Skip to main content
Top
Published in: European Journal of Orthopaedic Surgery & Traumatology 4/2017

01-05-2017 | Original Article • GENERAL ORTHOPAEDICS - PAEDIATRICS

Myositis ossificans in children: a review

Authors: N. K. Sferopoulos, R. Kotakidou, A. S. Petropoulos

Published in: European Journal of Orthopaedic Surgery & Traumatology | Issue 4/2017

Login to get access

Abstract

The formation of lamellar bone in the soft tissues, where bone normally does not exist, is called myositis ossificans. However, it would be more accurate to describe as myositis ossificans the involvement of skeletal muscles and as ectopic or heterotopic ossification the involvement of soft tissues in general. The lesion is subdivided in genetic and non-genetic or acquired types. Myositis or fibrodysplasia ossificans progressiva is a debilitating rare genetic disorder. Clinical suspicion of the disease in the newborn on the basis of malformed great toes may lead to early clinical diagnosis, confirmatory diagnostic genetic testing and avoidance of iatrogenic harmful procedures. Acquired lesions involve the neurogenic myositis ossificans and the non-neurogenic disorder. The latter is defined either as circumscribed myositis ossificans that is post-traumatic or as idiopathic/pseudomalignant myositis ossificans that is non-traumatic and may be a form fruste of fibrodysplasia ossificans progressiva. Ossification in fibrodysplasia ossificans progressiva is irreversible, unlike other forms of heterotopic ossification. In this retrospective study, a total of 22 children with myositis ossificans treated in a 20-year period were identified and classified. Two patients were diagnosed with myositis/fibrodysplasia ossificans progressiva, one with neurogenic myositis ossificans, one with idiopathic/pseudomalignant myositis ossificans and 18 patients with circumscribed myositis ossificans. The clinical features, imaging and histological findings as well as treatment modalities and complications of myositis ossificans in our patients are presented and discussed.
Literature
1.
go back to reference Chalmers J, Gray DH, Rush J (1975) Observations on the induction of bone in soft tissues. J Bone Joint Surg Br 57(1):36–45PubMed Chalmers J, Gray DH, Rush J (1975) Observations on the induction of bone in soft tissues. J Bone Joint Surg Br 57(1):36–45PubMed
2.
go back to reference Urist MR, Nakagawa M, Nakata N, Nogami H (1978) Experimental myositis ossificans: cartilage and bone formation in muscle in response to a diffusible bone matrix-derived morphogen. Arch Pathol Lab Med 102(6):312–316PubMed Urist MR, Nakagawa M, Nakata N, Nogami H (1978) Experimental myositis ossificans: cartilage and bone formation in muscle in response to a diffusible bone matrix-derived morphogen. Arch Pathol Lab Med 102(6):312–316PubMed
3.
go back to reference Puzas JE, Miller MD, Rosier RN (1989) Pathologic bone formation. Clin Orthop Relat Res 245:269–281 Puzas JE, Miller MD, Rosier RN (1989) Pathologic bone formation. Clin Orthop Relat Res 245:269–281
4.
go back to reference Garland DE (1991) A clinical perspective on common forms of acquired heterotopic ossification. Clin Orthop Relat Res 263:13–29 Garland DE (1991) A clinical perspective on common forms of acquired heterotopic ossification. Clin Orthop Relat Res 263:13–29
5.
go back to reference Hirano H, Urist MR (1991) Induced bone development in transplants of fresh human pseudomalignant heterotopic ossification tissue in athymic nude mice. Clin Orthop Relat Res 263:113–120 Hirano H, Urist MR (1991) Induced bone development in transplants of fresh human pseudomalignant heterotopic ossification tissue in athymic nude mice. Clin Orthop Relat Res 263:113–120
6.
go back to reference Reddi AH, Cunningham NS (1993) Initiation and promotion of bone differentiation by bone morphogenetic proteins. J Bone Miner Res 8(Suppl 2):S499–S502PubMed Reddi AH, Cunningham NS (1993) Initiation and promotion of bone differentiation by bone morphogenetic proteins. J Bone Miner Res 8(Suppl 2):S499–S502PubMed
7.
