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01-02-2017 | Psychiatry and Preclinical Psychiatric Studies - Review Article

The role of sleep problems and circadian clock genes in attention-deficit hyperactivity disorder and mood disorders during childhood and adolescence: an update

Authors: Alexander Dueck, Christoph Berger, Katharina Wunsch, Johannes Thome, Stefan Cohrs, Olaf Reis, Frank Haessler

Published in: Journal of Neural Transmission | Special Issue 1/2017

Abstract

A more recent branch of research describes the importance of sleep problems in the development and treatment of mental disorders in children and adolescents, such as attention-deficit hyperactivity disorder (ADHD) and mood disorders (MD). Research about clock genes has continued since 2012 with a focus on metabolic processes within all parts of the mammalian body, but particularly within different cerebral regions. Research has focused on complex regulatory circuits involving clock genes themselves and their influence on circadian rhythms of diverse body functions. Current publications on basic research in human and animal models indicate directions for the treatment of mental disorders targeting circadian rhythms and mechanisms. The most significant lines of research are described in this paper.

Abou-Khadra MK, Amin OR, Shaker OG, Rabah TM (2013) Parent-reported sleep problems, symptom ratings, and serum ferritin levels in children with attention-deficit/hyperactivity disorder: a case control study. BMC Pediatr 13:217CrossRefPubMedPubMedCentral

Alexiuk NA, Vriend J (2007) Melatonin: effects on dopaminergic and serotonergic neurons of the caudate nucleus of the striatum of male Syrian hamsters. J Neural Transm 114:549–554CrossRefPubMed

Alvaro PK, Roberts RM, Harris JK (2014) The independent relationships between insomnia, depression, subtypes of anxiety, and chronotype during adolescence. Sleep Med 15(8):934–941. doi:10.1016/j.sleep.2014.03.019 CrossRefPubMed

APA, Diagnostic and statistical manual of mental disorders (DSM-V), vol. 5th ed. 2013, Washington

Astill RG, Van der Heijden KB, Van Ijzendoorn MH, Van Someren EJ (2012) Sleep, cognition, and behavioral problems in school-age children: a century of research meta-analyzed. Psychol Bull 138:1109–1138CrossRefPubMed

Augustinavicius JL, Zanjani A, Zakzanis KK, Shapiro CM (2014) Polysomnographic features of early-onset depression: a meta-analysis. J Affect Disord 158:11–18CrossRefPubMed

Baird AL, Coogan AN, Kaufling J, Barrot M, Thome J (2013) Daily methylphenidate and atomoxetine treatment impacts on clock gene protein expression in the mouse brain. Brain Res 1513:61–71CrossRefPubMed

Barkley RA, Fischer M (2010) The unique contribution of emotional impulsiveness to impairment in major life activities in hyperactive children as adults. J Am Acad Child Adolesc Psychiatry 49:503–513PubMed

Bedrosian TA, Nelson RJ (2013) Influence of the modern light environment on mood. Mol Psychiatry 18(7):751–757. doi:10.1038/mp.2013.70

Blomeyer D, Buchmann AF, Lascorz J, Zimmermann US, Esser G, Desrivieres S, Schmidt MH, Banaschewski T, Schumann G, Laucht M (2013) Association of PER2 genotype and stressful life events with alcohol drinking in young adults. PLoS ONE 8:e59136CrossRefPubMedPubMedCentral

Bonaconsa M, Malpeli G, Montaruli A, Carandente F, Grassi-Zucconi G, Bentivoglio M (2014) Differential modulation of clock gene expression in the suprachiasmatic nucleus, liver and heart of aged mice. Exp Gerontol 55:70–79CrossRefPubMed

Brotman MA, Rich BA, Guyer AE, Lunsford JR, Horsey SE, Reising MM, Thomas LA, Fromm SJ, Towbin K, Pine DS, Leibenluft E (2010) Amygdala activation during emotion processing of neutral faces in children with severe mood dysregulation versus ADHD or bipolar disorder. Am J Psychiatry 167:61–69CrossRefPubMed

