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Surgery Today
Published in: Surgery Today 6/2014

01-06-2014 | Review Article

A worldwide trend of increasing primary adenocarcinoma of the lung

Authors: Haruhiko Nakamura, Hisashi Saji

Published in: Surgery Today | Issue 6/2014

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Abstract

The four major histological types of lung cancer are adenocarcinoma, squamous cell carcinoma (SQ), large cell carcinoma and small cell carcinoma. Over the past few decades, the incidence of lung adenocarcinoma has increased gradually in most countries as the most frequently occurring histological type, displacing SQ. Adenocarcinoma is the predominant type of lung cancer among lifelong non-smokers and among females. Especially in East Asian countries, the cause(s) of the increase in adenocarcinomas are not clear. Several genetic mutations specific to lung adenocarcinomas have been found, representing attractive targets for molecular therapy. Recently, the pathological classification of lung adenocarcinoma was revised by integrating the newer clinical and biological knowledge concerning this prevailing type. Additional epidemiological, pathological and genetic studies are required to better understand this type of lung cancer.
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Metadata
Title
A worldwide trend of increasing primary adenocarcinoma of the lung
Authors
Haruhiko Nakamura
Hisashi Saji
Publication date
01-06-2014
Publisher
Springer Japan
Published in
Surgery Today / Issue 6/2014
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-013-0636-z

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