go back to reference Kaplan FS, Gannon FH, Hahn GV, Wollner N, Prauner R (1998) Pseudomalignant heterotopic ossification. Clin Orthop Relat Res 346:134–140 Kaplan FS, Gannon FH, Hahn GV, Wollner N, Prauner R (1998) Pseudomalignant heterotopic ossification. Clin Orthop Relat Res 346:134–140
8.
go back to reference Bosch P, Musgrave D, Ghivizzani S, Latterman C, Day CS, Huard J (2000) The efficiency of muscle-derived cell-mediated bone formation. Cell Transpl 9(4):463–470 Bosch P, Musgrave D, Ghivizzani S, Latterman C, Day CS, Huard J (2000) The efficiency of muscle-derived cell-mediated bone formation. Cell Transpl 9(4):463–470
9.
go back to reference Sykaras N, Opperman LA (2003) Bone morphogenetic proteins (BMPs): how do they function and what can they offer the clinician? J Oral Sci 45(2):57–73PubMedCrossRef Sykaras N, Opperman LA (2003) Bone morphogenetic proteins (BMPs): how do they function and what can they offer the clinician? J Oral Sci 45(2):57–73PubMedCrossRef
10.
go back to reference Kaplan FS, Glaser DL, Hebela N, Shore EM (2004) Heterotopic ossification. J Am Acad Orthop Surg 12(2):116–125PubMedCrossRef Kaplan FS, Glaser DL, Hebela N, Shore EM (2004) Heterotopic ossification. J Am Acad Orthop Surg 12(2):116–125PubMedCrossRef
11.
go back to reference Pape HC, Marsh S, Morley JR, Krettek C, Giannoudis PV (2004) Current concepts in the development of heterotopic ossification. J Bone Joint Surg Br 86(6):783–787PubMedCrossRef Pape HC, Marsh S, Morley JR, Krettek C, Giannoudis PV (2004) Current concepts in the development of heterotopic ossification. J Bone Joint Surg Br 86(6):783–787PubMedCrossRef
12.
go back to reference Vanden Bossche L, Vanderstraeten G (2005) Heterotopic ossification: a review. J Rehabil Med 37(3):129–136PubMedCrossRef Vanden Bossche L, Vanderstraeten G (2005) Heterotopic ossification: a review. J Rehabil Med 37(3):129–136PubMedCrossRef
13.
go back to reference McCarthy EF, Sundaram M (2005) Heterotopic ossification: a review. Skelet Radiol 34(10):609–619CrossRef McCarthy EF, Sundaram M (2005) Heterotopic ossification: a review. Skelet Radiol 34(10):609–619CrossRef
14.
go back to reference Elefteriou F (2005) Neuronal signaling and the regulation of bone remodeling. Cell Mol Life Sci 62(19–20):2339–2349PubMedCrossRef Elefteriou F (2005) Neuronal signaling and the regulation of bone remodeling. Cell Mol Life Sci 62(19–20):2339–2349PubMedCrossRef
18.
go back to reference Petropoulos AS, Sferopoulos NK (1997) Post-traumatic myositis ossificans of the iliopsoas muscle. Apropos of a case with review of the literature. Rev Chir Orthop Reparatrice Appar Mot 83(8):747–751PubMed Petropoulos AS, Sferopoulos NK (1997) Post-traumatic myositis ossificans of the iliopsoas muscle. Apropos of a case with review of the literature. Rev Chir Orthop Reparatrice Appar Mot 83(8):747–751PubMed
19.
go back to reference Sferopoulos NK, Anagnostopoulos D (1997) Ectopic bone formation in a child with a head injury: complete regression after immobilisation. Int Orthop 21(6):412–414PubMedCrossRef Sferopoulos NK, Anagnostopoulos D (1997) Ectopic bone formation in a child with a head injury: complete regression after immobilisation. Int Orthop 21(6):412–414PubMedCrossRef
20.