Bush G, Valera EM, Seidman LJ (2005) Functional neuroimaging of attention-deficit/hyperactivity disorder: a review and suggested future directions. Biol Psychiatry 57:1273–1284CrossRefPubMed

Chung S, Lee EJ, Yun S, Choe HK, Park SB, Son HJ, Kim KS, Dluzen DE, Lee I, Hwang O, Son GH, Kim K (2014) Impact of circadian nuclear receptor REV-ERBa on midbrain dopamine production and mood regulation. Cell 157(4):858–868. doi:10.1016/j CrossRefPubMed

Combs K, Smith PJ, Sherwood A, Hoffman B, Carney RM, Freedland K, Craighead WE, Blumenthal JA (2014) Impact of sleep complaints and depression outcomes among participants in the standard medical intervention and long-term exercise study of exercise and pharmacotherapy for depression. J Nerv Ment Dis 202:167–171CrossRefPubMed

Connor DF, Ford JD (2012) Comorbid symptom severity in attention-deficit/hyperactivity disorder: a clinical study. J Clin Psychiatry 73:711–717CrossRefPubMed

Coogan AN, Papachatzaki MM, Clemens C, Baird A, Donev RM, Joosten J, Zachariou V, Thome J (2011) Haloperidol alters circadian clock gene product expression in the mouse brain. World J Biol Psychiatry 12:638–644CrossRefPubMed

Cortese S (2013) Review: recommendations for the assessment and management of sleep disorders in ADHD. Evid Based, Mental Health 17

de Souza CM, Hidalgo MP, (2014) Midpoint of sleep on school days is associated with depression among adolescents. Chronobiol Int 31(2):199–205. doi: 10.3109/07420528.2013.838575

Dillon JE, Chervin RD (2012) ADHD and sleep disorders in children: A Quick Primer for Clinicians. Psychiatric Times

Don Richardson J, Cyr KS, Nelson C, Elhai JD, Sareen J (2014) Sleep disturbances and suicidal ideation in a sample of treatment-seeking Canadian Forces members and veterans. Psychiatry Res 218:118–123CrossRefPubMed

Donato AJ, Lesniewski LA, Stuart D, Walker AE, Henson G, Sorensen L, Li D, Kohan DE (2014) Smooth muscle specific disruption of the endothelin-A receptor in mice reduces arterial pressure, and vascular reactivity and affects vascular development. Life Sci 118(2):238–243. doi:10.1016/j.lfs.2013.12.209

Dueck A, Thome J, Haessler F (2012) The role of sleep problems and circadian clock genes in childhood psychiatric disorders. J Neural Transm 119:1097–1104CrossRefPubMed

Duncan MJ, Smith JT, Franklin KM, Beckett TL, Murphy MP, St Clair DK, Donohue KD, Striz M, O’Hara BF (2012) Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer’s disease. Exp Neurol 236:249–258CrossRefPubMed

Emens J, Lewy A, Kinzie JM, Arntz D, Rough D (2009) Circadian misalignment in major depressive disorder. Psychiatry Res 168(3):259–261. doi:10.1016/j.psychres.2009.04.009 CrossRefPubMed

Fattinger S, Jenni OG, Schmitt B, Achermann P, Huber R (2014) Overnight changes in the slope of sleep slow waves during infancy. Sleep 37:245–253PubMedPubMedCentral

Fujihara Y, Kondo H, Noguchi T, Togari A (2014) Glucocorticoids mediate circadian timing in peripheral osteoclasts resulting in the circadian expression rhythm of osteoclast-related genes. Bone 61:1–9CrossRefPubMed

Galland BC, Tripp EG, Taylor BJ (2010) The sleep of children with attention deficit hyperactivity disorder on and off methylphenidate: a matched case-control study. J Sleep Res 19:366–373CrossRefPubMed

