Skip to main content
Top
Published in: Journal of Neural Transmission 9/2009

01-09-2009 | Basic Neurosciences, Genetics and Immunology - Short Communication

Hemispheric lateralization of the corticostriatal glutamatergic system in the rat

Authors: Christine Capper-Loup, Dominik Rebell, Alain Kaelin-Lang

Published in: Journal of Neural Transmission | Issue 9/2009

Login to get access

Abstract

Little is known about hemispheric lateralization of subcortical structures. Here, we show a higher expression of the subunit NR2A of the NMDA receptor mRNA in the striatum and of vGluT1 mRNA in the cingulate cortex, in the left hemisphere compared to the right one. This suggests a lateralization of the glutamatergic cortico-subcortical system, at the level of postsynaptic receptors as well as at the level of corticostriatal projections. Such lateralization could play a role in asymmetric diseases like Parkinson’s disease.
Literature
go back to reference Albin RL, Young AB, Penney JB (1989) The functional anatomy of basal ganglia disorders. Trends Neurosci 12:366–375PubMedCrossRef Albin RL, Young AB, Penney JB (1989) The functional anatomy of basal ganglia disorders. Trends Neurosci 12:366–375PubMedCrossRef
go back to reference Alexander GE, Crutcher MD (1990) Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends Neurosci 13:266–271PubMedCrossRef Alexander GE, Crutcher MD (1990) Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends Neurosci 13:266–271PubMedCrossRef
go back to reference Betarbet R, Poisik O, Sherer TB, Greenamyre JT (2004) Differential expression and ser897 phosphorylation of striatal N-methyl-d-aspartate receptor subunit NR1 in animal models of Parkinson’s disease. Exp Neurol 187:76–85PubMedCrossRef Betarbet R, Poisik O, Sherer TB, Greenamyre JT (2004) Differential expression and ser897 phosphorylation of striatal N-methyl-d-aspartate receptor subunit NR1 in animal models of Parkinson’s disease. Exp Neurol 187:76–85PubMedCrossRef
go back to reference Broca P (1865) Sur la faculte du langage articule. Bull Soc Anat Paris 6:493–494 Broca P (1865) Sur la faculte du langage articule. Bull Soc Anat Paris 6:493–494
go back to reference Buller AL, Larson HC, Schneider BE, Beaton JA, Morrisett RA, Monaghan DT (1994) The molecular basis of NMDA receptor subtypes: native receptor diversity is predicted by subunit composition. J Neurosci 14:5471–5484PubMed Buller AL, Larson HC, Schneider BE, Beaton JA, Morrisett RA, Monaghan DT (1994) The molecular basis of NMDA receptor subtypes: native receptor diversity is predicted by subunit composition. J Neurosci 14:5471–5484PubMed
go back to reference Capper-Loup C, Kaelin-Lang A (2008) Lateralization of dynorphin gene expression in the rat striatum. Neurosci Lett 447:106–108PubMedCrossRef Capper-Loup C, Kaelin-Lang A (2008) Lateralization of dynorphin gene expression in the rat striatum. Neurosci Lett 447:106–108PubMedCrossRef
go back to reference Carlsson M, Carlsson A (1990) Interactions between glutamatergic and monoaminergic systems within the basal ganglia—implications for schizophrenia and Parkinson’s disease. Trends Neurosci 13:272–276PubMedCrossRef Carlsson M, Carlsson A (1990) Interactions between glutamatergic and monoaminergic systems within the basal ganglia—implications for schizophrenia and Parkinson’s disease. Trends Neurosci 13:272–276PubMedCrossRef