go back to reference Gilmer WS, Anderson LD (1959) Reactions of soft somatic tissue which may progress to bone formation: circumscribed (traumatic) myositis ossificans. South Med J 52:1432–1448CrossRef Gilmer WS, Anderson LD (1959) Reactions of soft somatic tissue which may progress to bone formation: circumscribed (traumatic) myositis ossificans. South Med J 52:1432–1448CrossRef
21.
go back to reference Rogers JG, Geho WB (1979) Fibrodysplasia ossificans progressiva. A survey of forty-two cases. J Bone Joint Surg Am 61:909–914PubMedCrossRef Rogers JG, Geho WB (1979) Fibrodysplasia ossificans progressiva. A survey of forty-two cases. J Bone Joint Surg Am 61:909–914PubMedCrossRef
22.
go back to reference Connor JM, Evans DA (1982) Fibrodysplasia ossificans progressiva. The clinical features and natural history of 34 patients. J Bone Joint Surg Br 64(1):76–83PubMed Connor JM, Evans DA (1982) Fibrodysplasia ossificans progressiva. The clinical features and natural history of 34 patients. J Bone Joint Surg Br 64(1):76–83PubMed
23.
go back to reference Cohen RB, Hahn GV, Tabas JA, Peeper J, Levitz CL, Sando A, Sando N, Zasloff M, Kaplan FS (1993) The natural history of heterotopic ossification in patients who have fibrodysplasia ossificans progressiva. A study of forty-four patients. J Bone Joint Surg Am 75(2):215–219PubMedCrossRef Cohen RB, Hahn GV, Tabas JA, Peeper J, Levitz CL, Sando A, Sando N, Zasloff M, Kaplan FS (1993) The natural history of heterotopic ossification in patients who have fibrodysplasia ossificans progressiva. A study of forty-four patients. J Bone Joint Surg Am 75(2):215–219PubMedCrossRef
24.
go back to reference Kaplan FS, Tabas JA, Gannon FH, Finkel G, Hahn GV, Zasloff MA (1993) The histopathology of fibrodysplasia ossificans progressiva. An endochondral process. J Bone Joint Surg Am 75(2):220–230PubMedCrossRef Kaplan FS, Tabas JA, Gannon FH, Finkel G, Hahn GV, Zasloff MA (1993) The histopathology of fibrodysplasia ossificans progressiva. An endochondral process. J Bone Joint Surg Am 75(2):220–230PubMedCrossRef
25.
go back to reference Shah PB, Zasloff MA, Drummond D, Kaplan FS (1994) Spinal deformity in patients who have fibrodysplasia ossificans progressiva. J Bone Joint Surg Am 76(10):1442–1450PubMedCrossRef Shah PB, Zasloff MA, Drummond D, Kaplan FS (1994) Spinal deformity in patients who have fibrodysplasia ossificans progressiva. J Bone Joint Surg Am 76(10):1442–1450PubMedCrossRef
26.
go back to reference Cottalorda J, Jouve JL, Bollini G, Brehier P, Daoud A, Muracciole P, Toth C (1995) Munchmeyer’s disease in children. Rev Chir Orthop Reparatrice Appar Mot 81(1):74–77PubMed Cottalorda J, Jouve JL, Bollini G, Brehier P, Daoud A, Muracciole P, Toth C (1995) Munchmeyer’s disease in children. Rev Chir Orthop Reparatrice Appar Mot 81(1):74–77PubMed
27.
go back to reference Lanchoney TF, Cohen RB, Rocke DM, Zasloff MA, Kaplan FS (1995) Permanent heterotopic ossification at the injection site after diphtheria-tetanus-pertussis immunizations in children who have fibrodysplasia ossificans progressiva. J Pediatr 126(5):762–764PubMedCrossRef Lanchoney TF, Cohen RB, Rocke DM, Zasloff MA, Kaplan FS (1995) Permanent heterotopic ossification at the injection site after diphtheria-tetanus-pertussis immunizations in children who have fibrodysplasia ossificans progressiva. J Pediatr 126(5):762–764PubMedCrossRef
28.
