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01-02-2017 | Psychiatry and Preclinical Psychiatric Studies - Review article

How does healthy aging impact on the circadian clock?

Authors: Aurel Popa-Wagner, Ana-Maria Buga, Dinu Iuliu Dumitrascu, Adriana Uzoni, Johannes Thome, Andrew N. Coogan

Published in: Journal of Neural Transmission | Special Issue 1/2017

Abstract

Circadian rhythms are recurring patterns in a host of physiological and other parameters that recur with periods of near 24 h. These rhythms reflect the temporal organization of an organism’s homeostatic control systems and as such are key processes in ensuring optimal physiological performance. Dysfunction of circadian processes is linked with adverse health conditions. In this review we highlight the evidence that normal, healthy aging is associated with changes in the circadian system; we examine the molecular mechanisms through which such changes may arise, discuss whether more robust circadian function is a predictor of longevity and highlight the role of circadian rhythms in age-related diseases. Overall, the literature shows that aging is associated with marked changes in circadian processes, both at the behavioral and molecular levels, and the molecular mechanisms through which such changes arise remain to be elucidated, but may involve inflammatory process, redox homeostasis and epigenetic modifications. Understanding the nature of age-related circadian dysfunction will allow for the design of chronotherapeutic intervention strategies to attenuate circadian dysfunction and thus improve health and quality of life.

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Title: How does healthy aging impact on the circadian clock?
Authors: Aurel Popa-Wagner
Ana-Maria Buga
Dinu Iuliu Dumitrascu
Adriana Uzoni
Johannes Thome
Andrew N. Coogan
Publication date: 01-02-2017
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue Special Issue 1/2017
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-015-1424-2

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