Martinez-Ramirez D, Almeida L, Foote KD, Okun MS, Gunduz A (2017) Motor subtype changes in early Parkinson’s disease. Parkinsonism Relat Disord 43:66–72

Fereshtehnejad SM, Postuma RB (2017) Subtypes of Parkinson’s disease: what do they tell us about disease progression? Curr Neurol Neurosci Rep 17:34CrossRefPubMed

Hariz GM, Forsgren L (2011) Activities of daily living and quality of life in persons with newly diagnosed Parkinson’s disease according to subtype of disease, and in comparison to healthy controls. Acta Neurol Scand 123:20–27CrossRefPubMed

Jankovic J, Kapadia AS (2001) Functional decline in Parkinson disease. Arch Neurol 58:1611–1615CrossRefPubMed

Kotagal V (2016) Is PIGD a legitimate motor subtype in Parkinson disease? Ann Clin Transl Neurol 3:473–477CrossRefPubMedPubMedCentral

Nutt JG (2016) Motor subtype in Parkinson’s disease: different disorders or different stages of disease? Mov Disord 31:957–961CrossRefPubMed

Selikhova M, Kempster PA, Revesz T, Holton JL, Lees AJ (2013) Neuropathological findings in benign tremulous parkinsonism. Mov Disord 28:145–152CrossRefPubMed

Stern Y (2002) What is cognitive reserve? Theory and research application of the reserve concept. J Int Neuropsychol Soc 8:448–460CrossRefPubMed

Title: Who will remain tremor dominant? The possible role of cognitive reserve in the time course of two common Parkinson’s disease motor subtypes
Authors: Talia Herman
S. Shema-Shiratzky
L. Arie
N. Giladi
J. M. Hausdorff
Publication date: 01-06-2018
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 6/2018
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-018-1859-3

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Who will remain tremor dominant? The possible role of cognitive reserve in the time course of two common Parkinson’s disease motor subtypes

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 6/2018

Antidepressant treatment effects on dopamine transporter availability in patients with major depression: a prospective 123I-FP-CIT SPECT imaging genetic study

An observational study of rotigotine transdermal patch and other currently prescribed therapies in patients with Parkinson’s disease

Kynurenic acid and its derivatives are able to modulate the adhesion and locomotion of brain endothelial cells

COQ2 variants in Parkinson’s disease and multiple system atrophy

In vivo exploration of retinal nerve fiber layer morphology in Parkinson’s disease patients

Neuropathology and biochemistry of early onset familial Alzheimer’s disease caused by presenilin-1 missense mutation Thr116Asn