go back to reference Moriatis JM, Gannon FH, Shore EM, Bilker W, Zasloff MA, Kaplan FS (1997) Limb swelling in patients who have fibrodysplasia ossificans progressiva. Clin Orthop Relat Res 336:247–253CrossRef Moriatis JM, Gannon FH, Shore EM, Bilker W, Zasloff MA, Kaplan FS (1997) Limb swelling in patients who have fibrodysplasia ossificans progressiva. Clin Orthop Relat Res 336:247–253CrossRef
29.
go back to reference Smith R (1998) Fibrodysplasia (myositis) ossificans progressiva. Clinical lessons from a rare disease. Clin Orthop Relat Res 346:7–14CrossRef Smith R (1998) Fibrodysplasia (myositis) ossificans progressiva. Clinical lessons from a rare disease. Clin Orthop Relat Res 346:7–14CrossRef
30.
go back to reference Delatycki M, Rogers JG (1998) The genetics of fibrodysplasia ossificans progressiva. Clin Orthop Relat Res 346:15–18CrossRef Delatycki M, Rogers JG (1998) The genetics of fibrodysplasia ossificans progressiva. Clin Orthop Relat Res 346:15–18CrossRef
31.
go back to reference Brantus JF, Meunier PJ (1998) Effects of intravenous etidronate and oral corticosteroids in fibrodysplasia ossificans progressiva. Clin Orthop Relat Res 346:117–120CrossRef Brantus JF, Meunier PJ (1998) Effects of intravenous etidronate and oral corticosteroids in fibrodysplasia ossificans progressiva. Clin Orthop Relat Res 346:117–120CrossRef
32.
go back to reference Kitterman JA, Kantanie S, Rocke DM, Kaplan FS (2005) Iatrogenic harm caused by diagnostic errors in fibrodysplasia ossificans progressiva. Pediatrics 116(5):e654-e661CrossRef Kitterman JA, Kantanie S, Rocke DM, Kaplan FS (2005) Iatrogenic harm caused by diagnostic errors in fibrodysplasia ossificans progressiva. Pediatrics 116(5):e654-e661CrossRef
33.
go back to reference Shore EM, Xu M, Feldman GJ, Fenstermacher DA, Cho TJ, Choi IH, Connor JM, Delai P, Glaser DL, LeMerrer M, Morhart R, Rogers JG, Smith R, Triffitt JT, Urtizberea JA, Zasloff M, Brown MA, Kaplan FS (2006) A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nat Genet 38(5):525–527PubMedCrossRef Shore EM, Xu M, Feldman GJ, Fenstermacher DA, Cho TJ, Choi IH, Connor JM, Delai P, Glaser DL, LeMerrer M, Morhart R, Rogers JG, Smith R, Triffitt JT, Urtizberea JA, Zasloff M, Brown MA, Kaplan FS (2006) A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nat Genet 38(5):525–527PubMedCrossRef
34.
go back to reference Benetos IS, Mavrogenis AF, Themistocleous GS, Kanellopoulos AD, Papagelopoulos PJ, Soucacos PN (2006) Optimal treatment of fibrodysplasia ossificans progressiva with surgical excision of heterotopic bone, indomethacin, and irradiation. J Surg Orthop Adv 15(2):99–104PubMed Benetos IS, Mavrogenis AF, Themistocleous GS, Kanellopoulos AD, Papagelopoulos PJ, Soucacos PN (2006) Optimal treatment of fibrodysplasia ossificans progressiva with surgical excision of heterotopic bone, indomethacin, and irradiation. J Surg Orthop Adv 15(2):99–104PubMed
35.
go back to reference Kaplan FS, Glaser DL, Pignolo RJ, Shore EM (2007) A new era for fibrodysplasia ossificans progressiva: a druggable target for the second skeleton. Expert Opin Biol Ther 7(5):705–712PubMedCrossRef Kaplan FS, Glaser DL, Pignolo RJ, Shore EM (2007) A new era for fibrodysplasia ossificans progressiva: a druggable target for the second skeleton. Expert Opin Biol Ther 7(5):705–712PubMedCrossRef
39.
