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Surgery Today
Published in: Surgery Today 1/2017

01-01-2017 | Short Communication

Duodenal-jejunal bypass changes the composition of the gut microbiota

Authors: Hideya Kashihara, Mitsuo Shimada, Kozo Yoshikawa, Jun Higashijima, Toshihiro Nakao, Masaaki Nishi, Chie Takasu

Published in: Surgery Today | Issue 1/2017

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Abstract

This study investigated the composition of the gut microbiota in rats after duodenal-jejunal bypass (DJB) in comparison to that in rats injected with a glucagon-like peptide-1 (GLP-1) receptor analog. Six male 16-week-old OLETF rats were divided into three groups: a DJB group, a sham operation group, and a daily injection with a GLP-1 receptor agonist (liraglutide) group. The gut microbiota of the three groups was analyzed at postoperative week 8 using the PCR-clone library method targeting the 16S ribosomal RNA gene. The DJB group showed a decrease in Bacteroidia in comparison to the other two groups (DJB, 3.9 %/2.8 %; sham, 10.8 %/11.6 %; liraglutide, 33.2 %/14.1 %). In addition, DJB markedly increased the ratio of Gammaproteobacteria (DJB, 10.8 %/13.7 %; sham, 0.2 %/1.2 %; liraglutide, 0 %/0.1 %). DJB changes the composition of gut microbiota; these changes might be the factors that contribute to the effects of DJB.
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Metadata
Title
Duodenal-jejunal bypass changes the composition of the gut microbiota
Authors
Hideya Kashihara
Mitsuo Shimada
Kozo Yoshikawa
Jun Higashijima
Toshihiro Nakao
Masaaki Nishi
Chie Takasu
Publication date
01-01-2017
Publisher
Springer Japan
Published in
Surgery Today / Issue 1/2017
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-016-1373-x

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