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01-08-2011 | Movement Disorders -Short Communication

Extranigral extension of structural midbrain lesions overshadows parkinsonism

Authors: Hee Jin Kim, Ji Young Yun, Jong-Min Kim, Yu Kyeong Kim, Gwanhee Erm, Sang Eun Kim, Beom S. Jeon

Published in: Journal of Neural Transmission | Issue 8/2011

Abstract

We report on a clinicoanatomical analysis of five patients with structural midbrain lesions who shared severe nigrostriatal dopaminergic denervation but presented different involuntary movements. The main clinical phenotype was parkinsonism in only one case; it was choreoballism in three cases and tremor and dystonia in one case. Structural midbrain lesions are likely to involve structures additional to nigral dopaminergic neurons. The extent of extranigral involvement may determine the diverse clinical manifestations associated with the structural midbrain lesions.

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Title: Extranigral extension of structural midbrain lesions overshadows parkinsonism
Authors: Hee Jin Kim
Ji Young Yun
Jong-Min Kim
Yu Kyeong Kim
Gwanhee Erm
Sang Eun Kim
Beom S. Jeon
Publication date: 01-08-2011
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 8/2011
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-011-0584-y

At a glance: The STEP trials

Springer Medicine

Extranigral extension of structural midbrain lesions overshadows parkinsonism

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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