go back to reference Kaplan FS, Groppe J, Shore EM (2008) When one skeleton is enough: approaches and strategies for the treatment of fibrodysplasia ossificans progressiva (FOP). Drug Discov Today Ther Strateg 5(4):255–262PubMedPubMedCentralCrossRef Kaplan FS, Groppe J, Shore EM (2008) When one skeleton is enough: approaches and strategies for the treatment of fibrodysplasia ossificans progressiva (FOP). Drug Discov Today Ther Strateg 5(4):255–262PubMedPubMedCentralCrossRef
40.
42.
43.
go back to reference Kartal-Kaess M, Shore EM, Xu M, Schwering L, Uhl M, Korinthenberg R, Niemeyer C, Kaplan FS, Lauten M (2010) Fibrodysplasia ossificans progressiva (FOP): watch the great toes! Eur J Pediatr 169(11):1417–1421. doi:10.1007/s00431-010-1232-5 PubMedCrossRef Kartal-Kaess M, Shore EM, Xu M, Schwering L, Uhl M, Korinthenberg R, Niemeyer C, Kaplan FS, Lauten M (2010) Fibrodysplasia ossificans progressiva (FOP): watch the great toes! Eur J Pediatr 169(11):1417–1421. doi:10.​1007/​s00431-010-1232-5 PubMedCrossRef
45.
go back to reference Trigui M, Ayadi K, Zribi M, Triki Z, Keskes H (2011) Fibrodysplasia ossificans progressiva: diagnosis and surgical management. Acta Orthop Belg 77(2):139–144PubMed Trigui M, Ayadi K, Zribi M, Triki Z, Keskes H (2011) Fibrodysplasia ossificans progressiva: diagnosis and surgical management. Acta Orthop Belg 77(2):139–144PubMed
48.
go back to reference Shore EM (2012) Fibrodysplasia ossificans progressiva: a human genetic disorder of extraskeletal bone formation, or-how does one tissue become another? Wiley Interdiscip Rev Dev Biol 1(1):153–165PubMedPubMedCentralCrossRef Shore EM (2012) Fibrodysplasia ossificans progressiva: a human genetic disorder of extraskeletal bone formation, or-how does one tissue become another? Wiley Interdiscip Rev Dev Biol 1(1):153–165PubMedPubMedCentralCrossRef
49.
go back to reference Whyte MP, Wenkert D, Demertzis JL, DiCarlo EF, Westenberg E, Mumm S (2012) Fibrodysplasia ossificans progressiva: middle-age onset of heterotopic ossification from a unique missense mutation (c.974G > C, p. G325A) in ACVR1. J Bone Miner Res 27(3):729–737. doi:10.1002/jbmr.1473 PubMedCrossRef Whyte MP, Wenkert D, Demertzis JL, DiCarlo EF, Westenberg E, Mumm S (2012) Fibrodysplasia ossificans progressiva: middle-age onset of heterotopic ossification from a unique missense mutation (c.974G > C, p. G325A) in ACVR1. J Bone Miner Res 27(3):729–737. doi:10.​1002/​jbmr.​1473 PubMedCrossRef
50.
go back to reference Morales-Piga A, Bachiller-Corral J, Trujillo-Tiebas MJ, Villaverde-Hueso A, Gamir-Gamir ML, Alonso-Ferreira V, Vázquez-Díaz M, Posada de la Paz M, Ayuso-García C (2012) Fibrodysplasia ossificans progressiva in Spain: epidemiological, clinical, and genetic aspects. Bone 51(4):748–755. doi:10.1016/j.bone.2012.07.002 PubMedCrossRef Morales-Piga A, Bachiller-Corral J, Trujillo-Tiebas MJ, Villaverde-Hueso A, Gamir-Gamir ML, Alonso-Ferreira V, Vázquez-Díaz M, Posada de la Paz M, Ayuso-García C (2012) Fibrodysplasia ossificans progressiva in Spain: epidemiological, clinical, and genetic aspects. Bone 51(4):748–755. doi:10.​1016/​j.​bone.​2012.​07.​002 PubMedCrossRef
54.
