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Published in: Surgery Today 12/2020

01-12-2020 | Cholecystitis | Original Article

Identification of risk factors for open conversion from laparoscopic cholecystectomy for acute cholecystitis based on computed tomography findings

Authors: Ryosuke Hirohata, Tomoyuki Abe, Hironobu Amano, Keiji Hanada, Tsuyoshi Kobayashi, Hideki Ohdan, Toshio Noriyuki, Masahiro Nakahara

Published in: Surgery Today | Issue 12/2020

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Abstract

Purpose

Laparoscopic cholecystectomy (LC) is performed widely for acute cholecystitis (AC). This study was conducted to identify the predictors for conversion cholecystectomy (CC) for AC.

Methods

The subjects of this study were 395 patients who underwent emergency surgery for AC between 2011 and 2019. Univariate and multivariate analyses were performed to establish the significance of the risk factors for CC in patients with grades II and III AC.

Results

There were 162 TG18 GII and GIII patients in the LC group and 31 in the CC group. Univariate analysis revealed significant differences in performance status (p = 0.039), C-reactive protein levels (p = 0.016), albumin levels (p = 0.002), gallbladder (GB) wall thickness (p = 0.045), poor contrast of the GB wall (p = 0.035), severe inflammation around the GB (p < 0.001), enhancement of the liver bed (p = 0.048), and duodenal edema (p < 0.001) between the groups. Multivariate analysis identified hypoalbuminemia (p = 0.043) and duodenal edema (p = 0.014) as independent risk factors for CC.

