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Acta Diabetologica

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01-06-2020 | Influenza Virus | Perspectives

Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic

Authors: Livio Luzi, Maria Grazia Radaelli

Published in: Acta Diabetologica | Issue 6/2020

Abstract

Aims

Analyze the relationship between obesity and influenza.

Methods

Basal hormone milieu, defective response of both innate and adaptive immune system and sedentariness are major determinants in the severity of influenza viral infection in obese patients. Being overweight not only increases the risk of infection and of complications for the single obese person, but a large prevalence of obese individuals within the population might increase the chance of appearance of more virulent viral strain, prolongs the virus shedding throughout the total population and eventually might increase overall mortality rate of an influenza pandemic.

Results

Waiting for the development of a vaccination against COVID-19, isolation of positive cases and social distancing are the primary interventions. Nonetheless, evidence from previous influenza pandemics suggests the following interventions aimed at improving immune response: (1) lose weight with a mild caloric restriction; (2) include AMPK activators and PPAR gamma activators in the drug treatment for obesity associated with diabetes; and (3) practice mild-to-moderate physical exercise.

Conclusions

Due to prolonged viral shedding, quarantine in obese subjects should likely be longer than normal weight individuals.

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Title: Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic
Authors: Livio Luzi
Maria Grazia Radaelli
Publication date: 01-06-2020
Publisher: Springer Milan
Keywords: Influenza Virus
Obesity
Obesity
Pioglitazone
Metformin
Influenza
COVID-19
Published in: Acta Diabetologica / Issue 6/2020
Print ISSN: 0940-5429
Electronic ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-020-01522-8

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Conclusions

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