go back to reference Dhamangaonkar AC, Tawari AA, Goregaonkar AB (2013) Fibrodysplasia ossificans progressiva: a case report. J Orthop Surg (Hong Kong) 21(3):383–386CrossRef Dhamangaonkar AC, Tawari AA, Goregaonkar AB (2013) Fibrodysplasia ossificans progressiva: a case report. J Orthop Surg (Hong Kong) 21(3):383–386CrossRef
55.
go back to reference Pignolo RJ, Shore EM, Kaplan FS (2013) Fibrodysplasia ossificans progressiva: diagnosis, management, and therapeutic horizons. Pediatr Endocrinol Rev 10(Suppl 2):437–448PubMedPubMedCentral Pignolo RJ, Shore EM, Kaplan FS (2013) Fibrodysplasia ossificans progressiva: diagnosis, management, and therapeutic horizons. Pediatr Endocrinol Rev 10(Suppl 2):437–448PubMedPubMedCentral
56.
go back to reference Kaplan FS, Pignolo RJ, Shore EM (2013) From mysteries to medicines: drug development for fibrodysplasia ossificans progressive. Expert Opin Orphan Drugs 1(8):637–649PubMedPubMedCentralCrossRef Kaplan FS, Pignolo RJ, Shore EM (2013) From mysteries to medicines: drug development for fibrodysplasia ossificans progressive. Expert Opin Orphan Drugs 1(8):637–649PubMedPubMedCentralCrossRef
57.
go back to reference Giacopelli F, Cappato S, Tonachini L, Mura M, Di Lascio S, Fornasari D, Ravazzolo R, Bocciardi R (2013) Identification and characterization of regulatory elements in the promoter of ACVR1, the gene mutated in Fibrodysplasia Ossificans Progressiva. Orphanet J Rare Dis 8:145. doi:10.1186/1750-1172-8-145 PubMedPubMedCentralCrossRef Giacopelli F, Cappato S, Tonachini L, Mura M, Di Lascio S, Fornasari D, Ravazzolo R, Bocciardi R (2013) Identification and characterization of regulatory elements in the promoter of ACVR1, the gene mutated in Fibrodysplasia Ossificans Progressiva. Orphanet J Rare Dis 8:145. doi:10.​1186/​1750-1172-8-145 PubMedPubMedCentralCrossRef
60.
go back to reference Maftei C, Rypens F, Thiffault I, Dubé J, Laberge AM, Lemyre E (2015) Fibrodysplasia ossificans progressiva: bilateral hallux valgus on ultrasound a clue for the first prenatal diagnosis for this condition—clinical report and review of the literature. Prenat Diagn 35(3):305–307. doi:10.1002/pd.4518 PubMedCrossRef Maftei C, Rypens F, Thiffault I, Dubé J, Laberge AM, Lemyre E (2015) Fibrodysplasia ossificans progressiva: bilateral hallux valgus on ultrasound a clue for the first prenatal diagnosis for this condition—clinical report and review of the literature. Prenat Diagn 35(3):305–307. doi:10.​1002/​pd.​4518 PubMedCrossRef
61.
go back to reference Morales-Piga A, Bachiller-Corral J, González-Herranz P, Medrano-SanIldelfonso M, Olmedo-Garzón J, Sánchez-Duffhues G (2015) Osteochondromas in fibrodysplasia ossificans progressiva: a widespread trait with a streaking but overlooked appearance when arising at femoral bone end. Rheumatol Int 35(10):1759–1767. doi:10.1007/s00296-015-3301-6 PubMedCrossRef Morales-Piga A, Bachiller-Corral J, González-Herranz P, Medrano-SanIldelfonso M, Olmedo-Garzón J, Sánchez-Duffhues G (2015) Osteochondromas in fibrodysplasia ossificans progressiva: a widespread trait with a streaking but overlooked appearance when arising at femoral bone end. Rheumatol Int 35(10):1759–1767. doi:10.​1007/​s00296-015-3301-6 PubMedCrossRef
62.