go back to reference Diamond MC (1991) Hormonal effects on the development or cerebral lateralization. Psychoneuroendocrinology 16:121–129PubMedCrossRef Diamond MC (1991) Hormonal effects on the development or cerebral lateralization. Psychoneuroendocrinology 16:121–129PubMedCrossRef
go back to reference Dingledine R, Borges K, Bowie D, Traynelis SF (1999) The glutamate receptor ion channels. Pharmacol Rev 51:7–61PubMed Dingledine R, Borges K, Bowie D, Traynelis SF (1999) The glutamate receptor ion channels. Pharmacol Rev 51:7–61PubMed
go back to reference Dube L, Smith AD, Bolam JP (1988) Identification of synaptic terminals of thalamic or cortical origin in contact with distinct medium-size spiny neurons in the rat neostriatum. J Comp Neurol 267:455–471PubMedCrossRef Dube L, Smith AD, Bolam JP (1988) Identification of synaptic terminals of thalamic or cortical origin in contact with distinct medium-size spiny neurons in the rat neostriatum. J Comp Neurol 267:455–471PubMedCrossRef
go back to reference Dunah AW, Wang Y, Yasuda RP, Kameyama K, Huganir RL, Wolfe BB, Standaert DG (2000) Alterations in subunit expression, composition, and phosphorylation of striatal N-methyl-d-aspartate glutamate receptors in a rat 6-hydroxydopamine model of Parkinson’s disease. Mol Pharmacol 57:342–352PubMed Dunah AW, Wang Y, Yasuda RP, Kameyama K, Huganir RL, Wolfe BB, Standaert DG (2000) Alterations in subunit expression, composition, and phosphorylation of striatal N-methyl-d-aspartate glutamate receptors in a rat 6-hydroxydopamine model of Parkinson’s disease. Mol Pharmacol 57:342–352PubMed
go back to reference Geschwind DH, Miller BL (2001) Molecular approaches to cerebral laterality: development and neurodegeneration. Am J Med Genet 101:370–381PubMedCrossRef Geschwind DH, Miller BL (2001) Molecular approaches to cerebral laterality: development and neurodegeneration. Am J Med Genet 101:370–381PubMedCrossRef
go back to reference Graybiel AM (1990) Neurotransmitters and neuromodulators in the basal ganglia. Trends Neurosci 13:244–254PubMedCrossRef Graybiel AM (1990) Neurotransmitters and neuromodulators in the basal ganglia. Trends Neurosci 13:244–254PubMedCrossRef
go back to reference Graybiel AM, Aosaki T, Flaherty AW, Kimura M (1994) The basal ganglia and adaptive motor control. Science 265:1826–1831PubMedCrossRef Graybiel AM, Aosaki T, Flaherty AW, Kimura M (1994) The basal ganglia and adaptive motor control. Science 265:1826–1831PubMedCrossRef
go back to reference Johnston AN, Rogers LJ, Dodd PR (1995) [3H]MK-801 binding asymmetry in the IMHV region of dark-reared chicks is reversed by imprinting. Brain Res Bull 37:5–8PubMedCrossRef Johnston AN, Rogers LJ, Dodd PR (1995) [3H]MK-801 binding asymmetry in the IMHV region of dark-reared chicks is reversed by imprinting. Brain Res Bull 37:5–8PubMedCrossRef
go back to reference Kaelin-Lang A, Liniger P, Probst A, Lauterburg T, Burgunder JM (2000) Adenosine A2A receptor gene expression in the normal striatum and after 6-OH-dopamine lesion. J Neural Transm 107:851–859PubMedCrossRef Kaelin-Lang A, Liniger P, Probst A, Lauterburg T, Burgunder JM (2000) Adenosine A2A receptor gene expression in the normal striatum and after 6-OH-dopamine lesion. J Neural Transm 107:851–859PubMedCrossRef
go back to reference Kornhuber J, Mack-Burkhardt F, Riederer P (1989) Regional distribution of [3H]MK-801 binding sites in the human brain. Brain Res 489:397–399PubMedCrossRef Kornhuber J, Mack-Burkhardt F, Riederer P (1989) Regional distribution of [3H]MK-801 binding sites in the human brain. Brain Res 489:397–399PubMedCrossRef