Conclusions

Most patients with grade I AC underwent LC and had better surgical outcomes than those with grades II and III AC. The most appropriate surgical procedure should be selected based on preoperative imaging of the GB and the neighboring organs and by the presence of hypoalbuminemia.
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Literature
1.
go back to reference Lau H, Lo CY, Patil NG, Yuen WK. Early versus delayed-interval laparoscopic cholecystectomy for acute cholecystitis: a meta-analysis. Surg Endosc. 2006;20:82–7.CrossRef Lau H, Lo CY, Patil NG, Yuen WK. Early versus delayed-interval laparoscopic cholecystectomy for acute cholecystitis: a meta-analysis. Surg Endosc. 2006;20:82–7.CrossRef
2.
go back to reference Kiviluoto T, Siren J, Luukkonen P, Kivilaakso E. Randomised trial of laparoscopic versus open cholecystectomy for acute and gangrenous cholecystitis. Lancet. 1998;351:321–5.CrossRef Kiviluoto T, Siren J, Luukkonen P, Kivilaakso E. Randomised trial of laparoscopic versus open cholecystectomy for acute and gangrenous cholecystitis. Lancet. 1998;351:321–5.CrossRef
3.
go back to reference Honda G, Iwanaga T, Kurata M, Watanabe F, Satoh H, Iwasaki K. The critical view of safety in laparoscopic cholecystectomy is optimized by exposing the inner layer of the subserosal layer. J Hepatobiliary Pancreat Surg. 2009;16:445–9.CrossRef Honda G, Iwanaga T, Kurata M, Watanabe F, Satoh H, Iwasaki K. The critical view of safety in laparoscopic cholecystectomy is optimized by exposing the inner layer of the subserosal layer. J Hepatobiliary Pancreat Surg. 2009;16:445–9.CrossRef
4.
go back to reference Wiesen SM, Unger SW, Barkin JS, Edelman DS, Scott JS, Unger HM. Laparoscopic cholecystectomy: the procedure of choice for acute cholecystitis. Am J Gastroenterol. 1993;88:334–7.PubMed Wiesen SM, Unger SW, Barkin JS, Edelman DS, Scott JS, Unger HM. Laparoscopic cholecystectomy: the procedure of choice for acute cholecystitis. Am J Gastroenterol. 1993;88:334–7.PubMed
5.
go back to reference Coccolini F, Catena F, Pisano M, Gheza F, Fagiuoli S, Di Saverio S, et al. Open versus laparoscopic cholecystectomy in acute cholecystitis. Syst Rev Meta-anal Int J Surg. 2015;18:196–204. Coccolini F, Catena F, Pisano M, Gheza F, Fagiuoli S, Di Saverio S, et al. Open versus laparoscopic cholecystectomy in acute cholecystitis. Syst Rev Meta-anal Int J Surg. 2015;18:196–204.
6.
go back to reference Coffin SJ, Wrenn SM, Callas PW, Abu-Jaish W. Three decades later: investigating the rate of and risks for conversion from laparoscopic to open cholecystectomy. Surg Endosc. 2018;32:923–9.CrossRef Coffin SJ, Wrenn SM, Callas PW, Abu-Jaish W. Three decades later: investigating the rate of and risks for conversion from laparoscopic to open cholecystectomy. Surg Endosc. 2018;32:923–9.CrossRef
7.
go back to reference Morgenstern L, Wong L, Berci G. Twelve hundred open cholecystectomies before the laparoscopic era. A standard for comparison. Arch Surg. 1992;127:400–3.CrossRef Morgenstern L, Wong L, Berci G. Twelve hundred open cholecystectomies before the laparoscopic era. A standard for comparison. Arch Surg. 1992;127:400–3.CrossRef
8.
go back to reference Ibrahim Y, Radwan RW, Abdullah AAN, Sherif M, Khalid U, Ansell J, et al. A retrospective and prospective study to develop a pre-operative difficulty score for laparoscopic cholecystectomy. J Gastrointest Surg. 2019;23:690–5.CrossRef Ibrahim Y, Radwan RW, Abdullah AAN, Sherif M, Khalid U, Ansell J, et al. A retrospective and prospective study to develop a pre-operative difficulty score for laparoscopic cholecystectomy. J Gastrointest Surg. 2019;23:690–5.CrossRef
9.
go back to reference Griffiths EA, Hodson J, Vohra RS, Marriott P, Katbeh T, Zino S, et al. Utilisation of an operative difficulty grading scale for laparoscopic cholecystectomy. Surg Endosc. 2019;33:110–21.PubMed Griffiths EA, Hodson J, Vohra RS, Marriott P, Katbeh T, Zino S, et al. Utilisation of an operative difficulty grading scale for laparoscopic cholecystectomy. Surg Endosc. 2019;33:110–21.PubMed
10.
go back to reference Al Masri S, Shaib Y, Edelbi M, Tamim H, Jamali F, Batley N, et al. Predicting conversion from laparoscopic to open cholecystectomy: a single institution retrospective study. World J Surg. 2018;42:2373–82.PubMed Al Masri S, Shaib Y, Edelbi M, Tamim H, Jamali F, Batley N, et al. Predicting conversion from laparoscopic to open cholecystectomy: a single institution retrospective study. World J Surg. 2018;42:2373–82.PubMed
11.
go back to reference Spohnholz J, Herzog T, Munding J, Belyaev O, Uhl W, Braumann C, et al. Conversion cholecystectomy in patients with acute cholecystitis-it’s not as black as it’s painted! Langenbecks Arch Surg. 2016;401:479–88.PubMed Spohnholz J, Herzog T, Munding J, Belyaev O, Uhl W, Braumann C, et al. Conversion cholecystectomy in patients with acute cholecystitis-it’s not as black as it’s painted! Langenbecks Arch Surg. 2016;401:479–88.PubMed
