Published in:
01-12-2016 | Short Communication
Urinary albumin excretion correlates with carotid intima-media thickness in offspring of patients with type 2 diabetes and albuminuria
Authors:
Simonetta Bacci, Alessia Gargano, Antonia di Lorenzo, Angela De Matthaeis, Pamela Piscitelli, Antonio Pacilli, Gianluigi Vendemiale, Salvatore De Cosmo
Published in:
Acta Diabetologica
|
Issue 6/2016
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Excerpt
A large body of evidences indicates albuminuria as a strong predictor of cardiovascular disease (CVD) both in diabetic and in non-diabetic subjects [
1‐
3]. The basic mechanisms of the link between albuminuria and CVD are not completely understood, but this relationship is widely considered to reflect the common underlying pathology of endothelial dysfunction [
3]. It is also well known that the link with CVD may occur even in the presence of urinary albumin excretion (UAE) within the normal range [
1,
2]. Moreover, albuminuria correlates with carotid intima-media thickness (cIMT), hallmark of subclinical atherosclerosis and predictor for CVD [
4]. It has been shown that the presence of type 2 diabetes (T2DM) in parents plays a role on the development of cIMT in offspring glucose-tolerant young adults [
5]. However, it is not clear whether the presence of albuminuria in T2DM parents modulates the association between UAE and cIMT in their offspring. …
