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Published in: Surgery Today 9/2014

01-09-2014 | Original Article

Early postoperative results for females undergoing isolated coronary artery bypass surgery: comparison of the pre- and postmenopausal periods

Authors: Mehmet Acıpayam, Hasan Uncu, Levent Altınay, Mustafa Hakan Zor, Pınar Doğan, Ibrahim Özsöyler

Published in: Surgery Today | Issue 9/2014

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Abstract

Purpose

In this retrospective study, we investigated the demographic data and evaluated our early postoperative results of premenopausal and postmenopausal females who underwent coronary artery bypass graft surgery (CABG).

Methods

A total of 730 female patients who underwent CABG between April 2004 and January 2012 were included in the study. Patients were divided into two groups based on whether they were pre- (group 1) or postmenopausal (group 2). The groups were compared in terms of the demographic and peri-operative parameters.

Results

Smoking and the preoperative hematocrit levels were higher in group 1, whereas the incidence of hypertension and obesity and the European system for cardiac operative risk evaluation values were higher in group 2 (p values <0.01; <0.01; <0.01; 0.004 and <0.01 respectively). The utilization of a left internal mammary artery graft and the postoperative drainage volumes were higher in group 1; however, the number of grafts per patient, cardiopulmonary bypass duration, number of patients who needed inotropic support, blood transfusion volumes, the duration of ventilatory support and the hospital stay were higher in group 2 (p values 0.038; 0.040; 0.026; 0.032; 0.014; 0.001; <0.01 and <0.01, respectively).

