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Open Access 01-05-2019 | Respiratory Microbiota | Review Article

Diet-induced metabolic changes of the human gut microbiome: importance of short-chain fatty acids, methylamines and indoles

Authors: Mohd Badrin Hanizam Abdul Rahim, Julien Chilloux, Laura Martinez-Gili, Ana L. Neves, Antonis Myridakis, Nigel Gooderham, Marc-Emmanuel Dumas

Published in: Acta Diabetologica | Issue 5/2019

Abstract

The human gut is a home for more than 100 trillion bacteria, far more than all other microbial populations resident on the body’s surface. The human gut microbiome is considered as a microbial organ symbiotically operating within the host. It is a collection of different cell lineages that are capable of communicating with each other and the host and has an ability to undergo self-replication for its repair and maintenance. As the gut microbiota is involved in many host processes including growth and development, an imbalance in its ecological composition may lead to disease and dysfunction in the human. Gut microbial degradation of nutrients produces bioactive metabolites that bind target receptors, activating signalling cascades, and modulating host metabolism. This review covers current findings on the nutritional and pharmacological roles of selective gut microbial metabolites, short-chain fatty acids, methylamines and indoles, as well as discussing nutritional interventions to modulate the microbiome.

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Title: Diet-induced metabolic changes of the human gut microbiome: importance of short-chain fatty acids, methylamines and indoles
Authors: Mohd Badrin Hanizam Abdul Rahim
Julien Chilloux
Laura Martinez-Gili
Ana L. Neves
Antonis Myridakis
Nigel Gooderham
Marc-Emmanuel Dumas
Publication date: 01-05-2019
Publisher: Springer Milan
Keyword: Respiratory Microbiota
Published in: Acta Diabetologica / Issue 5/2019
Print ISSN: 0940-5429
Electronic ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-019-01312-x

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