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Acta Neurochirurgica

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01-06-2016 | Clinical Article - Brain Tumors

Impact of tumor location and fourth ventricle infiltration in medulloblastoma

Authors: Tao Jiang, Yuqi Zhang, Junmei Wang, Jiang Du, Zhenyu Ma, Chunde Li, Raynald Liu, Yazhuo Zhang

Published in: Acta Neurochirurgica | Issue 6/2016

Abstract

Background

Medulloblastoma is the most common intracranial malignancy in children; with comprehensive treatment the 5-year overall survival (OS) is now greater than 80 %. Only few studies have addressed the relation of tumor location with patient’s prognosis. Based on experiences in our institution, we further classified the tumor location. This study aimed to investigate the impact of tumor location and fourth ventricle infiltration in medulloblastoma (MB) prognosis.

Methods

We retrospectively followed all MB patients at the Beijing Tiantan Hospital between 2004 and 2007 to investigate treatment outcomes and prognostic factors in MB patients. The data of 119 patients were collected. Tumor removal was performed in all patients, and all patients received postsurgical radiotherapy or chemotherapy. The patients were subclassified into three subtypes according to tumor location and tumor infiltration into the fourth ventricular floor (V4 floor). The prognostic factors were analyzed using Kaplan-Meier and Cox regression analysis.

Results

The median follow-up period was 75 months (range, 6–127 months). A total of 65 patients experienced recurrence or progression, and 56 patients were still alive at the time of follow-up. The 5-year progression-free survival (PFS) and overall survival (OS) rates were 47.1 ± 4.6 % and 54.6 ± 4.6 %, respectively.

Conclusions

According to the multivariate analysis, large cell and anaplastic (LC/A) subtype, patient age, and metastasis were found to be independent prognostic factors. Tumors with V4 floor infiltration exhibited a trend toward recurrence (P = 0.054). This investigation is the largest single-institution study of MB cases in China. The LC/A subtype, patient age, and metastasis were important prognostic factors. V4 floor infiltration was correlated with metastasis and younger age.

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Title: Impact of tumor location and fourth ventricle infiltration in medulloblastoma
Authors: Tao Jiang
Yuqi Zhang
Junmei Wang
Jiang Du
Zhenyu Ma
Chunde Li
Raynald Liu
Yazhuo Zhang
Publication date: 01-06-2016
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 6/2016
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-016-2779-3

At a glance: The STEP trials

Springer Medicine

Impact of tumor location and fourth ventricle infiltration in medulloblastoma

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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