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01-12-2017 | Case Report - Brain Tumors

Differentiating brain radionecrosis from tumour recurrence: a role for contrast-enhanced ultrasound?

Authors: Luca Mattei, Francesco Prada, Marcello Marchetti, Paola Gaviani, Francesco DiMeco

Published in: Acta Neurochirurgica | Issue 12/2017

Abstract

Differentiating radionecrosis from tumour recurrence is a major issue in neuro-oncology. Conventional imaging is far from being validated as an alternative to histological assessment. We report the case of a patient operated on for suspected recurrence of brain metastasis 9 months after cyberknife radiosurgery. While magnetic resonance imaging showed strong enhancement of the lesion, intraoperative contrast-enhanced ultrasonography (CEUS) surprisingly did not—different from what is expected for brain metastases. Histopathological examination documented radionecrosis. For the first time, we describe radionecrosis with CEUS; further investigation is needed; however, the lack of enhancement could represent an important hallmark in differential diagnosis with neoplastic tissue.

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Title: Differentiating brain radionecrosis from tumour recurrence: a role for contrast-enhanced ultrasound?
Authors: Luca Mattei
Francesco Prada
Marcello Marchetti
Paola Gaviani
Francesco DiMeco
Publication date: 01-12-2017
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 12/2017
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-017-3306-x

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Differentiating brain radionecrosis from tumour recurrence: a role for contrast-enhanced ultrasound?

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