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Published in: Acta Diabetologica 3/2009

01-09-2009 | Original Article

Prevalence of diagnosed and undiagnosed diabetes mellitus and impaired fasting glucose in Sardinia

Authors: Sa. Muntoni, L. Atzori, R. Mereu, A. Manca, G. Satta, A. Gentilini, P. Bianco, A. Baule, G. M. Baule, S. Muntoni

Published in: Acta Diabetologica | Issue 3/2009

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Abstract

We aimed at updating the prevalence of impaired fasting glucose (IFG) and of undiagnosed (UD) and diagnosed diabetes (DD) among the Sardinian population. The survey was carried out from 2002 to 2005 on 4.737 subjects aged 20–80+ years. IFG was diagnosed when blood glucose was 110–125 mg/dl; UD when it was ≥126 mg/dl in the absence of personal history of diabetes; DD when personal history was positive, irrespective of blood glucose value. Prevalence rates (%) were adjusted for age by direct method to the Italian 2001 population. IFG was diagnosed in 11% of the sample (9.88% in females and 12.24% in males); UD was found in 5.65% (5.20 and 6.15%, females and males, respectively), DD in 8.72% (6.74 and 10.05%); and total diabetes (TD), i.e. the sum of UD + DD, was 14.37% (12.93 and 15.07%, females and males, respectively). In Sardinia, in about 5 years there was an increase of IFG (+61.8%), UD (+56.9%), DD (+55.7%), and TD (+57.9%). Thus Sardinia participates in the worldwide increase in prevalence of diabetes and its microvascular, macrovascular, and socioeconomic consequences.
Literature
1.
go back to reference Onkamo P, Väänänen S, Karvonen M, Tuomilehto J (1999) Worldwide increase in incidence of type 1 diabetes: the analysis of data on published incidence trends. Diabetologia 42:1395–1405PubMedCrossRef Onkamo P, Väänänen S, Karvonen M, Tuomilehto J (1999) Worldwide increase in incidence of type 1 diabetes: the analysis of data on published incidence trends. Diabetologia 42:1395–1405PubMedCrossRef
2.
go back to reference Rosenbloom AL, Joe JR, Young RS, Winter WE (1999) Emerging epidemic of type 2 diabetes in youth. Diabetes Care 22:345–354PubMedCrossRef Rosenbloom AL, Joe JR, Young RS, Winter WE (1999) Emerging epidemic of type 2 diabetes in youth. Diabetes Care 22:345–354PubMedCrossRef
3.
go back to reference Pi-Sunyer FX (2002) The obesity epidemic: pathophysiology and consequences of obesity. Obes Res 10:97S–104SPubMedCrossRef Pi-Sunyer FX (2002) The obesity epidemic: pathophysiology and consequences of obesity. Obes Res 10:97S–104SPubMedCrossRef
4.
go back to reference Hu FB, Li TY, Colditz GA, Willett WC, Manson JE (2003) Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. JAMA 289:1785–1791PubMedCrossRef Hu FB, Li TY, Colditz GA, Willett WC, Manson JE (2003) Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. JAMA 289:1785–1791PubMedCrossRef
5.
go back to reference Haffner S (2006) Diabetes and the metabolic syndrome—when is it best to intervene to prevent? Atheroscler Suppl 7:3–10PubMedCrossRef Haffner S (2006) Diabetes and the metabolic syndrome—when is it best to intervene to prevent? Atheroscler Suppl 7:3–10PubMedCrossRef
6.
go back to reference Muntoni Sa, Stabilini L, Stabilini M, Mancosu G, Muntoni S (1995) Steadily high IDDM incidence over 4 years in Sardinia. Diabetes Care 18:1600–1601PubMedCrossRef Muntoni Sa, Stabilini L, Stabilini M, Mancosu G, Muntoni S (1995) Steadily high IDDM incidence over 4 years in Sardinia. Diabetes Care 18:1600–1601PubMedCrossRef
7.
