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Published in: Surgery Today 1/2016

01-01-2016 | Original Article

Novel management of postoperative pain using only oral analgesics after LADG

Authors: Jota Mikami, Shuji Takiguchi, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Makoto Yamasaki, Hiroshi Miyata, Kiyokazu Nakajima, Masaki Mori, Yuichiro Doki

Published in: Surgery Today | Issue 1/2016

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Abstract

Purpose

Managing postoperative pain is important to ensure a good quality of life and fast recovery after surgery. We examined the feasibility of peroral management for the postoperative pain after laparoscopic-assisted distal gastrectomy (LADG).

Methods

Between June 2012 and September 2013, we enrolled 34 patients prospectively to receive peroral tramadol/acetaminophen combination tablets, celecoxib and prochlorperazine maleate after LADG through postoperative day 3 (ORAL group). The postoperative pain was assessed using a visual analogue scale. Postoperative outcomes related to the analgesic methods were compared with those of patients who used epidural anesthesia between January 2010 and December 2011 (EPI group).

Results

The ORAL group pain scale scores on postoperative days 1–3 were 3.96, 3.06 and 2.40, respectively. The frequency of additional analgesic use in the ORAL group was significantly lower than in the EPI group (P = 0.006). The rate of urethral catheter reinsertion was 20.6 % in the EPI group (P = 0.054). A multivariate analysis revealed that only epidural anesthesia was a significant risk factor for the need for additional medication four times or more for breakthrough pain (P = 0.048).

