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Published in: Surgery Today 7/2017

01-07-2017 | Original Article

Outcome and risk factors of recurrence after thoracoscopic bullectomy in young adults with primary spontaneous pneumothorax

Authors: Takashi Nakayama, Yusuke Takahashi, Hirofumi Uehara, Noriyuki Matsutani, Masafumi Kawamura

Published in: Surgery Today | Issue 7/2017

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Abstract

Purpose

To investigate the risk factors of recurrence of pneumothorax following thoracoscopic bullectomy in young adults.

Methods

Between January, 2005 and September, 2015, 167 patients aged ≤40 years underwent initial thoracoscopic bullectomy for primary spontaneous pneumothorax (PSP) at our hospital. Recurrence-free probability was calculated from the date of surgery to recurrence or last follow-up, using the Kaplan–Meier method.

Results

Sixteen (9.6%) of the 167 patients suffered a recurrence (collective total, 16 recurrences). The recurrence-free intervals were 3–107 months (median 25.8 months), and the 5-year recurrence-free probability was 85.9%. Multivariate Cox analysis demonstrated that age ≤23 years (p = 0.029) and a history of ipsilateral pneumothorax before surgery (p = 0.029) were significantly associated with higher risk of recurrence. The 5-year recurrence-free probability was 72.3% for patients aged ≤23 years and a history of ipsilateral pneumothorax before surgery and 94.1% for those with neither of these factors (p = 0.001). Recurrence developed within 3 years after surgery in 14 of the 16 patients.