go back to reference Bertamino M, Severino M, Schiaffino MC, Garrè ML, Bocciardi R, Ravazzolo R, Rossi A, Di Rocco M (2015) New insights into central nervous system involvement in FOP: case report and review of the literature. Am J Med Genet A 167A(11):2817–2821. doi:10.1002/ajmg.a.37271 PubMedCrossRef Bertamino M, Severino M, Schiaffino MC, Garrè ML, Bocciardi R, Ravazzolo R, Rossi A, Di Rocco M (2015) New insights into central nervous system involvement in FOP: case report and review of the literature. Am J Med Genet A 167A(11):2817–2821. doi:10.​1002/​ajmg.​a.​37271 PubMedCrossRef
66.
go back to reference Agarwal S, Loder S, Brownley C, Cholok D, Mangiavini L, Li J, Breuler C, Sung HH, Li S, Ranganathan K, Peterson J, Tompkins R, Herndon D, Xiao W, Jumlongras D, Olsen BR, Davis TA, Mishina Y, Schipani E, Levi B (2016) Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification. Proc Natl Acad Sci USA 113(3):E338–E347. doi:10.1073/pnas.1515397113 PubMedCrossRef Agarwal S, Loder S, Brownley C, Cholok D, Mangiavini L, Li J, Breuler C, Sung HH, Li S, Ranganathan K, Peterson J, Tompkins R, Herndon D, Xiao W, Jumlongras D, Olsen BR, Davis TA, Mishina Y, Schipani E, Levi B (2016) Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification. Proc Natl Acad Sci USA 113(3):E338–E347. doi:10.​1073/​pnas.​1515397113 PubMedCrossRef
67.
go back to reference Pignolo RJ, Bedford-Gay C, Liljesthröm M, Durbin-Johnson BP, Shore EM, Rocke DM, Kaplan FS (2016) The natural history of flare-ups in fibrodysplasia ossificans progressiva (FOP): a comprehensive global assessment. J Bone Miner Res 31(3):650–656. doi:10.1002/jbmr.2728 PubMedCrossRef Pignolo RJ, Bedford-Gay C, Liljesthröm M, Durbin-Johnson BP, Shore EM, Rocke DM, Kaplan FS (2016) The natural history of flare-ups in fibrodysplasia ossificans progressiva (FOP): a comprehensive global assessment. J Bone Miner Res 31(3):650–656. doi:10.​1002/​jbmr.​2728 PubMedCrossRef
68.
go back to reference Cappato S, Tonachini L, Giacopelli F, Tirone M, Galietta LJ, Sormani M, Giovenzana A, Spinelli AE, Canciani B, Brunelli S, Ravazzolo R, Bocciardi R (2016) High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva. Dis Model Mech 9(6):685–696. doi:10.1242/dmm.023929 PubMedPubMedCentralCrossRef Cappato S, Tonachini L, Giacopelli F, Tirone M, Galietta LJ, Sormani M, Giovenzana A, Spinelli AE, Canciani B, Brunelli S, Ravazzolo R, Bocciardi R (2016) High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva. Dis Model Mech 9(6):685–696. doi:10.​1242/​dmm.​023929 PubMedPubMedCentralCrossRef
70.
go back to reference Roberts PH (1968) Heterotopic ossification complicating paralysis of intracranial origin. J Bone Joint Surg Am 50:70–77CrossRef Roberts PH (1968) Heterotopic ossification complicating paralysis of intracranial origin. J Bone Joint Surg Am 50:70–77CrossRef
71.