go back to reference Kuppenbender KD, Standaert DG, Feuerstein TJ, Penney JB Jr, Young AB, Landwehrmeyer GB (2000) Expression of NMDA receptor subunit mRNAs in neurochemically identified projection and interneurons in the human striatum. J Comp Neurol 419:407–421PubMedCrossRef Kuppenbender KD, Standaert DG, Feuerstein TJ, Penney JB Jr, Young AB, Landwehrmeyer GB (2000) Expression of NMDA receptor subunit mRNAs in neurochemically identified projection and interneurons in the human striatum. J Comp Neurol 419:407–421PubMedCrossRef
go back to reference Luo J, Wang Y, Yasuda RP, Dunah AW, Wolfe BB (1997) The majority of N-methyl-d-aspartate receptor complexes in adult rat cerebral cortex contain at least three different subunits (NR1/NR2A/NR2B). Mol Pharmacol 51:79–86PubMed Luo J, Wang Y, Yasuda RP, Dunah AW, Wolfe BB (1997) The majority of N-methyl-d-aspartate receptor complexes in adult rat cerebral cortex contain at least three different subunits (NR1/NR2A/NR2B). Mol Pharmacol 51:79–86PubMed
go back to reference McGeorge AJ, Faull RL (1989) The organization of the projection from the cerebral cortex to the striatum in the rat. Neuroscience 29:503–537PubMedCrossRef McGeorge AJ, Faull RL (1989) The organization of the projection from the cerebral cortex to the striatum in the rat. Neuroscience 29:503–537PubMedCrossRef
go back to reference Parent A, Hazrati LN (1995) Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop. Brain Res Rev 20:91–127PubMedCrossRef Parent A, Hazrati LN (1995) Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop. Brain Res Rev 20:91–127PubMedCrossRef
go back to reference Standaert DG, Friberg IK, Landwehrmeyer GB, Young AB, Penney JB Jr (1999) Expression of NMDA glutamate receptor subunit mRNAs in neurochemically identified projection and interneurons in the striatum of the rat. Mol Brain Res 64:11–23PubMedCrossRef Standaert DG, Friberg IK, Landwehrmeyer GB, Young AB, Penney JB Jr (1999) Expression of NMDA glutamate receptor subunit mRNAs in neurochemically identified projection and interneurons in the striatum of the rat. Mol Brain Res 64:11–23PubMedCrossRef
go back to reference Ulas J, Cotman CW (1996) Dopaminergic denervation of striatum results in elevated expression of NR2A subunit. Neuroreport 7:1789–1793PubMedCrossRef Ulas J, Cotman CW (1996) Dopaminergic denervation of striatum results in elevated expression of NR2A subunit. Neuroreport 7:1789–1793PubMedCrossRef
go back to reference Yamaguchi M, Suzuki T, Abe S, Hori T, Kurita H, Asada T, Okado N, Arai H (2002) Repeated cocaine administration differentially affects NMDA receptor subunit (NR1, NR2A-C) mRNAs in rat brain. Synapse 46:157–169PubMedCrossRef Yamaguchi M, Suzuki T, Abe S, Hori T, Kurita H, Asada T, Okado N, Arai H (2002) Repeated cocaine administration differentially affects NMDA receptor subunit (NR1, NR2A-C) mRNAs in rat brain. Synapse 46:157–169PubMedCrossRef
Metadata
Title
Hemispheric lateralization of the corticostriatal glutamatergic system in the rat
Authors
Christine Capper-Loup
Dominik Rebell
Alain Kaelin-Lang
Publication date
01-09-2009
Publisher
Springer Vienna
Published in
Journal of Neural Transmission / Issue 9/2009
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-009-0265-2

Other articles of this Issue 9/2009

Journal of Neural Transmission 9/2009 Go to the issue

Basic Neurosciences, Genetics and Immunology - Original Article

Neuroprotective effects of probenecid in a transgenic animal model of Huntington’s disease