Conclusions

Patients ≤23 years of age with a history of ipsilateral pneumothorax before surgery are at significantly high risk of its recurrence, frequently within 3 years; thus, the risk of postoperative recurrence of a pneumothorax must be kept in mind.
Literature
1.
go back to reference Sahn SA, Heffner JE. Spontaneous pneumothorax. N Engl J Med. 2000;23(342):868–74.CrossRef Sahn SA, Heffner JE. Spontaneous pneumothorax. N Engl J Med. 2000;23(342):868–74.CrossRef
2.
go back to reference Zarogoulidis P, Kioumis I, Pitsiou G, Porpodis K, Lampaki S, Papaiwannou A, et al. Pneumothorax: from definition to diagnosis and treatment. J Thorac Dis. 2014;6(Suppl 4):S372–6.PubMedPubMedCentral Zarogoulidis P, Kioumis I, Pitsiou G, Porpodis K, Lampaki S, Papaiwannou A, et al. Pneumothorax: from definition to diagnosis and treatment. J Thorac Dis. 2014;6(Suppl 4):S372–6.PubMedPubMedCentral
4.
go back to reference Santillan-Doherty P, Argote-Greene LM, Guzman-Sanchez M. Thoracoscopic management of primary spontaneous pneumothorax. Am Surg. 2006;72:145–9.PubMed Santillan-Doherty P, Argote-Greene LM, Guzman-Sanchez M. Thoracoscopic management of primary spontaneous pneumothorax. Am Surg. 2006;72:145–9.PubMed
5.
go back to reference Barker A, Maratos EC, Edmonds L, Lim E. Recurrence rates of video-assisted thoracoscopic versus open surgery in the prevention of recurrent pneumothoraces: a systematic review of randomized and non-randomised trials. Lancet. 2007;370:329–35.CrossRefPubMed Barker A, Maratos EC, Edmonds L, Lim E. Recurrence rates of video-assisted thoracoscopic versus open surgery in the prevention of recurrent pneumothoraces: a systematic review of randomized and non-randomised trials. Lancet. 2007;370:329–35.CrossRefPubMed
6.
go back to reference Muramatsu T, Nishii T, Takeshita S, Ishimoto S, Morooka H, Shiono M. Preventing recurrence of spontaneous pneumothorax after thoracoscopic surgery: a review of recent results. Surg Today. 2010;40:696–9.CrossRefPubMed Muramatsu T, Nishii T, Takeshita S, Ishimoto S, Morooka H, Shiono M. Preventing recurrence of spontaneous pneumothorax after thoracoscopic surgery: a review of recent results. Surg Today. 2010;40:696–9.CrossRefPubMed
7.
go back to reference Sakamoto K, Takei H, Nishii T, Maehara T, Omori T, Tajiri M, et al. Staple line coverage with absorbable mesh after thoracoscopic bullectomy for spontaneous pneumothorax. Surg Endosc. 2004;18:478–81.CrossRefPubMed Sakamoto K, Takei H, Nishii T, Maehara T, Omori T, Tajiri M, et al. Staple line coverage with absorbable mesh after thoracoscopic bullectomy for spontaneous pneumothorax. Surg Endosc. 2004;18:478–81.CrossRefPubMed
8.
go back to reference Lee S, Kim HR, Cho S, Huh DM, Lee EB, Ryu KM, et al. Staple line coverage after bullectomy for primary spontaneous pneumothorax: a randomized trial. Ann Thorac Surg. 2014;98:2005–11.CrossRefPubMed Lee S, Kim HR, Cho S, Huh DM, Lee EB, Ryu KM, et al. Staple line coverage after bullectomy for primary spontaneous pneumothorax: a randomized trial. Ann Thorac Surg. 2014;98:2005–11.CrossRefPubMed
9.
go back to reference Casadio C, Rena O, Giobbe R, Rigoni R, Maggi G, Oliaro A. Stapler blebectomy and pleural abrasion by video-assisted thoracoscopy for spontaneous pneumothorax. J Cardiovasc Surg. 2002;43:259–62. Casadio C, Rena O, Giobbe R, Rigoni R, Maggi G, Oliaro A. Stapler blebectomy and pleural abrasion by video-assisted thoracoscopy for spontaneous pneumothorax. J Cardiovasc Surg. 2002;43:259–62.
10.
go back to reference Herrmann D, Klapdor B, Ewig S, Hecker E. Initial management of primary spontaneous pneumothorax with video-assisted thoracoscopic surgery: a 10-year experience. Eur J Cardiothorac Surg. 2015;. doi:10.1093/ejcts/ezv206.PubMed Herrmann D, Klapdor B, Ewig S, Hecker E. Initial management of primary spontaneous pneumothorax with video-assisted thoracoscopic surgery: a 10-year experience. Eur J Cardiothorac Surg. 2015;. doi:10.​1093/​ejcts/​ezv206.PubMed
11.
go back to reference Cutler SJ, Ederer F. Maximum utilization of the life table method in analyzing survival. J Chronic Dis. 1958;8:699–712.CrossRefPubMed Cutler SJ, Ederer F. Maximum utilization of the life table method in analyzing survival. J Chronic Dis. 1958;8:699–712.CrossRefPubMed
12.