go back to reference Muntoni Sa, Fonte MT, Stoduto bS, Marietti G, Bizzarri C, Crinò A, Ciampalini P, Multari G, Suppa MA, Matteoli MC, Lucentini L, Sebastiani LM, Visalli N, Pozzilli P, Boscherini B, Muntoni S (1997) Incidence of insulin-dependent diabetes mellitus among Sardinian-heritage children born in Lazio region, Italy. Lancet 349:160–162PubMedCrossRef Muntoni Sa, Fonte MT, Stoduto bS, Marietti G, Bizzarri C, Crinò A, Ciampalini P, Multari G, Suppa MA, Matteoli MC, Lucentini L, Sebastiani LM, Visalli N, Pozzilli P, Boscherini B, Muntoni S (1997) Incidence of insulin-dependent diabetes mellitus among Sardinian-heritage children born in Lazio region, Italy. Lancet 349:160–162PubMedCrossRef
8.
go back to reference Muntoni Sa, Cocco P, Aru G, Cucca F, Muntoni S (2000) Nutritional factors and worldwide incidence of childhood type 1 diabetes. Am J Clin Nutr 71:1525–1529PubMed Muntoni Sa, Cocco P, Aru G, Cucca F, Muntoni S (2000) Nutritional factors and worldwide incidence of childhood type 1 diabetes. Am J Clin Nutr 71:1525–1529PubMed
9.
go back to reference Muntoni S, Muntoni Sa (2006) Epidemiological association between some dietary habits and the increasing incidence of type 1 diabetes worldwide. Ann Nutr Metab 50:11–19PubMedCrossRef Muntoni S, Muntoni Sa (2006) Epidemiological association between some dietary habits and the increasing incidence of type 1 diabetes worldwide. Ann Nutr Metab 50:11–19PubMedCrossRef
10.
go back to reference Muntoni S, Pintus F, Mascia P, Pintus P, Cabiddu G, Tronci P, Ganga G (1988) Indagine epidemiologica sul diabete noto ed ignorato in Sardegna. Giorn Ital Diabetol 8:311–316 Muntoni S, Pintus F, Mascia P, Pintus P, Cabiddu G, Tronci P, Ganga G (1988) Indagine epidemiologica sul diabete noto ed ignorato in Sardegna. Giorn Ital Diabetol 8:311–316
11.
go back to reference Baule GM (2003) Epidemiology of diagnosed and undiagnosed diabetes, and of IFG in Sardinia. Ann Nutr Metab 47:240–241 Baule GM (2003) Epidemiology of diagnosed and undiagnosed diabetes, and of IFG in Sardinia. Ann Nutr Metab 47:240–241
12.
go back to reference ATS-Sardegna Gruppo di Ricerca (1987) I fattori di rischio dell’arteriosclerosi in Sardegna. Giorn Arterioscl 12:115–191 ATS-Sardegna Gruppo di Ricerca (1987) I fattori di rischio dell’arteriosclerosi in Sardegna. Giorn Arterioscl 12:115–191
13.
go back to reference Tenconi MT, Gianti A, Pretti G, Capuano V, Dormi A, Giampaoli S, Muntoni S, Muntoni Sa, Vanuzzo D, Pilotto L, Pannozzo F (2004) The CINDI health monitor survey. Health behaviour among the Italian adult population. Ital J Public Health 1:108–115 Tenconi MT, Gianti A, Pretti G, Capuano V, Dormi A, Giampaoli S, Muntoni S, Muntoni Sa, Vanuzzo D, Pilotto L, Pannozzo F (2004) The CINDI health monitor survey. Health behaviour among the Italian adult population. Ital J Public Health 1:108–115
14.
go back to reference Rinder P (1969) Determination of glucose in blood using glucose oxidase with an alternative oxygen receptor. Ann Clin Biochem 6:24–27 Rinder P (1969) Determination of glucose in blood using glucose oxidase with an alternative oxygen receptor. Ann Clin Biochem 6:24–27
15.
go back to reference Diagnosis Definition Classification of Diabetes Mellitus, its Complications (1999) Report of a WHO Consultation. Part 1: diagnosis and classification of diabetes mellitus. World Health Organization, Geneva Diagnosis Definition Classification of Diabetes Mellitus, its Complications (1999) Report of a WHO Consultation. Part 1: diagnosis and classification of diabetes mellitus. World Health Organization, Geneva
16.
go back to reference Expert Committee on the Diagnosis, Classification of Diabetes Mellitus (2003) Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 26:3160–3167CrossRef Expert Committee on the Diagnosis, Classification of Diabetes Mellitus (2003) Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 26:3160–3167CrossRef
