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01-03-2014 | Original Article

Gender differences in prognosis after esophagectomy for esophageal cancer

Authors: Masaru Morita, Hajime Otsu, Hiroyuki Kawano, Yuta Kasagi, Yasue Kimura, Hiroshi Saeki, Koji Ando, Satoshi Ida, Eiji Oki, Eriko Tokunaga, Tetsuo Ikeda, Tetsuya Kusumoto, Yoshihiko Maehara

Published in: Surgery Today | Issue 3/2014

Abstract

Purpose

The purpose of this study was to clarify the gender differences in the prognosis, as well as mortality and morbidity, of patients who have undergone esophagectomy for esophageal cancer.

Methods

The clinical results of esophagectomy were compared between 975 male and 156 female patients with esophageal cancer.

Results

The male to female ratios of cervical and thoracic esophageal cancer were 1.87 and 7.38, respectively (P < 0.01). The incidence of preoperative comorbidities was 32.4 and 17.4 %, respectively, and the rates of both tobacco and alcohol abuse were significantly lower in the females than in the males. The mortality rate was lower in the females (3.8 %) than in the males (5.7 %), although the differences were not significant. The overall survival was significantly better in the female than in the male patients (P = 0.039). The 5- and 10-year overall survival rates were 32.6 and 20.5 % in the males and 39.5 and 32.5 % in the females, respectively. A multivariate analysis revealed gender to be an independent prognostic factor. However, no significant differences were recognized in disease-specific survival.

Conclusions

These results suggest that the prognosis of females with esophageal cancer is better than that of males after esophagectomy, most likely due to multiple clinical factors, such as a more favorable lifestyle and general status.

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Title: Gender differences in prognosis after esophagectomy for esophageal cancer
Authors: Masaru Morita
Hajime Otsu
Hiroyuki Kawano
Yuta Kasagi
Yasue Kimura
Hiroshi Saeki
Koji Ando
Satoshi Ida
Eiji Oki
Eriko Tokunaga
Tetsuo Ikeda
Tetsuya Kusumoto
Yoshihiko Maehara
Publication date: 01-03-2014
Publisher: Springer Japan
Published in: Surgery Today / Issue 3/2014
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-013-0573-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Gender differences in prognosis after esophagectomy for esophageal cancer

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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