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Acta Diabetologica

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Open Access 01-01-2018 | Original Article

HLA, infections and inflammation in early stages of atherosclerosis in children with type 1 diabetes

Authors: Michal Odermarsky, Erkki Pesonen, Timo Sorsa, Åke Lernmark, Pirkko J. Pussinen, Petru Liuba

Published in: Acta Diabetologica | Issue 1/2018

Abstract

Aims

This prospective study focuses on risk factors for arterial damage in children with type 1 diabetes (T1D).

Methods

Eighty children and adolescents with T1D were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow-mediated dilatation (FMD) of the brachial artery, and plasma levels of matrix metalloproteinase (MMP)-8. All subjects were genotyped for HLA. The number of respiratory tract infections (RTI) during the past year was obtained by a questionnaire in 56 patients.

Results

cIMT progression, defined as percentage (%) change of cIMT from baseline, correlated inversely with the % changes of both CAC (p = 0.04, r = − 0.3; n = 62) and FMD (p = 0.03, r = − 0.3; n = 47). In multivariate analysis, RTI frequency correlated significantly with cIMT progression irrespective of age, diabetes duration, BMI, and HbA1c (p = 0.03, r = 0.3). When patients were divided in relation to RTI, the association of DQ2/8 with cIMT progression remained significant in patients with over three infections/year (p = 0.04, r = 0.3). During follow-up, the group of DQ2/8 patients with hsCRP > 1 mg/l showed significantly higher levels of plasma MMP-8 than the non-DQ2/8 group.

Conclusions

The diabetes-risk genotype DQ2/8 and systemic inflammation contribute to pro-atherosclerotic vascular changes in children and adolescents with T1D.

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Title: HLA, infections and inflammation in early stages of atherosclerosis in children with type 1 diabetes
Authors: Michal Odermarsky
Erkki Pesonen
Timo Sorsa
Åke Lernmark
Pirkko J. Pussinen
Petru Liuba
Publication date: 01-01-2018
Publisher: Springer Milan
Published in: Acta Diabetologica / Issue 1/2018
Print ISSN: 0940-5429
Electronic ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-017-1063-1

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