17.
go back to reference Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jones DW, Materson BJ, Oparil S, Wright JT, Roccella EJ, The National High Blood Pressure Education Program Coordinating Committee (2003) The seventh report of the joint committee on prevention, detection, evaluation, and treatment of high blood pressure. The JNC 7 report. JAMA 19:2560–2572CrossRef Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jones DW, Materson BJ, Oparil S, Wright JT, Roccella EJ, The National High Blood Pressure Education Program Coordinating Committee (2003) The seventh report of the joint committee on prevention, detection, evaluation, and treatment of high blood pressure. The JNC 7 report. JAMA 19:2560–2572CrossRef
18.
go back to reference Expert Panel on Detection, Evaluation, Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2001) Executive summary of the third report on the national cholesterol education program (NCEP). JAMA 285:2486–2497CrossRef Expert Panel on Detection, Evaluation, Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2001) Executive summary of the third report on the national cholesterol education program (NCEP). JAMA 285:2486–2497CrossRef
19.
go back to reference Marcovina SM, Albers JJ, Henderson LO, Hannon WH (1993) International federation of clinical chemistry: standardization project for measurements of apolipoprotein A-1 and B-III. Comparability of apolipoprotein A-1 values by use of international reference material. Clin Chem 39:777–781 Marcovina SM, Albers JJ, Henderson LO, Hannon WH (1993) International federation of clinical chemistry: standardization project for measurements of apolipoprotein A-1 and B-III. Comparability of apolipoprotein A-1 values by use of international reference material. Clin Chem 39:777–781
20.
go back to reference Koschinsky ML, Marcovina SM (1997) Lipoprotein(a): structural implications for pathophysiology. Int J Clin Lab Res 27:14–23PubMedCrossRef Koschinsky ML, Marcovina SM (1997) Lipoprotein(a): structural implications for pathophysiology. Int J Clin Lab Res 27:14–23PubMedCrossRef
21.
go back to reference American Society of Human Genetics/American College of Medical Genetics Test, Technology Transfer Committee Working Group (1998) ASHG/ACMG statement. Measurement and use of total plasma homocysteine. Am J Human Genet 63:1541–1543CrossRef American Society of Human Genetics/American College of Medical Genetics Test, Technology Transfer Committee Working Group (1998) ASHG/ACMG statement. Measurement and use of total plasma homocysteine. Am J Human Genet 63:1541–1543CrossRef
22.
go back to reference Haltmayer M, Mueller T, Gegenhuber A, Poelz W (2004) Comparison of the automated AxSYM and ADVIA centaur immunoassays for homocysteine determination. Clin Lab 50:175–180PubMed Haltmayer M, Mueller T, Gegenhuber A, Poelz W (2004) Comparison of the automated AxSYM and ADVIA centaur immunoassays for homocysteine determination. Clin Lab 50:175–180PubMed
23.
go back to reference Muntoni Sa, Stabilini L, Stabilini M, Muntoni S (1999) Results of five-year community-based programme for cardiovascular disease prevention: the Ats-Sardegna campaign. Eur J Epidemiol 15:29–34PubMedCrossRef Muntoni Sa, Stabilini L, Stabilini M, Muntoni S (1999) Results of five-year community-based programme for cardiovascular disease prevention: the Ats-Sardegna campaign. Eur J Epidemiol 15:29–34PubMedCrossRef
24.
go back to reference SS/AF Software Procedure Guide (1999) Version 8, SAS Institute Inc, Cary SS/AF Software Procedure Guide (1999) Version 8, SAS Institute Inc, Cary
25.