Conclusion

Postoperative pain management using oral analgesics after LADG is feasible and safe, and is an ideal pain treatment associated with few adverse events while providing pain relief not inferior to epidural anesthesia.
Literature
1.
go back to reference Kitano S, Iso Y, Moriyama M, Sugimachi K. Laparoscopy-assisted Billroth I gastrectomy. Surg Laparosc Endosc. 1994;4:146–8.PubMed Kitano S, Iso Y, Moriyama M, Sugimachi K. Laparoscopy-assisted Billroth I gastrectomy. Surg Laparosc Endosc. 1994;4:146–8.PubMed
2.
go back to reference Takayama T, Matsumoto S, Wakatsuki K, Tanaka T, Migita K, Ito M et al. A novel laparoscopic procedure for treating proximal early gastric cancer: laparoscopy-assisted pylorus-preserving nearly total gastrectomy. Surg Today 2014 (in press). Takayama T, Matsumoto S, Wakatsuki K, Tanaka T, Migita K, Ito M et al. A novel laparoscopic procedure for treating proximal early gastric cancer: laparoscopy-assisted pylorus-preserving nearly total gastrectomy. Surg Today 2014 (in press).
3.
go back to reference Yamashita K, Sakuramoto S, Shibata T, Nemoto M, Mieno H, Katada N, et al. Survival outcome of laparoscopic gastrectomy for clinical early (cT1) gastric cancer. Surg Today. 2013;43:1013–8.CrossRefPubMed Yamashita K, Sakuramoto S, Shibata T, Nemoto M, Mieno H, Katada N, et al. Survival outcome of laparoscopic gastrectomy for clinical early (cT1) gastric cancer. Surg Today. 2013;43:1013–8.CrossRefPubMed
4.
go back to reference Vlug MS, Wind J, van der Zaag E, Ubbink DT, Cense HA, Bemelman WA. Systematic review of laparoscopic vs open colonic surgery within an enhanced recovery programme. Colorectal Dis. 2009;11:335–43.CrossRefPubMed Vlug MS, Wind J, van der Zaag E, Ubbink DT, Cense HA, Bemelman WA. Systematic review of laparoscopic vs open colonic surgery within an enhanced recovery programme. Colorectal Dis. 2009;11:335–43.CrossRefPubMed
5.
go back to reference Tomikawa M, Korenaga D, Akahoshi T, Kohshi K, Sugimachi K, Nagao Y, et al. Quality of life after laparoscopy-assisted pylorus-preserving gastrectomy: an evaluation using a questionnaire mailed to the patients. Surg Today. 2012;42:625–32.CrossRefPubMed Tomikawa M, Korenaga D, Akahoshi T, Kohshi K, Sugimachi K, Nagao Y, et al. Quality of life after laparoscopy-assisted pylorus-preserving gastrectomy: an evaluation using a questionnaire mailed to the patients. Surg Today. 2012;42:625–32.CrossRefPubMed
6.
go back to reference Ishikawa K, Matsumata T, Kishihara F, Fukuyama Y, Masuda H. Laparoscopy-assisted distal gastrectomy for early gastric cancer with versus without prophylactic drainage. Surg Today. 2011;41:1049–53.CrossRefPubMed Ishikawa K, Matsumata T, Kishihara F, Fukuyama Y, Masuda H. Laparoscopy-assisted distal gastrectomy for early gastric cancer with versus without prophylactic drainage. Surg Today. 2011;41:1049–53.CrossRefPubMed
7.
go back to reference Smith AB, Ravikumar TS, Kamin M, Jordan D, Xiang J, Rosenthal N. Combination tramadol plus acetaminophen for postsurgical pain. Am J Surg. 2004;187:521–7.CrossRefPubMed Smith AB, Ravikumar TS, Kamin M, Jordan D, Xiang J, Rosenthal N. Combination tramadol plus acetaminophen for postsurgical pain. Am J Surg. 2004;187:521–7.CrossRefPubMed
8.
go back to reference Rigg JRA, Jamrozik K, Myles PS, Silbert BS, Peyton PJ, Parsons RW, et al. Epidural anaesthesia and analgesia and outcome of major surgery: a randomised trial. Lancet. 2002;359:1276–82.CrossRefPubMed Rigg JRA, Jamrozik K, Myles PS, Silbert BS, Peyton PJ, Parsons RW, et al. Epidural anaesthesia and analgesia and outcome of major surgery: a randomised trial. Lancet. 2002;359:1276–82.CrossRefPubMed
9.
go back to reference Belavy D, Janda M, Baker J, Obermair A. Epidural analgesia is associated with an increased incidence of postoperative complications in patients requiring an abdominal hysterectomy for early stage endometrial cancer. Gynecol Oncol. 2013;131:423–9.CrossRefPubMed Belavy D, Janda M, Baker J, Obermair A. Epidural analgesia is associated with an increased incidence of postoperative complications in patients requiring an abdominal hysterectomy for early stage endometrial cancer. Gynecol Oncol. 2013;131:423–9.CrossRefPubMed
10.
go back to reference Joshi GP, Bonnet F, Kehlet H. Evidence-based postoperative pain management after laparoscopic colorectal surgery. Colorectal Dis. 2013;15:146–55.CrossRefPubMed Joshi GP, Bonnet F, Kehlet H. Evidence-based postoperative pain management after laparoscopic colorectal surgery. Colorectal Dis. 2013;15:146–55.CrossRefPubMed
