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Acta Diabetologica
Published in: Acta Diabetologica 1/2016

01-02-2016 | Letter to the Editor

Chronic inflammation in offspring of patients with type 2 diabetes and albuminuria

Authors: Angela De Matthaeis, Antonia Di Lorenzo, Alessia Gargano, Gianluigi Vendemiale, Simonetta Bacci, Salvatore De Cosmo

Published in: Acta Diabetologica | Issue 1/2016

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Excerpt

Albuminuria, a key feature of diabetic nephropathy, is one of the strongest predictors of cardiovascular events in patients with type 2 diabetes (T2DM) [1]. Moreover, it is well known the role for chronic inflammation (CI) as underlying pathogenic mechanism of atherosclerosis in non-diabetic and diabetic subjects. Recent evidences show that CI is also as a potential mediator between albuminuria and macrovascular disease [2]. Fibrinogen and C-reactive protein (CRP), both markers of inflammatory response, are consistently associated with the future cardiovascular events also in apparently healthy individuals [3]. …
Literature
1.
Mattock MB, Morrish NJ, Viberti GC et al (1992) Prospective study of microalbuminuria as predictor of mortality in NIDDM. Diabetes 41:735–741CrossRef
2.
Festa A, D’Agostino R Jr, Howard G et al (2000) Inflammation and microalbuminuria in nondiabetic and type 2 diabetic subjects: the Insulin Resistance Atherosclerosis Study. Kidney Intern. 58:1703–1710CrossRef
3.
Collaboration Emerging Risk Factors, Kaptoge S, Di Angelantonio E, Pennells L et al (2012) C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med 367:1310–1320CrossRef
4.
Ruotsalainen E, Salmenniemi U, Vauhkonen I et al (2006) Changes in inflammatory citokines are related to impaired glucose tolerance in offspring of type 2 diabetic subjects. Diabetes Care 29:2714–2720CrossRefPubMed
5.
Tesauro M, Rizza S, Iantorno M et al (2007) Vascular, metabolic and inflammatory abnormalities in normoglycemic offspring of patients with type 2 diabetes mellitus. Metabolism 56:413–419CrossRefPubMed
Metadata
Title
Chronic inflammation in offspring of patients with type 2 diabetes and albuminuria
Authors
Angela De Matthaeis
Antonia Di Lorenzo
Alessia Gargano
Gianluigi Vendemiale
Simonetta Bacci
Salvatore De Cosmo
Publication date
01-02-2016
Publisher
Springer Milan
Published in
Acta Diabetologica / Issue 1/2016
Print ISSN: 0940-5429
Electronic ISSN: 1432-5233
DOI
https://doi.org/10.1007/s00592-015-0747-7

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