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Acta Neurochirurgica
Published in: Acta Neurochirurgica 5/2016

01-05-2016 | Experimental Research - Functional

Effects of quercetin on chronic constriction nerve injury in an experimental rat model

Authors: Soner Çivi, Gökçen Emmez, Ümit Akın Dere, Alp Özgün Börcek, Hakan Emmez

Published in: Acta Neurochirurgica | Issue 5/2016

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Abstract

Background

Flavonoids are popular substances in the literature, with proven effects on cardiovascular, neoplastic and neurodegenerative diseases. Antioxidant effect is the most pronounced and studied one. Among thousands of flavonoids, quercetin (QUE) is a prototype with significant antioxidant effects. This study aims to demonstrate the effects of QUE in an experimental rat model of chronic constriction injury (CCI).

Method

A two-level study was designed with 42 adult Wistar rats that were randomly assigned to different groups. In the first part, animals in sham, control, quercetin, morphine and gabapentine groups received chronic constriction injury to their sciatic nerves and received a single dose of QUE, morphine and gabapentine. In the second part, different dose regimens of QUE were administered to different groups of animals. Pre-injury and post-injury assessments for mechanical hypersensitivity, thermal sensitivity, locomotor activity and anxiety were recorded and statistical comparisons were performed between different groups.

Results

Comparison of QUE with morphine and gabapentine has revealed significant effects of this agent in the current chronic constriction injury model. QUE was significantly superior to Gabapentine and morphine in terms of alleviating mechanical and thermal hypersensitivity. Additionally, pre-injury administration of QUE for 4 days demonstrated long-term effectiveness on mechanical hypersensitivity.

Conclusions

This preliminary report the on effects of QUE in a chronic constriction injury model proved significant effects of the agent, which should be supplemented with different studies using different dose regimens.
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Metadata
Title
Effects of quercetin on chronic constriction nerve injury in an experimental rat model
Authors
Soner Çivi
Gökçen Emmez
Ümit Akın Dere
Alp Özgün Börcek
Hakan Emmez
Publication date
01-05-2016
Publisher
Springer Vienna
Published in
Acta Neurochirurgica / Issue 5/2016
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-016-2761-0

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