Conclusions

Although the mortality rates were not significantly different, postmenopausal patients require more intensive postoperative care in comparison to premenopausal patients following CABG.
Literature
1.
3.
go back to reference Edwards FH, Carey JS, Grover FL, Bero JW, Hartz RS. Impact of gender on coronary bypass operative mortality. Ann Thorac Surg. 1998;6:125–31.CrossRef Edwards FH, Carey JS, Grover FL, Bero JW, Hartz RS. Impact of gender on coronary bypass operative mortality. Ann Thorac Surg. 1998;6:125–31.CrossRef
4.
go back to reference Lawton JS, Brister SJ, Petro KR, Dullum M. Surgical revascularization in women: unique intraoperative factors and considerations. J Thorac Cardiovasc Surg. 2003;126:936–8.PubMedCrossRef Lawton JS, Brister SJ, Petro KR, Dullum M. Surgical revascularization in women: unique intraoperative factors and considerations. J Thorac Cardiovasc Surg. 2003;126:936–8.PubMedCrossRef
5.
go back to reference Abramov D, Tamariz MG, Sever JY, et al. The influence of gender on the outcome of coronary artery bypass surgery. Ann Thorac Surg. 2000;70:800–5.PubMedCrossRef Abramov D, Tamariz MG, Sever JY, et al. The influence of gender on the outcome of coronary artery bypass surgery. Ann Thorac Surg. 2000;70:800–5.PubMedCrossRef
6.
go back to reference Vaccarino V, Abramson JL, Veledar E, Weintraub WS. Sex differences in hospital mortality after coronary artery bypass surgery: evidence for a higher mortality in younger women. Circulation. 2002;105:1176–81.PubMedCrossRef Vaccarino V, Abramson JL, Veledar E, Weintraub WS. Sex differences in hospital mortality after coronary artery bypass surgery: evidence for a higher mortality in younger women. Circulation. 2002;105:1176–81.PubMedCrossRef
8.
go back to reference Alam M, Lee VV, Elayda MA et al. Association of gender with morbidity and mortality after isolated coronary artery bypass grafting. A propensity score matched analysis. Int J Cardiol. 2012 (Epub ahead of print). Alam M, Lee VV, Elayda MA et al. Association of gender with morbidity and mortality after isolated coronary artery bypass grafting. A propensity score matched analysis. Int J Cardiol. 2012 (Epub ahead of print).
9.
go back to reference Kim C, Redberg RF, Pavlic T, Eagle KA. A systematic review of gender differences in mortality after coronary artery bypass graft surgery and percutaneous coronary interventions. Clin Cardiol. 2007;30:491–5.PubMedCrossRef Kim C, Redberg RF, Pavlic T, Eagle KA. A systematic review of gender differences in mortality after coronary artery bypass graft surgery and percutaneous coronary interventions. Clin Cardiol. 2007;30:491–5.PubMedCrossRef
10.
go back to reference Selam B, Topçuoğlu A. Menopozda Hormon Replasman Tedavisi Kullanımı ile İlgili Tartışmalar ve Güncel Yaklaşım. Düzce Tıp Fakültesi Dergisi. 2004;3:38–43. Selam B, Topçuoğlu A. Menopozda Hormon Replasman Tedavisi Kullanımı ile İlgili Tartışmalar ve Güncel Yaklaşım. Düzce Tıp Fakültesi Dergisi. 2004;3:38–43.
11.
go back to reference Neslihan Carda S, Bilge SA, Oztürk TN, Oya G, Ece O, Hamiyet B. The menopausal age, related factors and climacteric symptoms in Turkish women. Maturitas. 1998;30:37–40.PubMedCrossRef Neslihan Carda S, Bilge SA, Oztürk TN, Oya G, Ece O, Hamiyet B. The menopausal age, related factors and climacteric symptoms in Turkish women. Maturitas. 1998;30:37–40.PubMedCrossRef
12.
go back to reference Nashef SA, Roques F, Michel P, Gauducheau E, Lemeshow S, Salamon R. European system for cardiac operative risk evaluation (EuroSCORE). Eur J Cardiothorac Surg. 1999;16:9–13.PubMedCrossRef Nashef SA, Roques F, Michel P, Gauducheau E, Lemeshow S, Salamon R. European system for cardiac operative risk evaluation (EuroSCORE). Eur J Cardiothorac Surg. 1999;16:9–13.PubMedCrossRef
14.
go back to reference Khan SS, Nessim S, Gray R, Czer LS, Chaux A, Matloff I. Increased mortality of women in coronary artery bypass surgery: evidence for referral bias. Ann Intern Med. 1990;112:561–7.PubMed Khan SS, Nessim S, Gray R, Czer LS, Chaux A, Matloff I. Increased mortality of women in coronary artery bypass surgery: evidence for referral bias. Ann Intern Med. 1990;112:561–7.PubMed
15.
go back to reference Tyras DH, Barner HB, Kaiser GC, Codd JE, Laks H, Willman VL. Myocardial revascularization in women. Ann Thorac Surg. 1978;25:449–53.PubMedCrossRef Tyras DH, Barner HB, Kaiser GC, Codd JE, Laks H, Willman VL. Myocardial revascularization in women. Ann Thorac Surg. 1978;25:449–53.PubMedCrossRef
16.