11.
go back to reference Matsutani N, Kawamura M. Successful management of postoperative pain with pregabalin after thoracotomy. Surg Today. 2014;44:712–5.CrossRefPubMed Matsutani N, Kawamura M. Successful management of postoperative pain with pregabalin after thoracotomy. Surg Today. 2014;44:712–5.CrossRefPubMed
12.
go back to reference Kehlet H, Gray AW, Bonnet F, Camu F, Fischer HB, McCloy RF, et al. A procedure-specific systematic review and consensus recommendations for postoperative analgesia following laparoscopic cholecystectomy. Surg Endosc. 2005;19:1396–415.CrossRefPubMed Kehlet H, Gray AW, Bonnet F, Camu F, Fischer HB, McCloy RF, et al. A procedure-specific systematic review and consensus recommendations for postoperative analgesia following laparoscopic cholecystectomy. Surg Endosc. 2005;19:1396–415.CrossRefPubMed
13.
go back to reference Kogan A, Medalion B, Raanani E, Sharoni E, Stamler A, Pak N, et al. Early oral analgesia after fast-track cardiac anesthesia. Can J Anaesth. 2007;54:254–61.CrossRefPubMed Kogan A, Medalion B, Raanani E, Sharoni E, Stamler A, Pak N, et al. Early oral analgesia after fast-track cardiac anesthesia. Can J Anaesth. 2007;54:254–61.CrossRefPubMed
14.
go back to reference Vickers MD, Paravicini D. Comparison of tramadol with morphine for post-operative pain following abdominal surgery. Eur J Anaesthesiol. 1995;12:265–71.PubMed Vickers MD, Paravicini D. Comparison of tramadol with morphine for post-operative pain following abdominal surgery. Eur J Anaesthesiol. 1995;12:265–71.PubMed
15.
go back to reference Alanoglu Z, Ates Y, Orbey BC, Turkcapar AG. Preoperative use of selective COX-II inhibitors for pain management in laparoscopic nissen fundoplication. Surg Endosc. 2005;19:1182–7.CrossRefPubMed Alanoglu Z, Ates Y, Orbey BC, Turkcapar AG. Preoperative use of selective COX-II inhibitors for pain management in laparoscopic nissen fundoplication. Surg Endosc. 2005;19:1182–7.CrossRefPubMed
16.
go back to reference Joshi GP, Viscusi ER, Gan TJ, Minkowitz H, Cippolle M, Schuller R, et al. Effective treatment of laparoscopic cholecystectomy pain with intravenous followed by oral COX-2 specific inhibitor. Anesth Analg. 2004;98:336–42 (table of contents).CrossRefPubMed Joshi GP, Viscusi ER, Gan TJ, Minkowitz H, Cippolle M, Schuller R, et al. Effective treatment of laparoscopic cholecystectomy pain with intravenous followed by oral COX-2 specific inhibitor. Anesth Analg. 2004;98:336–42 (table of contents).CrossRefPubMed
17.
go back to reference Association Japanese Gastric Cancer. Japanese gastric cancer treatment guidelines 2010 (ver. 3). Gastric Cancer. 2011;14:113–23.CrossRef Association Japanese Gastric Cancer. Japanese gastric cancer treatment guidelines 2010 (ver. 3). Gastric Cancer. 2011;14:113–23.CrossRef
18.
go back to reference Association Japanese Gastric Cancer. Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer. 2011;14:101–12.CrossRef Association Japanese Gastric Cancer. Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer. 2011;14:101–12.CrossRef
19.
go back to reference Silverfield JC, Kamin M, Wu SC, Rosenthal N. Tramadol/acetaminophen combination tablets for the treatment of osteoarthritis flare pain: a multicenter, outpatient, randomized, double-blind, placebo-controlled, parallel-group, add-on study. Clin Ther. 2002;24:282–97.CrossRefPubMed Silverfield JC, Kamin M, Wu SC, Rosenthal N. Tramadol/acetaminophen combination tablets for the treatment of osteoarthritis flare pain: a multicenter, outpatient, randomized, double-blind, placebo-controlled, parallel-group, add-on study. Clin Ther. 2002;24:282–97.CrossRefPubMed
20.
go back to reference Fricke JR Jr, Karim R, Jordan D, Rosenthal N. A double-blind, single-dose comparison of the analgesic efficacy of tramadol/acetaminophen combination tablets, hydrocodone/acetaminophen combination tablets, and placebo after oral surgery. Clin Ther. 2002;24:953–68.CrossRefPubMed Fricke JR Jr, Karim R, Jordan D, Rosenthal N. A double-blind, single-dose comparison of the analgesic efficacy of tramadol/acetaminophen combination tablets, hydrocodone/acetaminophen combination tablets, and placebo after oral surgery. Clin Ther. 2002;24:953–68.CrossRefPubMed
21.
22.
