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01-08-2019 | Rectal Cancer | Original Article

Feasibility of neoadjuvant therapy for elderly patients with locally advanced rectal cancer

Authors: Tetsuro Tominaga, Toshiya Nagasaki, Takashi Akiyoshi, Yosuke Fukunaga, Yoshiya Fujimoto, Tomohiro Yamaguchi, Tsuyoshi Konishi, Satoshi Nagayama, Masashi Ueno

Published in: Surgery Today | Issue 8/2019

Abstract

Purpose

The feasibility of neoadjuvant therapy (NAT) for elderly patients with rectal cancer has not been evaluated well.

Methods

Between 2004 and 2014, 506 patients with locally advanced low rectal cancer underwent curative resection. Fifty-four were over 75 years old (elderly group), and 452 were under 75 years old (young group). The patients were divided into sub-groups according to whether they received NAT.

Results

Nineteen (35.2%) patients from the elderly group and 348 (77.0%) from the young group received NAT. The proportion of patients who received NAT was significantly lower in the elderly group. In the elderly group, the median age and prevalence of co-morbidities were significantly lower in patients with than in those without NAT. The incidence of severe adverse events was similar in the two groups. On multivariate analysis, age was not related to postoperative complications in patients who received NAT. The 5-year local recurrence rate was significantly lower in the elderly patients who received NAT, and similar to that of the young patients who received NAT.

Conclusions

Neoadjuvant therapy was feasible and should be considered as a treatment option for carefully selected elderly patients with locally advanced low rectal cancer.

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Title: Feasibility of neoadjuvant therapy for elderly patients with locally advanced rectal cancer
Authors: Tetsuro Tominaga
Toshiya Nagasaki
Takashi Akiyoshi
Yosuke Fukunaga
Yoshiya Fujimoto
Tomohiro Yamaguchi
Tsuyoshi Konishi
Satoshi Nagayama
Masashi Ueno
Publication date: 01-08-2019
Publisher: Springer Singapore
Keywords: Rectal Cancer
Rectal Cancer
Published in: Surgery Today / Issue 8/2019
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-019-01801-0

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Feasibility of neoadjuvant therapy for elderly patients with locally advanced rectal cancer

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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