go back to reference Wild S, Sicree R, Roglic G, King H, Green A (2004) Global prevalence of diabetes. Estimates for the year 2000 and projection for 2030. Diabetes Care 27:1047–1053PubMedCrossRef Wild S, Sicree R, Roglic G, King H, Green A (2004) Global prevalence of diabetes. Estimates for the year 2000 and projection for 2030. Diabetes Care 27:1047–1053PubMedCrossRef
26.
go back to reference Ylihärsilä H, Lindström J, Eriksson J, Jousilahti P, Valle TT, Sundvall J, Tuomilehto J (2005) Prevalence of diabetes and impaired glucose regulation in 45- to 64-year-old individuals in three areas of Finland. Diabet Med 22:88–91PubMedCrossRef Ylihärsilä H, Lindström J, Eriksson J, Jousilahti P, Valle TT, Sundvall J, Tuomilehto J (2005) Prevalence of diabetes and impaired glucose regulation in 45- to 64-year-old individuals in three areas of Finland. Diabet Med 22:88–91PubMedCrossRef
27.
go back to reference Tanne D, Koren-Morag N, Goldbourt U (2004) Fasting plasma glucose and risk of incident ischemic stroke or transient ischemic attacks: a prospective cohort study. Stroke 35:2351–2355PubMedCrossRef Tanne D, Koren-Morag N, Goldbourt U (2004) Fasting plasma glucose and risk of incident ischemic stroke or transient ischemic attacks: a prospective cohort study. Stroke 35:2351–2355PubMedCrossRef
28.
go back to reference Nichols GA, Hillier TA, Brown JB (2007) Progression from newly acquired impaired fasting glucose to type 2 diabetes. Diabetes Care 30:228–233PubMedCrossRef Nichols GA, Hillier TA, Brown JB (2007) Progression from newly acquired impaired fasting glucose to type 2 diabetes. Diabetes Care 30:228–233PubMedCrossRef
30.
go back to reference Gregg EW, Williams DE, Cadwell BL, Geiss L, Cheng YJ, Engelgau MM, Cowie CC, Vinicor F (2004) Trends in the prevalence and ratio of diagnosed to undiagnosed diabetes according to obesity levels in the US. Diabetes Care 27:2806–2812PubMedCrossRef Gregg EW, Williams DE, Cadwell BL, Geiss L, Cheng YJ, Engelgau MM, Cowie CC, Vinicor F (2004) Trends in the prevalence and ratio of diagnosed to undiagnosed diabetes according to obesity levels in the US. Diabetes Care 27:2806–2812PubMedCrossRef
31.
go back to reference Lammi N, Blomstedt PA, Moltchanova E, Eriksson JG, Tuomilehto J, Karvonen M (2008) Marked temporal increase in the incidence of type 1 and type 2 diabetes among young adults in Finland. Diabetologia 51:897–899PubMedCrossRef Lammi N, Blomstedt PA, Moltchanova E, Eriksson JG, Tuomilehto J, Karvonen M (2008) Marked temporal increase in the incidence of type 1 and type 2 diabetes among young adults in Finland. Diabetologia 51:897–899PubMedCrossRef
32.
go back to reference Boronat M, Varillas VF, Saavedra P, Suàrez V, Bosch E, Carrillo A, Nòvoa FJ (2006) Diabetes mellitus and impaired glucose regulation in the Canary Islands (Spain): prevalence and associated factors in the adult population of Telde, Gran Canaria. Diabet Med 23:148–155PubMedCrossRef Boronat M, Varillas VF, Saavedra P, Suàrez V, Bosch E, Carrillo A, Nòvoa FJ (2006) Diabetes mellitus and impaired glucose regulation in the Canary Islands (Spain): prevalence and associated factors in the adult population of Telde, Gran Canaria. Diabet Med 23:148–155PubMedCrossRef
Metadata
Title
Prevalence of diagnosed and undiagnosed diabetes mellitus and impaired fasting glucose in Sardinia
Authors
Sa. Muntoni
L. Atzori
R. Mereu
A. Manca
G. Satta
A. Gentilini
P. Bianco
A. Baule
G. M. Baule
S. Muntoni
Publication date
01-09-2009
Publisher
Springer Milan
Published in
Acta Diabetologica / Issue 3/2009
Print ISSN: 0940-5429
Electronic ISSN: 1432-5233
DOI
https://doi.org/10.1007/s00592-008-0081-4

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