Glozier N, O’Dea B, McGorry PD, Pantelis C, Hermens GP, Amminger DF, Purcell R, Scott E, Hickie IB (2014) Delayed sleep onset in depressed young people. BMC Psychiatry 14:33CrossRefPubMedPubMedCentral

Goldstein TR, Bridge JA, Brent DA (2008) Sleep disturbance preceding completed suicide in adolescents. J Consult Clin Psychol 76:84–91CrossRefPubMedPubMedCentral

Gonzalez R, Tamminga C, Tohen M, Suppes T (2013) Comparison of objective and subjective assessments of sleep time in subjects with bipolar disorder. J Affect Disord 149:363–366CrossRefPubMed

Griesauer I, Diao W, Ronovsky M, Elbau I, Sartori S, Singewald N, Pollak DD (2013) Circadian abnormalities in a mouse model of high trait anxiety and depression. Ann Med 46:148–154CrossRef

Guillaumond F, Dardente H, Giguere V, Cermakian N (2005) Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors. J Biol Rhythms 20:391–403CrossRefPubMed

Han DH, Lee YJ, Kim K, Kim CJ, Cho S (2014) Modulation of glucocorticoid receptor induction properties by core circadian clock proteins. Mol Cell Endocrinol 383:170–180CrossRefPubMed

Hansen BH, Skirbekk B, Oerbeck B, Wentzel-Larsen T, Kristensen H (2014) Associations between sleep problems and attentional and behavioral functioning in children with anxiety disorders and ADHD. Behav Sleep Med 12:53–68CrossRefPubMed

Harbour VL, Weigl Y, Robinson B, Amir S (2014) Phase differences in expression of circadian clock genes in the central nucleus of the amygdala, dentate gyrus, and suprachiasmatic nucleus in the rat. PLoS ONE 9:e103309CrossRefPubMedPubMedCentral

Hardeland R, Poeggeler B (2012) Melatonin and synthetic melatonergic agonists: actions and metabolism in the central nervous system. Cent Nerv Syst Agents Med Chem 12:189–216CrossRefPubMed

Hasler BP, Buysse DJ, Kupfer DJ, Germain A (2010) Phase relationships between core body temperature, melatonin, and sleep are associated with depression severity: further evidence for circadian misalignment in non-seasonal depression. Psychiatry Res; 178(1):205–7 [Research Support, NIH, Extramural Research Support, Non-US Gov’t]

Herrmann MJ, Biehl SC, Jacob C, Deckert J (2010) Neurobiological and psychophysiological correlates of emotional dysregulation in ADHD patients. Atten Defic Hyperact Disord 2:233–239CrossRefPubMed

Houdek P, Polidarová L, Nováková M, Matějů K, Kubík Š, Sumová A (2014) Melatonin administered during the fetal stage affects circadian clock in the suprachiasmatic nucleus but not in the liver. Dev Neurobiol 75(2):131–144. doi:10.1002/dneu.22213

Hua P, Liu W, Chen D, Zhao Y, Chen L, Zhang N, Wang C, Guo S, Wang L, Xiao H, Kuo SH (2013) Cry1 and Tef gene polymorphisms are associated with major depressive disorder in the Chinese population. J Affect Disord 157:100–103CrossRefPubMedPubMedCentral

Huang J, Zhong Z, Wang M, Chen X, Tan Y, Zhang S, He W, He X, Huang G, Lu H, Wu P, Che Y, Yan YL, Postlethwait JH, Chen W, Wang H (2015) Circadian modulation of dopamine levels and dopaminergic neuron development contributes to attention deficiency and hyperactive behavior. J Neurosci. Feb 11;35(6):2572–87. doi:10.1523/JNEUROSCI.2551-14.2015

Huber R, Born J (2013) Sleep, synaptic connectivity, and hippocampal memory during early development. Trends Cogn Sci 18:141–152CrossRef

Hussain MM, Pan X (2014) Circadian regulators of intestinal lipid absorption. J Lipid Res 56(4):761–770. doi:10.1194/jlr.R051573

