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Surgery Today
Published in: Surgery Today 5/2018

01-05-2018 | Original Article

Correlation between the skeletal muscle index and surgical outcomes of pancreaticoduodenectomy

Authors: Kenta Sui, Takehiro Okabayshi, Jun Iwata, Sojiro Morita, Tatsuaki Sumiyoshi, Tatsuo Iiyama, Yasuhiro Shimada

Published in: Surgery Today | Issue 5/2018

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Abstract

Purposes

Sarcopenia is known to be associated with a worse prognosis following abdominal operations; however, the relationship between sarcopenia and the outcomes of pancreaticoduodenectomy remains unclear.

Materials

We measured body composition parameters, including total abdominal muscle area, using preoperative staging computed tomography (CT), in patients undergoing pancreaticoduodenectomy for periampullary cancer. The incidence of sarcopenia among these patients was evaluated and multivariable analysis was performed to identify independent predictors of postoperative pancreatic fistula.

Results

We identified 335 consecutive patients who were eligible for the study. Patients with sarcopenia had significantly poorer 5-year survival rates than those without sarcopenia (32.4 vs. 51.6%, respectively, P = 0.009). Interestingly, the incidence of Grade B/C pancreatic fistula was significantly lower in the sarcopenia group than in the non-sarcopenia group. Multivariate analysis identified high body mass index and soft pancreatic texture as independent predictors of postoperative pancreatic fistula.

Conclusion

Sarcopenia may have an independent prognostic effect on the survival of patients with periampullary cancer. Preoperative nutritional intervention and rehabilitation may improve the postoperative outcomes of pancreaticoduodenectomy for periampullary cancer.
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Metadata
Title
Correlation between the skeletal muscle index and surgical outcomes of pancreaticoduodenectomy
Authors
Kenta Sui
Takehiro Okabayshi
Jun Iwata
Sojiro Morita
Tatsuaki Sumiyoshi
Tatsuo Iiyama
Yasuhiro Shimada
Publication date
01-05-2018
Publisher
Springer Singapore
Published in
Surgery Today / Issue 5/2018
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-017-1622-7

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