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Published in: Acta Diabetologica 3/2017

Open Access 01-03-2017 | Original Article

Is all hypoglycaemia treated as equal? An observational study of how the type of diabetes and treatment prescribed prior to admission influences quality of treatment of inpatient hypoglycaemia

Published in: Acta Diabetologica | Issue 3/2017

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Abstract

Aims

Inpatient hypoglycaemia is common and associated with adverse outcomes. There is often increased vigilance of hypoglycaemia in inpatients with type 1 diabetes (T1DM) compared to type 2 diabetes (T2DM). We aimed to investigate this apparent discrepancy, utilising the time to repeat (TTR) capillary blood glucose (CBG) measurement as a surrogate for engagement with guidelines stating that CBG should be rechecked following intervention within 15 min of an initial CBG of <4 mmol/L.

Methods

This is an observational study of inpatient CBG data from 8 hospitals over a 7-year period. A national diabetes registry allowed identification of individual’s diagnosis and diabetes therapy. For each initial (index) CBG, the TTR for individuals with T2DM—on insulin or sulphonylurea—was compared with the TTR for individuals with T1DM, using a t test for significance performed on log(TTR). The median TTR was plotted for each group per index CBG.

Results

In total, 1480,335 CBG measurements were obtained. A total of 26,664 were <4 mmol/L. The TTR in T2DM individuals on sulphonylurea was significantly greater than in T1DM individuals where index CBG was ≥2.3 mmol/L (except index CBG 2.6 mmol/L). For T2DM patients receiving insulin significance exists for index CBGs of ≥3.2 mmol/L.