Isayama K, Chen H, Yamauchi N, Hattori MA (2014) REV-ERBalpha inhibits the PTGS2 expression in bovine uterus endometrium stromal and epithelial cells exposed to ovarian steroids. J Reprod Dev 60(5):362–370

Kahn M, Sheppes G, Sadeh A (2013) Sleep and emotions: bidirectional links and underlying mechanisms. Int J Psychophysiol 89:218–228CrossRefPubMed

Kober H, Barrett LF, Joseph J, Bliss-Moreau E, Lindquist K, Wager TD (2008) Functional grouping and cortical-subcortical interactions in emotion: a meta-analysis of neuroimaging studies. Neuroimage 42:998–1031CrossRefPubMedPubMedCentral

Kozakai, T,Sakate, M,Takizawa, S,Uchide, T,Kobayashi, H,Oishi, K,Ishida, N,Saida, K, (2014) Effect of feeding behavior on circadian regulation of endothelin expression in mouse colon. Life Sci

Kudlow PA, Cha DS, Lam RW, McIntyre RS (2013) Sleep architecture variation: a mediator of metabolic disturbance in individuals with major depressive disorder. Sleep Med 14:943–949CrossRefPubMed

Lai YC, Huang MC, Chen HC, Lu MK, Chiu YH, Shen WW, Lu RB, Kuo PH (2014) Familiality and clinical outcomes of sleep disturbances in major depressive and bipolar disorders. J Psychosom Res 76:61–67CrossRefPubMed

Landgraf D, McCarthy MJ, Welsh DK (2014) The role of the circadian clock in animal models of mood disorders. Behav Neurosci 128:344–359CrossRefPubMed

Li JZ, Bunney BG, Meng F, Hagenauer MH, Walsh DM, Vawter MP, Evans SJ, Choudary PV, Cartagena P, Barchas JD, Schatzberg AF, Jones EG, Myers RM, Watson SJ Jr, Akil H, Bunney WE (2013) Circadian patterns of gene expression in the human brain and disruption in major depressive disorder. Proc Natl Acad Sci USA 110:9950–9955CrossRefPubMedPubMedCentral

Lycett K, Sciberras E, Mensah FK, Hiscock H (2014) Behavioral sleep problems and internalizing and externalizing comorbidities in children with attention-deficit/hyperactivity disorder. Eur Child Adolesc Psychiatry

Maciukiewicz M, Dmitrzak-Weglarz M, Pawlak J, Leszczynska-Rodziewicz A, Zaremba D, Skibinska M, Hauser J (2014) Analysis of genetic association and epistasis interactions between circadian clock genes and symptom dimensions of bipolar affective disorder. Chronobiol Int 31:770–778CrossRefPubMed

Martin-Fairey CA, Nunez AA (2014) Circadian modulation of memory and plasticity gene products in a diurnal species. Brain Res

McCarthy MJ, Nievergelt CM, Kelsoe JR, Welsh DK (2012) A survey of genomic studies supports association of circadian clock genes with bipolar disorder spectrum illnesses and lithium response. PLoS ONE 7:e32091CrossRefPubMedPubMedCentral

Meszaros K, Pruess L, Szabo AJ, Gondan M, Ritz E, Schaefer F (2014) Development of the circadian clockwork in the kidney. Kidney Int

Mews MR, Rombold F, Quante A (2014) Efficacy and safety of low-dose doxepin in depressed patients suffering from insomnia: a retrospective, naturalistic case series analysis. Prim Care Companion CNS Disord 16:

Miano S (2013) Introduction to the special section on sleep and ADHD. J Att Disord 17:547–549CrossRef

Molina-Carballo A, Naranjo-Gomez A, Uberos J, Justicia-Martinez F, Ruiz-Ramos MJ, Cubero-Millan I, Contreras-Chova F, Augustin-Morales MD, Khaldy-Belkadi H, Munoz-Hoyos A (2013) Methylphenidate effects on blood serotonin and melatonin levels may help to synchronise biological rhythms in children with ADHD. J Psychiatr Res 47:377–383CrossRefPubMed

