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01-02-2013 | Case report

Composite small cell and mucinous carcinoma originating from the intrahepatic bile duct: report of a case

Authors: Toru Ikegami, Hiroto Kayashima, Noriaki Sadanaga, Shusuke Morizono, Akihiko Nakashima, Hiroshi Matsuura, Ken Shirabe, Yoshihiko Maehara

Published in: Surgery Today | Issue 2/2013

Abstract

The biliary tract is a very rare site for the occurrence of extrapulmonary small cell carcinoma. A 68-year-old Japanese female was being followed up for autoimmune hepatitis, and was referred to our hospital because segmental intrahepatic bile duct dilation was found on routine imaging studies, suggesting intrahepatic cholangiocarcinoma. She underwent left lobectomy of the liver and concomitant resection of the caudate lobe. Microscopic examination of the explanted liver showed a primary composite tumor comprising small cell and mucinous carcinomas that originated in the intrahepatic bile duct. Further immunohistochemical studies, including cytokeratin-19 and chromogranin-A staining, showed the two cellular components of the tumor to have similar characteristics. The amphicrine properties indicated that the tumor had a monoclonal origin but with biphenotypic differentiation, which was responsible for the histogenesis of this tumor.

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Title: Composite small cell and mucinous carcinoma originating from the intrahepatic bile duct: report of a case
Authors: Toru Ikegami
Hiroto Kayashima
Noriaki Sadanaga
Shusuke Morizono
Akihiko Nakashima
Hiroshi Matsuura
Ken Shirabe
Yoshihiko Maehara
Publication date: 01-02-2013
Publisher: Springer Japan
Published in: Surgery Today / Issue 2/2013
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-012-0331-5

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Composite small cell and mucinous carcinoma originating from the intrahepatic bile duct: report of a case

Abstract

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