Conclusions

This analysis suggests that quality of care of hypoglycaemia varies according to diagnosis and medication. The group with the highest TTR (T2DM sulphonylurea treated) are possibly the clinical group in whom hypoglycaemia is most concerning. These data therefore suggest a need for education and raising awareness within the inpatient nursing staff.
Literature
1.
go back to reference International Hypoglycaemia Study Group (2015) Minimizing hypoglycemia in diabetes. Diabetes Care 38:1583–1591CrossRef International Hypoglycaemia Study Group (2015) Minimizing hypoglycemia in diabetes. Diabetes Care 38:1583–1591CrossRef
2.
go back to reference Giorda CB, Ozzello A, Gentile S et al (2015) Incidence and risk factors for severe and symptomatic hypoglycemia in type 1 diabetes. Results of the HYPOS-1 study. Acta Diabetol 52:845–853CrossRefPubMed Giorda CB, Ozzello A, Gentile S et al (2015) Incidence and risk factors for severe and symptomatic hypoglycemia in type 1 diabetes. Results of the HYPOS-1 study. Acta Diabetol 52:845–853CrossRefPubMed
3.
go back to reference UK Hypoglycaemia Study Group (2007) Risk of hypoglycaemia in types 1 and 2 diabetes: effects of treatment modalities and their duration. Diabetologia 50:1140–1147CrossRef UK Hypoglycaemia Study Group (2007) Risk of hypoglycaemia in types 1 and 2 diabetes: effects of treatment modalities and their duration. Diabetologia 50:1140–1147CrossRef
4.
go back to reference Hanefeld M, Frier BM, Pistrosch F (2016) Hypoglycemia and cardiovascular Risk: Is There a Major Link? Diabetes Care 39(Suppl 2):S205–S209CrossRefPubMed Hanefeld M, Frier BM, Pistrosch F (2016) Hypoglycemia and cardiovascular Risk: Is There a Major Link? Diabetes Care 39(Suppl 2):S205–S209CrossRefPubMed
5.
go back to reference Khunti K, Davies M, Majeed A et al (2015) Hypoglycemia and risk of cardiovascular disease and all-cause mortality in insulin-treated people with type 1 and type 2 diabetes: a cohort study. Diabetes Care 38:316–322CrossRefPubMed Khunti K, Davies M, Majeed A et al (2015) Hypoglycemia and risk of cardiovascular disease and all-cause mortality in insulin-treated people with type 1 and type 2 diabetes: a cohort study. Diabetes Care 38:316–322CrossRefPubMed
6.
go back to reference Nicolucci A, Kovacs Burns K, Holt RIG et al (2013) Diabetes Attitudes, Wishes and Needs second study (DAWN2™): cross-national benchmarking of diabetes-related psychosocial outcomes for people with diabetes. Diabet Med 30:767–777CrossRefPubMed Nicolucci A, Kovacs Burns K, Holt RIG et al (2013) Diabetes Attitudes, Wishes and Needs second study (DAWN2™): cross-national benchmarking of diabetes-related psychosocial outcomes for people with diabetes. Diabet Med 30:767–777CrossRefPubMed
7.
go back to reference Nicolucci A, Pintaudi B, Rossi MC et al (2015) The social burden of hypoglycemia in the elderly. Acta Diabetol 52:677–685CrossRefPubMed Nicolucci A, Pintaudi B, Rossi MC et al (2015) The social burden of hypoglycemia in the elderly. Acta Diabetol 52:677–685CrossRefPubMed
8.
go back to reference Swanson CM, Potter DJ, Kongable GL, Cook CB (2011) Update on inpatient glycemic control in hospitals in the United States. Endocr Pract 17:853–861CrossRefPubMed Swanson CM, Potter DJ, Kongable GL, Cook CB (2011) Update on inpatient glycemic control in hospitals in the United States. Endocr Pract 17:853–861CrossRefPubMed
9.
go back to reference Jones GC, Casey H, Perry CG et al (2014) Trends in recorded capillary blood glucose and hypoglycaemia in hospitalised patients with diabetes. Diabetes Res Clin Pract 104:79–83CrossRefPubMed Jones GC, Casey H, Perry CG et al (2014) Trends in recorded capillary blood glucose and hypoglycaemia in hospitalised patients with diabetes. Diabetes Res Clin Pract 104:79–83CrossRefPubMed
10.
go back to reference Bersoux S, Cook CB, Kongable GL, Shu J (2013) Trends in glycemic control over a 2-year period in 126 US hospitals. J Hosp Med 8:121–125CrossRefPubMed Bersoux S, Cook CB, Kongable GL, Shu J (2013) Trends in glycemic control over a 2-year period in 126 US hospitals. J Hosp Med 8:121–125CrossRefPubMed
11.
go back to reference Kerry C, Mitchell S, Sharma S et al (2013) Diurnal temporal patterns of hypoglycaemia in hospitalized people with diabetes may reveal potentially correctable factors. Diabet Med 30:1403–1406CrossRefPubMed Kerry C, Mitchell S, Sharma S et al (2013) Diurnal temporal patterns of hypoglycaemia in hospitalized people with diabetes may reveal potentially correctable factors. Diabet Med 30:1403–1406CrossRefPubMed
13.
go back to reference Deusenberry CM, Coley KC, Korytkowski MT, Donihi AC (2012) Hypoglycemia in hospitalized patients treated with sulfonylureas. Pharmacotherapy 32:613–617CrossRefPubMed Deusenberry CM, Coley KC, Korytkowski MT, Donihi AC (2012) Hypoglycemia in hospitalized patients treated with sulfonylureas. Pharmacotherapy 32:613–617CrossRefPubMed
14.
go back to reference Rajendran R, Kerry C, Rayman G, MaGIC study group (2014) Temporal patterns of hypoglycaemia and burden of sulfonylurea-related hypoglycaemia in UK hospitals: a retrospective multicentre audit of hospitalised patients with diabetes. BMJ Open 4:e005165CrossRefPubMedPubMedCentral Rajendran R, Kerry C, Rayman G, MaGIC study group (2014) Temporal patterns of hypoglycaemia and burden of sulfonylurea-related hypoglycaemia in UK hospitals: a retrospective multicentre audit of hospitalised patients with diabetes. BMJ Open 4:e005165CrossRefPubMedPubMedCentral