12.
go back to reference Takemoto Y, Abe T, Amano H, Hanada K, Fujikuni N, Yoshida M, et al. Propensity score-matching analysis of the efficacy of late cholecystectomy for acute cholecystitis. Am J Surg. 2017;214:262–6.PubMed Takemoto Y, Abe T, Amano H, Hanada K, Fujikuni N, Yoshida M, et al. Propensity score-matching analysis of the efficacy of late cholecystectomy for acute cholecystitis. Am J Surg. 2017;214:262–6.PubMed
13.
go back to reference Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205–13.CrossRef Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205–13.CrossRef
14.
go back to reference Strasberg SM, Bhalla S, Hammill CW. The Pucker sign: an operative and radiological indicator of impending operative difficulty due to severe chronic contractive inflammation in cholecystectomy. J Hepatobiliary Pancreat Sci. 2018;25:455–9.PubMed Strasberg SM, Bhalla S, Hammill CW. The Pucker sign: an operative and radiological indicator of impending operative difficulty due to severe chronic contractive inflammation in cholecystectomy. J Hepatobiliary Pancreat Sci. 2018;25:455–9.PubMed
15.
go back to reference Sippey M, Grzybowski M, Manwaring ML, Kasten KR, Chapman WH, Pofahl WE, et al. Acute cholecystitis: risk factors for conversion to an open procedure. J Surg Res. 2015;199:357–61.PubMed Sippey M, Grzybowski M, Manwaring ML, Kasten KR, Chapman WH, Pofahl WE, et al. Acute cholecystitis: risk factors for conversion to an open procedure. J Surg Res. 2015;199:357–61.PubMed
16.
go back to reference Lipman JM, Claridge JA, Haridas M, Martin MD, Yao DC, Grimes KL, et al. Preoperative findings predict conversion from laparoscopic to open cholecystectomy. Surger. 2007;142:556–63. Lipman JM, Claridge JA, Haridas M, Martin MD, Yao DC, Grimes KL, et al. Preoperative findings predict conversion from laparoscopic to open cholecystectomy. Surger. 2007;142:556–63.
17.
go back to reference Hu ASY, Menon R, Gunnarsson R, de Costa A. Risk factors for conversion of laparoscopic cholecystectomy to open surgery—a systematic literature review of 30 studies. Am J Surg. 2017;214:920–30.PubMed Hu ASY, Menon R, Gunnarsson R, de Costa A. Risk factors for conversion of laparoscopic cholecystectomy to open surgery—a systematic literature review of 30 studies. Am J Surg. 2017;214:920–30.PubMed
18.
go back to reference Wright PG, Stilwell K, Johnson J, Hefty MT, Chung MH. Predicting length of stay and conversion to open cholecystectomy for acute cholecystitis using the 2013 Tokyo Guidelines in a US population. J Hepatobiliary Pancreat Sci. 2015;22:795–801. Wright PG, Stilwell K, Johnson J, Hefty MT, Chung MH. Predicting length of stay and conversion to open cholecystectomy for acute cholecystitis using the 2013 Tokyo Guidelines in a US population. J Hepatobiliary Pancreat Sci. 2015;22:795–801.
19.
go back to reference Fuks D, Mouly C, Robert B, Hajji H, Yzet T, Regimbeau JM. Acute cholecystitis: preoperative CT can help the surgeon consider conversion from laparoscopic to open cholecystectomy. Radiology. 2012;263:128–38.CrossRef Fuks D, Mouly C, Robert B, Hajji H, Yzet T, Regimbeau JM. Acute cholecystitis: preoperative CT can help the surgeon consider conversion from laparoscopic to open cholecystectomy. Radiology. 2012;263:128–38.CrossRef
20.
go back to reference Goonawardena J, Gunnarsson R, de Costa A. Predicting conversion from laparoscopic to open cholecystectomy presented as a probability nomogram based on preoperative patient risk factors. Am J Surg. 2015;210:492–500.PubMed Goonawardena J, Gunnarsson R, de Costa A. Predicting conversion from laparoscopic to open cholecystectomy presented as a probability nomogram based on preoperative patient risk factors. Am J Surg. 2015;210:492–500.PubMed
21.
go back to reference Sutcliffe RP, Hollyman M, Hodson J, Bonney G, Vohra RS, Griffiths EA, et al. Preoperative risk factors for conversion from laparoscopic to open cholecystectomy: a validated risk score derived from a prospective U.K. database of 8820 patients. HPB: Off J Int Hepato Pancreato Biliary Assoc. 2016;18:922–8. Sutcliffe RP, Hollyman M, Hodson J, Bonney G, Vohra RS, Griffiths EA, et al. Preoperative risk factors for conversion from laparoscopic to open cholecystectomy: a validated risk score derived from a prospective U.K. database of 8820 patients. HPB: Off J Int Hepato Pancreato Biliary Assoc. 2016;18:922–8.
Metadata
Title
Identification of risk factors for open conversion from laparoscopic cholecystectomy for acute cholecystitis based on computed tomography findings
Authors
Ryosuke Hirohata
Tomoyuki Abe
Hironobu Amano
Keiji Hanada
Tsuyoshi Kobayashi
Hideki Ohdan
Toshio Noriyuki
Masahiro Nakahara
Publication date
01-12-2020
Publisher
Springer Singapore
Published in
Surgery Today / Issue 12/2020
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-020-02069-5

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