go back to reference Imasogie NN, Singh S, Watson JT, Hurley D, Morley-Forster P. Ultra low-dose naloxone and tramadol/acetaminophen in elderly patients undergoing joint replacement surgery: a pilot study. Pain Res Manag. 2009;14:103–8.PubMedCentralPubMed Imasogie NN, Singh S, Watson JT, Hurley D, Morley-Forster P. Ultra low-dose naloxone and tramadol/acetaminophen in elderly patients undergoing joint replacement surgery: a pilot study. Pain Res Manag. 2009;14:103–8.PubMedCentralPubMed
23.
go back to reference Pergolizzi JV Jr, van de Laar M, Langford R, Mellinghoff HU, Merchante IM, Nalamachu S, et al. Tramadol/paracetamol fixed-dose combination in the treatment of moderate to severe pain. J Pain Res. 2012;5:327–46.PubMedCentralCrossRefPubMed Pergolizzi JV Jr, van de Laar M, Langford R, Mellinghoff HU, Merchante IM, Nalamachu S, et al. Tramadol/paracetamol fixed-dose combination in the treatment of moderate to severe pain. J Pain Res. 2012;5:327–46.PubMedCentralCrossRefPubMed
24.
go back to reference Edwards JE, McQuay HJ, Moore RA. Combination analgesic efficacy: individual patient data meta-analysis of single-dose oral tramadol plus acetaminophen in acute postoperative pain. J Pain Symptom Manage. 2002;23:121–30.CrossRefPubMed Edwards JE, McQuay HJ, Moore RA. Combination analgesic efficacy: individual patient data meta-analysis of single-dose oral tramadol plus acetaminophen in acute postoperative pain. J Pain Symptom Manage. 2002;23:121–30.CrossRefPubMed
25.
go back to reference Schultz S, Desilva M, Gu TT, Qiang M, Whang K. Effects of the Analgesic Acetaminophen (Paracetamol) and its para-Aminophenol Metabolite on Viability of Mouse-Cultured Cortical Neurons. Basic Clin Pharmacol Toxicol. 2012;110:141–4.CrossRefPubMed Schultz S, Desilva M, Gu TT, Qiang M, Whang K. Effects of the Analgesic Acetaminophen (Paracetamol) and its para-Aminophenol Metabolite on Viability of Mouse-Cultured Cortical Neurons. Basic Clin Pharmacol Toxicol. 2012;110:141–4.CrossRefPubMed
26.
go back to reference Chan FK, Hung LC, Suen BY, Wu JC, Lee KC, Leung VK, et al. Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis. N Engl J Med. 2002;347:2104–10.CrossRefPubMed Chan FK, Hung LC, Suen BY, Wu JC, Lee KC, Leung VK, et al. Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis. N Engl J Med. 2002;347:2104–10.CrossRefPubMed
27.
go back to reference Ba YF, Li XD, Zhang X, Ning ZH, Zhang H, Liu YN et al. Comparison of the analgesic effects of cryoanalgesia vs. parecoxib for lung cancer patients after lobectomy. Surg Today. 2014 (in press). Ba YF, Li XD, Zhang X, Ning ZH, Zhang H, Liu YN et al. Comparison of the analgesic effects of cryoanalgesia vs. parecoxib for lung cancer patients after lobectomy. Surg Today. 2014 (in press).
28.
go back to reference Marret E, Remy C, Bonnet F. Meta-analysis of epidural analgesia versus parenteral opioid analgesia after colorectal surgery. Br J Surg. 2007;94:665–73.CrossRefPubMed Marret E, Remy C, Bonnet F. Meta-analysis of epidural analgesia versus parenteral opioid analgesia after colorectal surgery. Br J Surg. 2007;94:665–73.CrossRefPubMed
30.
go back to reference Veldkamp R, Gholghesaei M, Bonjer HJ, Meijer DW, Buunen M, Jeekel J, et al. Laparoscopic resection of colon Cancer: consensus of the European Association of Endoscopic Surgery (EAES). Surg Endosc. 2004;18:1163–85.CrossRefPubMed Veldkamp R, Gholghesaei M, Bonjer HJ, Meijer DW, Buunen M, Jeekel J, et al. Laparoscopic resection of colon Cancer: consensus of the European Association of Endoscopic Surgery (EAES). Surg Endosc. 2004;18:1163–85.CrossRefPubMed
31.
go back to reference Roscoe JA, Heckler CE, Morrow GR, Mohile SG, Dakhil SR, Wade JL, et al. Prevention of delayed nausea: a University of Rochester Cancer Center Community Clinical Oncology Program study of patients receiving chemotherapy. J Clin Oncol. 2012;30:3389–95.PubMedCentralCrossRefPubMed Roscoe JA, Heckler CE, Morrow GR, Mohile SG, Dakhil SR, Wade JL, et al. Prevention of delayed nausea: a University of Rochester Cancer Center Community Clinical Oncology Program study of patients receiving chemotherapy. J Clin Oncol. 2012;30:3389–95.PubMedCentralCrossRefPubMed
Metadata
Title
Novel management of postoperative pain using only oral analgesics after LADG
Authors
Jota Mikami
Shuji Takiguchi
Yasuhiro Miyazaki
Tsuyoshi Takahashi
Yukinori Kurokawa
Makoto Yamasaki
Hiroshi Miyata
Kiyokazu Nakajima
Masaki Mori
Yuichiro Doki
Publication date
01-01-2016
Publisher
Springer Japan
Published in
Surgery Today / Issue 1/2016
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-015-1155-x

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