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European Journal of Orthopaedic Surgery & Traumatology

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01-10-2018 | Original Article • HIP - ARTHROPLASTY

Matched cohort study of topical tranexamic acid in cementless primary total hip replacement

Authors: Javier Sanz-Reig, Jesus Mas Martinez, Carmen Verdu Román, Manuel Morales Santias, Enrique Martínez Gimenez, David Bustamante Suarez de Puga

Published in: European Journal of Orthopaedic Surgery & Traumatology | Issue 7/2018

Abstract

Purpose

Tranexamic acid has been shown to be effective in reducing blood loss after total hip replacement. The purpose of this study was to prospectively assess the effectiveness of topical TXA use to reduce blood loss after primary total hip replacement and to compare these outcomes with those of a matched control group from a similar cohort that did not have received tranexamic acid.

Methods

This is a prospective matched control study to assess the effect of a 2 g topical tranexamic acid in 50 mL physiological saline solution in total hip replacement. Primary outcomes were hemoglobin and hematocrit drop, and total blood loss. Secondary outcomes were transfusion rates, length of hospital stay, deep vein thrombosis, and pulmonary embolism events.

Results

We could match 100 patients to a control group. There were no statistical significantly differences between the two groups. The hemoglobin and hematocrit postoperative values were significantly higher in topical tranexamic acid group than in control group (P < 0.001). The mean total blood loss was 769 in topical tranexamic acid group and 1163 in control group with significant differences (P = 0.001), which meant 34% reduction in total blood loss. Length of stay was lower in topical tranexamic acid group. The risk of deep vein thrombosis and pulmonary events did not increase.

Conclusions

A single dose of 2 g tranexamic acid in 50 mL physiological saline solution topical administration was effective and safe in reducing bleeding in patients undergoing unilateral primary non-cemented total hip replacement compared to a matched control group.

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Title: Matched cohort study of topical tranexamic acid in cementless primary total hip replacement
Authors: Javier Sanz-Reig
Jesus Mas Martinez
Carmen Verdu Román
Manuel Morales Santias
Enrique Martínez Gimenez
David Bustamante Suarez de Puga
Publication date: 01-10-2018
Publisher: Springer Paris
Published in: European Journal of Orthopaedic Surgery & Traumatology / Issue 7/2018
Print ISSN: 1633-8065
Electronic ISSN: 1432-1068
DOI: https://doi.org/10.1007/s00590-018-2192-0

At a glance: The STEP trials

Springer Medicine

Matched cohort study of topical tranexamic acid in cementless primary total hip replacement

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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