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Surgery Today
Published in: Surgery Today 1/2018

01-01-2018 | Review Article

Treatment of lung adenocarcinoma by molecular-targeted therapy and immunotherapy

Authors: Motonobu Saito, Hiroyuki Suzuki, Koji Kono, Seiichi Takenoshita, Takashi Kohno

Published in: Surgery Today | Issue 1/2018

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Abstract

Lung adenocarcinoma (LADC) is a cancer treatable using targeted therapies against driver gene aberrations. EGFR mutations and ALK fusions are frequent gene aberrations in LADC, and personalized therapies against those aberrations have become a standard therapy. These targeted therapies have shown significant positive efficacy and tolerable toxicity compared to conventional chemotherapy, so it is necessary to identify additional druggable genetic aberrations. Other than EGFR mutations and ALK fusions, mutations in KRAS, HER2, and BRAF, and driver fusions involving RET and ROS1, have also been identified in LADC. Interestingly, the frequency of driver gene aberrations differs according to ethnicity, sex, and smoking, which leads to differences in treatment efficacy. To date, several molecular-targeted drugs against driver genes have been developed, and several clinical trials have been conducted to evaluate the efficacy. However, targeted therapies against driver-gene-negative cases have not yet been well developed. Efforts to identify a new druggable target for such cases are currently underway. Furthermore, immune checkpoint blockade therapy might be effective for driver-negative cases, especially those with accumulated mutations.
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Metadata
Title
Treatment of lung adenocarcinoma by molecular-targeted therapy and immunotherapy
Authors
Motonobu Saito
Hiroyuki Suzuki
Koji Kono
Seiichi Takenoshita
Takashi Kohno
Publication date
01-01-2018
Publisher
Springer Japan
Published in
Surgery Today / Issue 1/2018
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-017-1497-7

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