Montgomery P, Wiggs L (2014) Definitions of sleeplessness in children with attention-deficit hyperactivity disorder (ADHD): implications for mothers’ mental state, daytime sleepiness and sleep-related cognitions. Child Care Health Dev

Moreau V, Rouleau N, Morin CM (2013) Sleep, attention, and executive functioning in children with attention-deficit/hyperactivity disorder. Arch Clin Neuropsychol 28:692–699CrossRefPubMed

Moriya S, Tahara Y, Sasaki H, Hamaguchi Y, Kuriki D, Ishikawa R, Ishigooka J, Shibata S (2014) Effect of quetiapine on per1, per2, and bmal1 clock gene expression in the mouse amygdala and hippocampus. J Pharmacol Sci 125:329–332CrossRefPubMed

Mulder C, Van Der Zee EA, Hut RA, Gerkema MP (2013) Time-place learning and memory persist in mice lacking functional Per1 and Per2 clock genes. J Biol Rhythms 28:367–379CrossRefPubMed

Musiek ES, Lim MM, Yang G, Bauer AQ, Qi L, Lee Y, Roh JH, Ortiz-Gonzalez X, Dearborn JT, Culver JP, Herzog ED, Hogenesch JB, Wozniak DF, Dikranian K, Giasson BI, Weaver DR, Holtzman DM, Fitzgerald GA (2013) Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest 123:5389–5400CrossRefPubMedPubMedCentral

Naismith SL, Hermens DF, Ip TKC, Bolitho S, Scott E, Rogers NL, Hickie IB (2012) Circadian profiles in young people during the early stages of affective disorder. Transl Psychiatry 2:e123. doi:10.1038/tp.2012.47 CrossRefPubMedPubMedCentral

Nakatani M, Okada S, Shimizu S, Mohri I, Ohno Y, Taniike M, Makikawa M (2013) Body movement analysis during sleep for children with ADHD using video image processing. Conf Proc IEEE Eng Med Biol Soc 2013:6389–6392PubMed

Noh JY, Han DH, Kim MH, Ko IG, Kim SE, Park N, Kyoung Choe H, Kim KH, Kim K, Kim CJ, Cho S (2014) Presence of multiple peripheral circadian oscillators in the tissues controlling voiding function in mice. Exp Mol Med 46:e81CrossRefPubMedPubMedCentral

Norra C, Richter N (2013) Sleep disturbances and suicidality: relationships and clinical implications. Fortschr Neurol Psychiatr 81:561–569CrossRefPubMed

O’Keeffe SM, Thome J, Coogan AN (2012) The noradrenaline reuptake inhibitor atomoxetine phase-shifts the circadian clock in mice. Neuroscience 201:219–230CrossRefPubMed

Olini N, Huber R (2014) Diurnal changes in electrocorticogram sleep slow-wave activity during development in rats. J Sleep Res 23:261–267CrossRefPubMed

Owens JA, Spirito A, McGuinn M (2000) The Children’s sleep habits questionnaire (CSHQ): psychometric properties of a survey instrument for school-aged children. Sleep 23:1043–1051PubMed

Pail G, Huf W, Pjrek E, Winkler D, Willeit M, Praschak-Rieder N, Kasper S (2011) Bright-light therapy in the treatment of mood disorders. Neuropsychobiology 64:152–162CrossRefPubMed

Paterson JL, Dorrian J, Ferguson SA, Jay SM, Lamond N, Murphy PJ, Campbell SS, Dawson D (2011) Changes in structural aspects of mood during 39-66 h of sleep loss using matched controls. Appl Ergon 42:196–201CrossRefPubMed

Patten SB, Wang JL, Williams JV, Currie S, Beck CA, Maxwell CJ, El-Guebaly N (2006) Descriptive epidemiology of major depression in Canada. Can J Psychiatry 51:84–90CrossRefPubMed