go back to reference Blankstein R, Ward RP, Arnsdorf M, Jones B, Lou YB, Pine M. Female gender is an independent predictor of operative mortality after coronary artery bypass graft surgery: contemporary analysis of 31 Midwestern hospitals. Circulation. 2005;112(9 Suppl):I323–7.PubMed Blankstein R, Ward RP, Arnsdorf M, Jones B, Lou YB, Pine M. Female gender is an independent predictor of operative mortality after coronary artery bypass graft surgery: contemporary analysis of 31 Midwestern hospitals. Circulation. 2005;112(9 Suppl):I323–7.PubMed
17.
go back to reference Matthews KA, Meilahn E, Kuller LH, Kelsey SF, Caggiula AW, Wing RR. Menopause and risk factors for coronary heart disease. N Engl J Med. 1989;321:641–6.PubMedCrossRef Matthews KA, Meilahn E, Kuller LH, Kelsey SF, Caggiula AW, Wing RR. Menopause and risk factors for coronary heart disease. N Engl J Med. 1989;321:641–6.PubMedCrossRef
18.
go back to reference Stampfer MJ, Colditz GA. Estrogen replacement therapy and coronary heart disease: a quantitative assessment of the epidemiologic evidence. Prev Med. 1991;20:47–63.PubMedCrossRef Stampfer MJ, Colditz GA. Estrogen replacement therapy and coronary heart disease: a quantitative assessment of the epidemiologic evidence. Prev Med. 1991;20:47–63.PubMedCrossRef
19.
go back to reference Bairey Merz CN, Johnson BD, Sharaf BL, Bittner V, Berga SL, Braunstein GD, et al. Hypoestrogenemia of hypothalamic origin and coronary artery disease in premenopausal women: a report from the NHLBI-sponsored WISE study. J Am Coll Cardiol. 2003;41(3):413–9.PubMedCrossRef Bairey Merz CN, Johnson BD, Sharaf BL, Bittner V, Berga SL, Braunstein GD, et al. Hypoestrogenemia of hypothalamic origin and coronary artery disease in premenopausal women: a report from the NHLBI-sponsored WISE study. J Am Coll Cardiol. 2003;41(3):413–9.PubMedCrossRef
20.
go back to reference Waters D, Higginson L, Gladstone P, Boccuzzi SJ, Cook T, Lespérance J. Effects of cholesterol lowering on the progression of coronary atherosclerosis in women. A Canadian coronary atherosclerosis intervention trial (CCAIT) substudy. Circulation. 1995;92:2404–10.PubMedCrossRef Waters D, Higginson L, Gladstone P, Boccuzzi SJ, Cook T, Lespérance J. Effects of cholesterol lowering on the progression of coronary atherosclerosis in women. A Canadian coronary atherosclerosis intervention trial (CCAIT) substudy. Circulation. 1995;92:2404–10.PubMedCrossRef
21.
go back to reference Tian R, Zhang SY, Tian Z, et al. Clinical manifestations of premenopausal women with coronary arterial disease. Zhonghua Xin Xue Guan Bing Za Zhi. 2009;37:334–8.PubMed Tian R, Zhang SY, Tian Z, et al. Clinical manifestations of premenopausal women with coronary arterial disease. Zhonghua Xin Xue Guan Bing Za Zhi. 2009;37:334–8.PubMed
22.
go back to reference Kortelainen ML, Huttunen P. Expression of estrogen receptors in the coronary arteries of young and premenopausal women in relation to central obesity. Int J Obes Relat Metab Disord. 2004;28:623–7.PubMedCrossRef Kortelainen ML, Huttunen P. Expression of estrogen receptors in the coronary arteries of young and premenopausal women in relation to central obesity. Int J Obes Relat Metab Disord. 2004;28:623–7.PubMedCrossRef
23.
go back to reference Dziuba M, Jander S, Zwolinski R, Chizynski K. Surgical revascularization of myocardium in population of young women. Is it a group of increased operative risk? Arch Med Sci. 2009;5(2):135–40. Dziuba M, Jander S, Zwolinski R, Chizynski K. Surgical revascularization of myocardium in population of young women. Is it a group of increased operative risk? Arch Med Sci. 2009;5(2):135–40.
24.
go back to reference Burke AP, Farb A, Malcolm GT, et al. Effect of risk factors on the mechanism of acute thrombosis and sudden coronary death in women. Circulation. 1998;97:2110–6.PubMedCrossRef Burke AP, Farb A, Malcolm GT, et al. Effect of risk factors on the mechanism of acute thrombosis and sudden coronary death in women. Circulation. 1998;97:2110–6.PubMedCrossRef
25.
26.
go back to reference Özberrak H, Şırlak M, Eryılmaz S, Taşöz R, Çorapçıoğlu T, Akalın H. Koroner bypass cerrahisi sonrasında gelişen mortalitenin oluşumunu etkileyen risk faktörleri. T Klin J Cardiovasc Surg. 2000;1:19–25. Özberrak H, Şırlak M, Eryılmaz S, Taşöz R, Çorapçıoğlu T, Akalın H. Koroner bypass cerrahisi sonrasında gelişen mortalitenin oluşumunu etkileyen risk faktörleri. T Klin J Cardiovasc Surg. 2000;1:19–25.
Metadata
Title
Early postoperative results for females undergoing isolated coronary artery bypass surgery: comparison of the pre- and postmenopausal periods
Authors
Mehmet Acıpayam
Hasan Uncu
Levent Altınay
Mustafa Hakan Zor
Pınar Doğan
Ibrahim Özsöyler
Publication date
01-09-2014
Publisher
Springer Japan
Published in
Surgery Today / Issue 9/2014
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-013-0756-5

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