go back to reference Kennecke HF, Olivotto IA, Speers C, Norris B, Chia SK, Bryce C, et al. Late risk of relapse and mortality among postmenopausal women with estrogen responsive early breast cancer after 5 years of tamoxifen. Ann Oncol. 2007;18:45–51.CrossRefPubMed Kennecke HF, Olivotto IA, Speers C, Norris B, Chia SK, Bryce C, et al. Late risk of relapse and mortality among postmenopausal women with estrogen responsive early breast cancer after 5 years of tamoxifen. Ann Oncol. 2007;18:45–51.CrossRefPubMed
13.
go back to reference Maeda R, Yoshida J, Ishii G, Aokage K, Hishida T, Nishimura M, et al. Long-term outcome and late recurrence in patients with completely resected stage IA non-small cell lung cancer. J Thorac Oncol. 2010;5:1246–50.CrossRefPubMed Maeda R, Yoshida J, Ishii G, Aokage K, Hishida T, Nishimura M, et al. Long-term outcome and late recurrence in patients with completely resected stage IA non-small cell lung cancer. J Thorac Oncol. 2010;5:1246–50.CrossRefPubMed
14.
go back to reference Schramel FM, Postmus PE, Vanderschueren RG. Current aspects of spontaneous pneumothorax. Eur Respir J. 1997;10:1372–9.CrossRefPubMed Schramel FM, Postmus PE, Vanderschueren RG. Current aspects of spontaneous pneumothorax. Eur Respir J. 1997;10:1372–9.CrossRefPubMed
15.
go back to reference Choi SY, Kim YH, Jo KH, Kim CK, Park JK, Cho DG, et al. Video-assisted thoracoscopic surgery for primary spontaneous pneumothorax in children. Pediatr Surg Int. 2013;29:505–9.CrossRefPubMed Choi SY, Kim YH, Jo KH, Kim CK, Park JK, Cho DG, et al. Video-assisted thoracoscopic surgery for primary spontaneous pneumothorax in children. Pediatr Surg Int. 2013;29:505–9.CrossRefPubMed
16.
go back to reference West JB. Distribution of mechanical stress in the lung, a possible factor in localisation of pulmonary disease. Lancet. 1971;24(1):839–41.CrossRef West JB. Distribution of mechanical stress in the lung, a possible factor in localisation of pulmonary disease. Lancet. 1971;24(1):839–41.CrossRef
17.
go back to reference Moriyama S, Okutani D. Analysis of risk factors of recurrence of primary spontaneous pneumothorax (in Japanese with English abstract). Nihon Kikyo Nouhousei Haisikkann Gakkaizasshi (J Jpn Soc Pneumothorax Cystic Lung Dis). 2010; 10:96–100. Moriyama S, Okutani D. Analysis of risk factors of recurrence of primary spontaneous pneumothorax (in Japanese with English abstract). Nihon Kikyo Nouhousei Haisikkann Gakkaizasshi (J Jpn Soc Pneumothorax Cystic Lung Dis). 2010; 10:96–100.
18.
go back to reference Tschopp JM, Bintcliffe O, Astoul P, Canalis E, Driesen P, Janssen J, et al. ERS task force statement: diagnosis and treatment of primary spontaneous pneumothorax. Eur Respir J. 2015;46:321–35.CrossRefPubMed Tschopp JM, Bintcliffe O, Astoul P, Canalis E, Driesen P, Janssen J, et al. ERS task force statement: diagnosis and treatment of primary spontaneous pneumothorax. Eur Respir J. 2015;46:321–35.CrossRefPubMed
19.
go back to reference Huang TW, Lee SC, Cheng YL, Tzao C, Hsu HH, Chang H, et al. Contralateral recurrence of primary spontaneous pneumothorax. Chest. 2007;132:1146–50.CrossRefPubMed Huang TW, Lee SC, Cheng YL, Tzao C, Hsu HH, Chang H, et al. Contralateral recurrence of primary spontaneous pneumothorax. Chest. 2007;132:1146–50.CrossRefPubMed
20.
go back to reference Imperatori A, Rotolo N, Spagnoletti M, Festi L, Berizzi F, Di Natale D, et al. Risk factors for postoperative recurrence of spontaneous pneumothorax treated by video-assisted thoracoscopic surgerydagger. Interact CardioVasc Thorac Surg. 2015;20:647–52.CrossRefPubMed Imperatori A, Rotolo N, Spagnoletti M, Festi L, Berizzi F, Di Natale D, et al. Risk factors for postoperative recurrence of spontaneous pneumothorax treated by video-assisted thoracoscopic surgerydagger. Interact CardioVasc Thorac Surg. 2015;20:647–52.CrossRefPubMed
21.
go back to reference Min X, Huang Y, Yang Y, Chen Y, Cui J, Wang C, et al. Mechanical pleurodesis does not reduce recurrence of spontaneous pneumothorax: a randomized trial. Ann Thorac Surg. 2014;98:1790–6.CrossRefPubMed Min X, Huang Y, Yang Y, Chen Y, Cui J, Wang C, et al. Mechanical pleurodesis does not reduce recurrence of spontaneous pneumothorax: a randomized trial. Ann Thorac Surg. 2014;98:1790–6.CrossRefPubMed
Metadata
Title
Outcome and risk factors of recurrence after thoracoscopic bullectomy in young adults with primary spontaneous pneumothorax
Authors
Takashi Nakayama
Yusuke Takahashi
Hirofumi Uehara
Noriyuki Matsutani
Masafumi Kawamura
Publication date
01-07-2017
Publisher
Springer Japan
Published in
Surgery Today / Issue 7/2017
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-016-1452-z

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