Pellicciari MC, Cordone S, Marzano C, Bignotti S, Gazzoli A, Miniussi C, De Gennaro L (2013) Dorsolateral prefrontal transcranial magnetic stimulation in patients with major depression locally affects alpha power of REM sleep. Front Hum Neurosci 7:433CrossRefPubMedPubMedCentral

Plessen KJ, Bansal R, Zhu H, Whiteman R, Amat J, Quackenbush GA, Martin L, Durkin K, Blair C, Royal J, Hugdahl K, Peterson BS (2006) Hippocampus and amygdala morphology in attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 63:795–807CrossRefPubMedPubMedCentral

Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA (2007) The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry 164:942–948CrossRefPubMed

Pompili M, Innamorati M, Forte A, Longo L, Mazzetta C, Erbuto D, Ricci F, Palermo M, Stefani H, Seretti ME, Lamis DA, Perna G, Serafini G, Amore M, Girardi P (2013) Insomnia as a predictor of high-lethality suicide attempts. Int J Clin Pract 67:1311–1316CrossRefPubMed

Prehn-Kristensen A, Munz M, Molzow I, Wilhelm I, Wiesner CD, Baving L (2013) Sleep promotes consolidation of emotional memory in healthy children but not in children with attention-deficit hyperactivity disorder. PLoS ONE 8:e65098CrossRefPubMedPubMedCentral

Raboni MR, Alonso FF, Tufik S, Suchecki D (2014) Improvement of mood and sleep alterations in posttraumatic stress disorder patients by eye movement desensitization and reprocessing. Front Behav Neurosci 8:209CrossRefPubMedPubMedCentral

Rakai BD, Chrusch MJ, Spanswick SC, Dyck RH, Antle MC (2014) Survival of adult generated hippocampal neurons is altered in circadian arrhythmic mice. PLoS ONE 9:e99527CrossRefPubMedPubMedCentral

Rath MF, Rovsing L, Moller M (2014) Circadian oscillators in the mouse brain: molecular clock components in the neocortex and cerebellar cortex. Cell Tissue Res

Rawashdeh O, Jilg A, Jedlicka P, Slawska J, Thomas L, Saade A, Schwarzacher SW, Stehle JH (2014) PERIOD1 coordinates hippocampal rhythms and memory processing with daytime. Hippocampus 24:712–723CrossRefPubMed

Ren Z, Qiu A (2014) Sleep-related breathing disorder is associated with hyperactivity in preschoolers. Singapore Med J 55:257–260CrossRefPubMedPubMedCentral

Reppert SM, Weaver DR (2002) Coordination of circadian timing in mammals. Nature 418:935–941CrossRefPubMed

Richards J, Welch AK, Barilovits SJ, All S, Cheng, KY, Wingo CS, Cain BD, Gumz ML (2014) Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1. Life Sci

Richards J, Ko B, All S, Cheng KY, Hoover RS, Gumz ML (2014) A role for the circadian clock protein Per1 in the regulation of the NaCl co-transporter (NCC) and the with-no-lysine kinase (WNK) cascade in mouse distal convoluted tubule cells. J Biol Chem 289:11791–11806CrossRefPubMedPubMedCentral

Ringli M, Souissi S, Kurth S, Brandeis D, Jenni OG, Huber R (2013) Topography of sleep slow wave activity in children with attention-deficit/hyperactivity disorder. Cortex 49:340–347CrossRefPubMed

Robert JJ, Hoffmann RF, Emslie GJ, Hughes C, Rintelmann J, Moore J, Armitage R (2006) Sex and age differences in sleep macroarchitecture in childhood and adolescent depression. Sleep 29:351–358PubMed

Robillard R, Naismith SL, Rogers NL, Ip TKC, Hermens DF, Scott EM, Hickie IB (2013a) Delayed sleep phase in young people with unipolar or bipolar affective disorders. J Affect Disord 145(2):260–263. doi:10.1016/j.jad.2012.06.006

