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Surgery Today
Published in: Surgery Today 2/2019

01-02-2019 | Original Article

Adverse oncological outcome of surgical site infection after liver resection for colorectal liver metastases

Authors: Yasuyuki Fukami, Atsuyuki Maeda, Yuichi Takayama, Takamasa Takahashi, Masahito Uji, Yuji Kaneoka

Published in: Surgery Today | Issue 2/2019

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Abstract

Purposes

Postoperative complications are associated with poor overall and cancer-specific survival after resection of various types of cancer, including primary colorectal cancer. However, the oncological impact of surgical site infection (SSI) after liver resection for colorectal liver metastases (CLM) is unclear. The aim of this study was to investigate the oncological impact of SSI after liver resection for CLM.

Methods

We reviewed data from 367 consecutive patients treated by curative liver resection for CLM between 1994 and 2015. Patients who underwent simultaneous resection of colorectal cancer and synchronous liver metastases (n = 86) were excluded from the analysis. Short- and long-term outcomes were analyzed.

Results

SSI developed in 18 (6.4%) of the 281 patients in the analytic cohort (SSI group). The remaining 93.6% (n = 263) did not suffer this complication (no-SSI group). The operative duration was significantly longer in the SSI group than in the No-SSI group (p = 0.002). The overall survival rates 5 years after liver resection for CLM were 33.3% in the SSI group vs. 50.7% in the No-SSI group (p = 0.043). Multivariate analysis indicated that a liver tumor size ≥ 5 cm, R1 resection, and SSI were independently associated with overall survival after liver resection.

Conclusions

SSI after liver resection for CLM is associated with adverse oncological outcomes.
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Metadata
Title
Adverse oncological outcome of surgical site infection after liver resection for colorectal liver metastases
Authors
Yasuyuki Fukami
Atsuyuki Maeda
Yuichi Takayama
Takamasa Takahashi
Masahito Uji
Yuji Kaneoka
Publication date
01-02-2019
Publisher
Springer Singapore
Published in
Surgery Today / Issue 2/2019
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-018-1715-y

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