15.
go back to reference Turchin A, Matheny ME, Shubina M et al (2009) Hypoglycemia and clinical outcomes in patients with diabetes hospitalized in the general ward. Diabetes Care 32:1153–1157CrossRefPubMedPubMedCentral Turchin A, Matheny ME, Shubina M et al (2009) Hypoglycemia and clinical outcomes in patients with diabetes hospitalized in the general ward. Diabetes Care 32:1153–1157CrossRefPubMedPubMedCentral
16.
go back to reference Nirantharakumar K, Marshall T, Kennedy A et al (2012) Hypoglycaemia is associated with increased length of stay and mortality in people with diabetes who are hospitalized. Diabet Med 29:e445–e448CrossRefPubMed Nirantharakumar K, Marshall T, Kennedy A et al (2012) Hypoglycaemia is associated with increased length of stay and mortality in people with diabetes who are hospitalized. Diabet Med 29:e445–e448CrossRefPubMed
17.
go back to reference McEwan P, Larsen Thorsted B, Wolden M et al (2015) Healthcare resource implications of hypoglycemia-related hospital admissions and inpatient hypoglycemia: retrospective record-linked cohort studies in England. BMJ Open Diabetes Res Care 3:e000057CrossRefPubMedPubMedCentral McEwan P, Larsen Thorsted B, Wolden M et al (2015) Healthcare resource implications of hypoglycemia-related hospital admissions and inpatient hypoglycemia: retrospective record-linked cohort studies in England. BMJ Open Diabetes Res Care 3:e000057CrossRefPubMedPubMedCentral
18.
go back to reference Tan HK, Flanagan D (2013) The impact of hypoglycaemia on patients admitted to hospital with medical emergencies. Diabet Med 30:574–580CrossRefPubMed Tan HK, Flanagan D (2013) The impact of hypoglycaemia on patients admitted to hospital with medical emergencies. Diabet Med 30:574–580CrossRefPubMed
19.
go back to reference Tsujimoto T, Yamamoto-Honda R, Kajio H et al (2015) Prediction of 90-day mortality in patients without diabetes by severe hypoglycemia: blood glucose level as a novel marker of severity of underlying disease. Acta Diabetol 52:307–314CrossRefPubMed Tsujimoto T, Yamamoto-Honda R, Kajio H et al (2015) Prediction of 90-day mortality in patients without diabetes by severe hypoglycemia: blood glucose level as a novel marker of severity of underlying disease. Acta Diabetol 52:307–314CrossRefPubMed
21.
go back to reference Jones GC, Perry CG, Monaghan A et al (2015) Capillary blood glucose monitoring, inpatient hypoglycaemia and quality of care. Br J Diabetes 15:24–26CrossRef Jones GC, Perry CG, Monaghan A et al (2015) Capillary blood glucose monitoring, inpatient hypoglycaemia and quality of care. Br J Diabetes 15:24–26CrossRef
22.
go back to reference George JT, Warriner D, McGrane DJ et al (2011) Lack of confidence among trainee doctors in the management of diabetes: the Trainees Own Perception of Delivery of Care (TOPDOC) Diabetes Study. QJM 104:761–766CrossRefPubMedPubMedCentral George JT, Warriner D, McGrane DJ et al (2011) Lack of confidence among trainee doctors in the management of diabetes: the Trainees Own Perception of Delivery of Care (TOPDOC) Diabetes Study. QJM 104:761–766CrossRefPubMedPubMedCentral
23.
go back to reference Donnelly LA, Morris AD, Frier BM et al (2005) Frequency and predictors of hypoglycaemia in Type 1 and insulin-treated Type 2 diabetes: a population-based study. Diabet Med 22:749–755CrossRefPubMed Donnelly LA, Morris AD, Frier BM et al (2005) Frequency and predictors of hypoglycaemia in Type 1 and insulin-treated Type 2 diabetes: a population-based study. Diabet Med 22:749–755CrossRefPubMed
24.
go back to reference Braatvedt GD, Sykes AJ, Panossian Z, McNeill D (2014) The clinical course of patients with type 2 diabetes presenting to the hospital with sulfonylurea-induced hypoglycemia. Diabetes Technol Ther 16:661–666CrossRefPubMed Braatvedt GD, Sykes AJ, Panossian Z, McNeill D (2014) The clinical course of patients with type 2 diabetes presenting to the hospital with sulfonylurea-induced hypoglycemia. Diabetes Technol Ther 16:661–666CrossRefPubMed
25.
go back to reference Boucai L, Southern WN, Zonszein J (2011) Hypoglycemia-associated mortality is not drug-associated but linked to comorbidities. Am J Med 124:1028–1035CrossRefPubMedPubMedCentral Boucai L, Southern WN, Zonszein J (2011) Hypoglycemia-associated mortality is not drug-associated but linked to comorbidities. Am J Med 124:1028–1035CrossRefPubMedPubMedCentral
26.
go back to reference Hanefeld M, Duetting E, Bramlage P (2013) Cardiac implications of hypoglycaemia in patients with diabetes—a systematic review. Cardiovasc Diabetol 12:1–11CrossRef Hanefeld M, Duetting E, Bramlage P (2013) Cardiac implications of hypoglycaemia in patients with diabetes—a systematic review. Cardiovasc Diabetol 12:1–11CrossRef
Metadata
Title
Is all hypoglycaemia treated as equal? An observational study of how the type of diabetes and treatment prescribed prior to admission influences quality of treatment of inpatient hypoglycaemia
Publication date
01-03-2017
Published in
Acta Diabetologica / Issue 3/2017
Print ISSN: 0940-5429
Electronic ISSN: 1432-5233
DOI
https://doi.org/10.1007/s00592-016-0940-3

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