Robillard R, Naismith SL, Rogers NL, Scott EM, Ip TKC, Hermens DF, Hickie IB (2013b) Sleep-wake cycle and melatonin rhythms in adolescents and young adults with mood disorders: Comparison of unipolar and bipolar phenotypes. Eur Psychiatry 28(7):412–416. doi:10.1016/j.eurpsy.2013.04.001

Robillard R, Naismith SL, Smith KL, Rogers NL,White D, Terpening Z, Ip TKC, Hermens DF, Whitwell B, Scott EM, Hickie IB (2014) Sleep-wake cycle in young and older persons with a lifetime history of mood disorders. PLoS ONE 9(2): e87763. doi:10.1371/journal.pone.0087763

Rubin RT, Heist EK, McGeoy SS, Hanada K, Lesser IM (1992) Neuroendocrine Aspects of Primary Endogenous Depression: XI. Serum Melatonin Measures in Patients and Matched Control Subjects. Arch Gen Psychiatry 49(7):558–567. doi:10.1001/archpsyc.1992.01820070052008 CrossRefPubMed

Rybakowski JK, Dmitrzak-Weglarz M, Dembinska-Krajewska D, Hauser J, Akiskal KK, Akiskal HH (2014) Polymorphism of circadian clock genes and temperamental dimensions of the TEMPS-A in bipolar disorder. J Affect Disord 159:80–84CrossRefPubMed

Sato TK, Yamada RG, Ukai H, Baggs JE, Miraglia LJ, Kobayashi TJ, Welsh DK, Kay SA, Ueda HR, Hogenesch JB (2006) Feedback repression is required for mammalian circadian clock function. Nat Genet 38:312–319CrossRefPubMedPubMedCentral

Schnell A, Chappuis S, Schmutz I, Brai E, Ripperger JA, Schaad O, Welzl H, Descombes P, Alberi L, Albrecht U (2014) The nuclear receptor REV-ERBalpha regulates Fabp7 and modulates adult hippocampal neurogenesis. PLoS ONE 9:e99883CrossRefPubMedPubMedCentral

Sedky K, Bennett DS, Carvalho KS (2013) Attention deficit hyperactivity disorder and sleep disordered breathing in pediatric populations: a meta-analysis. Sleep Med Rev 18:349–356CrossRefPubMed

Short MA, Gradisar M, Lack LC, Wright HR (2013) The impact of sleep on adolescent depressed mood, alertness and academic performance. J Adolesc 36(6):1025–1033. doi:10.1016/j.adolescence.2013.08.007

Shu L, Sulaiman AH, Huang YS, Fones Soon Leng C, Crutel VS, Kim YS (2013) Comparable efficacy and safety of 8 weeks treatment with agomelatine 25–50 mg or fluoxetine 20–40 mg in Asian out-patients with major depressive disorder. Asian J Psychiatr 8:26–32CrossRefPubMed

Simons A, Eyskens F, De Groof A, Van Diest E, Deboutte D, Vermeiren R (2006) Cognitive functioning and psychiatric disorders in children with a metabolic disease. Eur Child Adolesc Psychiatry 15:207–213CrossRefPubMed

Sivertsen B, Harvey AG, Pallesen S, Hysing M (2014) Mental health problems in adolescents with delayed sleep phase: results from a large population-based study in Norway. J Sleep Res 24:11–18

Tahmasian M, Knight DC, Manoliu A, Schwerthoffer D, Scherr M, Meng C, Shao J, Peters H, Doll A, Khazaie H, Drzezga A, Bauml J, Zimmer C, Forstl H, Wohlschlager AM, Riedl V, Sorg C (2013) Aberrant intrinsic connectivity of hippocampus and amygdala overlap in the fronto-insular and dorsomedial-prefrontal cortex in major depressive disorder. Front Hum Neurosci 7:639CrossRefPubMedPubMedCentral

