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Published in: Acta Diabetologica 2/2012

01-04-2012 | Original Article

Insulin resistance is independently associated with peripheral and autonomic neuropathy in Korean type 2 diabetic patients

Authors: Kee Ook Lee, Ji Sun Nam, Chul Woo Ahn, Ji-Man Hong, Seung-Min Kim, Il-Nam Sunwoo, Joon-Shik Moon, Sang-Jun Na, Young-Chul Choi

Published in: Acta Diabetologica | Issue 2/2012

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Abstract

In addition to chronic hyperglycemia, insulin resistance itself has been proposed to cause a diabetic neuropathy. We evaluated the role of insulin resistance in the pathogenesis of peripheral and autonomic neuropathy in patients with type 2 diabetes. Eighty-six patients with type 2 diabetes were evaluated for the anthropometric and biochemical profiles, and Kitt value was calculated from insulin tolerance test to assess the insulin resistance. Various autonomic function tests, nerve conduction velocity, and quantitative sensory tests were performed to assess autonomic and peripheral neuropathy. In univariate analysis, both autonomic and peripheral neuropathy were significantly associated with glycemic exposure index (GE index), HDL-cholesterol, duration of DM, and Kitt value. In stepwise linear regression analysis, GE index was an independent predictor of autonomic and peripheral neuropathy (β = 0.643, P < 0.001; β = 0.207, P = 0.013, respectively), and Kitt value was also an independent factor for the autonomic and peripheral neuropathy (β = − 0.306, P < 0.001; β = − 0.329, P < 0.001, respectively). Low HDL-cholesterol increased the odds ratio for peripheral neuropathy. Insulin resistance is independently associated with peripheral and autonomic neuropathy in Korean Type 2 diabetic patients along with hyperglycemia and HDL-cholesterol.
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Metadata
Title
Insulin resistance is independently associated with peripheral and autonomic neuropathy in Korean type 2 diabetic patients
Authors
Kee Ook Lee
Ji Sun Nam
Chul Woo Ahn
Ji-Man Hong
Seung-Min Kim
Il-Nam Sunwoo
Joon-Shik Moon
Sang-Jun Na
Young-Chul Choi
Publication date
01-04-2012
Publisher
Springer Milan
Published in
Acta Diabetologica / Issue 2/2012
Print ISSN: 0940-5429
Electronic ISSN: 1432-5233
DOI
https://doi.org/10.1007/s00592-010-0176-6

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