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Acta Neurochirurgica
Published in: Acta Neurochirurgica 5/2018

Open Access 01-05-2018 | Case Report - Brain Tumors

Ectopic Cushing’s syndrome secondary to olfactory neuroblastoma

Authors: Kenny Yu, Federico Roncaroli, Tara Kearney, David Ewins, Deepa Beeharry, Thomas Naylor, David Ray, Rajiv Bhalla, Kanna Gnanalingham

Published in: Acta Neurochirurgica | Issue 5/2018

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Abstract

We present the case of a patient with Cushing’s syndrome secondary to ectopic ACTH secretion. A MR of the head showed a left-sided nasal mass extending down from the cribriform plate. The patient underwent endoscopic resection with nearly complete removal of the mass. Histological examination showed an ACTH-secreting olfactory neuroblastoma (ONB). The patient’s cortisol levels returned to normal range after surgery and have remained normal for over a year. ONB is a rare cause for ectopic ACTH secretion. This case highlights the diagnostic and management difficulties in patients with ectopic ACTH secretion, and provides a brief review of ONB.
Literature
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Koo BK, An JH, Jeon KH, Choi SH, Cho YM, Jang HC, Chung JH, Lee CH, Lim S (2008) Two cases of ectopic adrenocorticotropic hormone syndrome with olfactory neuroblastoma and literature review. Endocr J 55:469–475CrossRefPubMed
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Monaghan PJ, Kyriacou A, Sturgeon C, Davies A, Trainer PJ, White A, Higham CE (2016) Proopiomelanocortin interference in the measurement of adrenocorticotrophic hormone: a United Kingdom National External Quality Assessment Service study. Clin Endocrinol 85:569–574. https://​doi.​org/​10.​1111/​cen.​13118 CrossRef
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Metadata
Title
Ectopic Cushing’s syndrome secondary to olfactory neuroblastoma
Authors
Kenny Yu
Federico Roncaroli
Tara Kearney
David Ewins
Deepa Beeharry
Thomas Naylor
David Ray
Rajiv Bhalla
Kanna Gnanalingham
Publication date
01-05-2018
Publisher
Springer Vienna
Published in
Acta Neurochirurgica / Issue 5/2018
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-017-3447-y

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