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Published in: Surgery Today 6/2017

01-06-2017 | Original Article

Immune function monitoring in lung transplantation using adenosine triphosphate production: time trends and relationship to postoperative infection

Authors: Mamoru Takahashi, Akihiro Ohsumi, Keiji Ohata, Takeshi Kondo, Hideki Motoyama, Kyoko Hijiya, Akihiro Aoyama, Hiroshi Date, Toyofumi F. Chen-Yoshikawa

Published in: Surgery Today | Issue 6/2017

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Abstract

Purpose

The ImmuKnow (IK) assay is a comprehensive immune function test that involves measuring adenosine triphosphate produced by the cluster of differentiation 4+ T lymphocytes in peripheral blood. The aim of this study was to analyze the time trends of IK values and assess the relationship between IK values and infections in lung transplants.

Methods

We prospectively collected 178 blood samples from 22 deceased-donor lung transplant (DDLT) recipients and 17 living-donor lobar lung transplant (LDLLT) recipients. A surveillance IK assay was performed postoperatively, then after 1 week and 1, 3, 6, and 12 months.

Results

Time trends of IK values in stable recipients peaked 1 week after DDLT (477 ± 247 ATP ng/ml), and 1 month after LDLLT (433 ± 134 ng/ml), followed by a gradual decline over 1 year. The mean IK values in infections were significantly lower than those in the stable state (119 vs 312 ATP ng/ml, p = 0.0002).

Conclusions

IK values increased sharply after lung transplantation and then decreased gradually over time in the first year, suggesting a natural history of immune function. IK values were also significantly reduced during infections. These results may provide new insights into the utility of immune monitoring after lung transplantation.
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Metadata
Title
Immune function monitoring in lung transplantation using adenosine triphosphate production: time trends and relationship to postoperative infection
Authors
Mamoru Takahashi
Akihiro Ohsumi
Keiji Ohata
Takeshi Kondo
Hideki Motoyama
Kyoko Hijiya
Akihiro Aoyama
Hiroshi Date
Toyofumi F. Chen-Yoshikawa
Publication date
01-06-2017
Publisher
Springer Japan
Published in
Surgery Today / Issue 6/2017
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-016-1440-3

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