Brachial flow-mediated dilation predicts glycemia worsening in normoglycemic young subjects

Excerpt

Endothelial dysfunction (ED) is a common feature of type 2 diabetes (T2D) and cardiovascular disorders. ED is early detectable in subjects with either strong diabetes familiarity or cardiovascular risk factors who may develop overt diabetes later [1‐4]. Brachial flow-mediated dilatation (b-FMD) is a marker of in vivo endothelial dysfunction, and it is a simple no invasive method for identifying patients at risk of CV disease. Nevertheless, to our knowledge, a clear link between impaired endothelium-dependent vasodilation in vivo and hyperglycemia spillover has never been reported. To this purpose, we report here the relationship between fasting glycaemia values analyzed 10 years later and baseline endothelial dysfunction assessment in a group of normoglycemic subjects with and without familiarity for T2D [1‐3]. …