Takahashi K, Yamada T, Tsukita S, Kaneko K, Shirai Y, Munakata Y, Ishigaki Y, Imai J, Uno K, Hasegawa Y, Sawada S, Oka Y, Katagiri H (2012) Chronic mild stress alters circadian expressions of molecular clock genes in the liver. Am J Physiol Endocrinol Metab 304:E301–E309CrossRefPubMed

Tonetti L, Fabbri M, Erbacci A, Martoni M, Natale V (2014) Association between seasonal affective disorder and subjective quality of the sleep/wake cycle in adolescents. Psychiatry Res 215(3):624–627. doi:10.1016/j.psychres.2013.12.023

Van der Heijden KB, Smits MG, Van Someren EJ, Gunning WB (2005) Idiopathic chronic sleep onset insomnia in attentiondeficit/hyperactivity disorder: a circadian rhythm sleep disorder. Chronobiol Int 22:559–570CrossRefPubMed

van der Meer D, Hartman CA, Richards J, Bralten JB, Franke B, Oosterlaan J, Heslenfeld DJ, Faraone SV, Buitelaar JK, Hoekstra PJ (2014) The serotonin transporter gene polymorphism 5-HTTLPR moderates the effects of stress on attention-deficit/hyperactivity disorder. J Child Psychol Psychiatry

Van Veen MM, Kooij JJ, Boonstra AM, Gordijn MC, Van Someren EJ (2010) Delayed circadian rhythm in adults with attentiondeficit/hyperactivity disorder and chronic sleep-onset insomnia. Biol Psychiatry 67:1091–1096CrossRefPubMed

Vandekerckhove M, Kestemont J, Weiss R, Schotte C, Exadaktylos V, Haex B, Verbraecken J, Gross JJ (2012) Experiential versus analytical emotion regulation and sleep: breaking the link between negative events and sleep disturbance. Emotion 12:1415–1421CrossRefPubMed

Vanderlind WM, Beevers CG, Sherman SM, Trujillo LT, McGeary JE, Mathews MD, Maddox MT, Schnyer DM (2014) Sleep and sadness: exploring the relation among sleep, cognitive control, and depressive symptoms in young adults. Sleep Med 15(1):144–149. doi:10.1016/j.sleep.2013.10.006 CrossRefPubMed

Weber M, Webb CA, Deldonno SR, Kipman M, Schwab ZJ, Weiner MR, Killgore WD (2013) Habitual ‘sleep credit’ is associated with greater grey matter volume of the medial prefrontal cortex, higher emotional intelligence and better mental health. J Sleep Res 22:527–534CrossRefPubMed

Wu JC, Kelsoe JR, Schachat C, Bunney BG, DeModena A, Golshan S, Gillin JC, Potkin SG, Bunney WE (2009) Rapid and sustained antidepressant response with sleep deprivation and chronotherapy in bipolar disorder. Biol Psychiatry 66:298–301CrossRefPubMed

Zambrano-Sanchez E, Martinez-Cortes JA, Dehesa-Moreno M, del Rio-Carlos Y, Poblano A (2013) Correlation between sleep disorder screening and executive dysfunction in children with attention deficit-hyperactivity disorder. Arq Neuropsiquiatr 71:896–901CrossRefPubMed

Zhang R, Lahens NF, Ballance HI, Hughes ME, Hogenescha JB (2014) A circadian gene expression atlas in mammals: Implications for biology and medicine. Proc Natl Acad Sci USA 111(45):16219–16224. doi:10.1073/pnas.1408886111

Title: The role of sleep problems and circadian clock genes in attention-deficit hyperactivity disorder and mood disorders during childhood and adolescence: an update
Authors: Alexander Dueck
Christoph Berger
Katharina Wunsch
Johannes Thome
Stefan Cohrs
Olaf Reis
Frank Haessler
Publication date: 01-02-2017
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue Special Issue 1/2017
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-015-1455-8

ACC 2024 Congress

Springer Medicine

The role of sleep problems and circadian clock genes in attention-deficit hyperactivity disorder and mood disorders during childhood and adolescence: an update

Abstract

ACC 2024 Congress

Springer Medicine

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