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01-07-2019 | Metastasis | Original Article

Predictive value of the Ki67 index for lymph node metastasis of small non-functioning pancreatic neuroendocrine neoplasms

Authors: Toshihiko Masui, Asahi Sato, Kenzo Nakano, Yuichiro Uchida, Akitada Yogo, Takayuki Anazawa, Kazuyuki Nagai, Yoshiya Kawaguchi, Kyoichi Takaori, Shinji Uemoto

Published in: Surgery Today | Issue 7/2019

Abstract

Background

We evaluated the clinicopathological factors associated with lymph node metastasis in patients with non-functioning pancreatic neuroendocrine neoplasms (PanNENs), focusing on the risk factors and range of lymph node metastasis for tumors ≤ 2 cm in diameter.

Methods

The subjects of this study were patients with PanNENs consecutively diagnosed at our hospital between January, 2000 and June, 2018. We analyzed 69 patients who underwent R0 resection of a non-functioning sporadic PanNEN with no distant metastasis, as well as 43 patients with tumors ≤ 20 mm in radiological diameter.

Results

Nineteen patients (27.5%), including 7 (16.3%) with a small PanNEN, had lymph node metastasis. A large radiological diameter, a high Ki67 index, and cyst formation correlated significantly with positive lymph node metastasis. In patients with tumors ≤ 20 mm in diameter, a high Ki67 index correlated significantly with lymph node metastasis. When we set the cut-off Ki67 index as 3.3%, 2 of 43 patients had lymph node metastasis. Tumors in the uncinate process readily metastasized to the region around the superior mesenteric artery.

Conclusions

These findings suggest that a high Ki67 index indicates a risk of lymph node metastasis for tumors ≤ 20 mm in diameter and that lymphadenectomy should be performed in the region spatially adjacent to the primary tumor.

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Title: Predictive value of the Ki67 index for lymph node metastasis of small non-functioning pancreatic neuroendocrine neoplasms
Authors: Toshihiko Masui
Asahi Sato
Kenzo Nakano
Yuichiro Uchida
Akitada Yogo
Takayuki Anazawa
Kazuyuki Nagai
Yoshiya Kawaguchi
Kyoichi Takaori
Shinji Uemoto
Publication date: 01-07-2019
Publisher: Springer Singapore
Keyword: Metastasis
Published in: Surgery Today / Issue 7/2019
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-019-01779-9

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Predictive value of the Ki67 index for lymph node metastasis of small non-functioning pancreatic neuroendocrine neoplasms

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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