go back to reference Hoffer MM, Garrett A, Brink J, Perry J, Hale W, Nickel VL (1971) The orthopaedic management of brain-injured children. J Bone Joint Surg Am 53(3):567–577PubMedCrossRef Hoffer MM, Garrett A, Brink J, Perry J, Hale W, Nickel VL (1971) The orthopaedic management of brain-injured children. J Bone Joint Surg Am 53(3):567–577PubMedCrossRef
72.
go back to reference Larson JM, Michalski JP, Collacott EA, Eltorai D, McCombs CC, Madorsky JB (1981) Increased prevalence of HLA-B27 in patients with ectopic ossification following traumatic spinal cord injury. Rheumatol Rehabil 20(4):193–197PubMedCrossRef Larson JM, Michalski JP, Collacott EA, Eltorai D, McCombs CC, Madorsky JB (1981) Increased prevalence of HLA-B27 in patients with ectopic ossification following traumatic spinal cord injury. Rheumatol Rehabil 20(4):193–197PubMedCrossRef
73.
go back to reference Mital MA, Garber JE, Stinson JT (1987) Ectopic bone formation in children and adolescents with head injuries: its management. J Pediatr Orthop 7(1):83–90PubMedCrossRef Mital MA, Garber JE, Stinson JT (1987) Ectopic bone formation in children and adolescents with head injuries: its management. J Pediatr Orthop 7(1):83–90PubMedCrossRef
74.
go back to reference Spencer RF (1987) The effect of head injury on fracture healing. A quantitative assessment. J Bone Joint Surg Br 69(4):525–528PubMed Spencer RF (1987) The effect of head injury on fracture healing. A quantitative assessment. J Bone Joint Surg Br 69(4):525–528PubMed
75.
go back to reference Drane WE, Tipler BM (1987) Heterotopic ossification (myositis ossificans) in acquired immune deficiency syndrome. Detection by gallium scintigraphy. Clin Nucl Med 12(6):433–435PubMedCrossRef Drane WE, Tipler BM (1987) Heterotopic ossification (myositis ossificans) in acquired immune deficiency syndrome. Detection by gallium scintigraphy. Clin Nucl Med 12(6):433–435PubMedCrossRef
76.
go back to reference Garland DE, Shimoyama ST, Lugo C, Barras D, Gilgoff I (1989) Spinal cord insults and heterotopic ossification in the pediatric population. Clin Orthop Relat Res 245:303–310 Garland DE, Shimoyama ST, Lugo C, Barras D, Gilgoff I (1989) Spinal cord insults and heterotopic ossification in the pediatric population. Clin Orthop Relat Res 245:303–310
77.
go back to reference Hurvitz EA, Mandac BR, Davidoff G, Johnson JH, Nelson VS (1992) Risk factors for heterotopic ossification in children and adolescents with severe traumatic brain injury. Arch Phys Med Rehabil 73(5):459–462PubMed Hurvitz EA, Mandac BR, Davidoff G, Johnson JH, Nelson VS (1992) Risk factors for heterotopic ossification in children and adolescents with severe traumatic brain injury. Arch Phys Med Rehabil 73(5):459–462PubMed
78.
go back to reference Heindl UT, Laub MC (1996) Outcome of persistent vegetative state following hypoxic or traumatic brain injury in children and adolescents. Neuropediatrics 27(2):94–100PubMedCrossRef Heindl UT, Laub MC (1996) Outcome of persistent vegetative state following hypoxic or traumatic brain injury in children and adolescents. Neuropediatrics 27(2):94–100PubMedCrossRef
79.
go back to reference Hung JC, Appleton RE, Abernethy L (1997) Myositis ossificans complicating severe Guillain–Barré syndrome. Dev Med Child Neurol 39(11):775–776PubMedCrossRef Hung JC, Appleton RE, Abernethy L (1997) Myositis ossificans complicating severe Guillain–Barré syndrome. Dev Med Child Neurol 39(11):775–776PubMedCrossRef
80.
go back to reference Freebourn TM, Barber DB, Able AC (1999) The treatment of immature heterotopic ossification in spinal cord injury with combination surgery, radiation therapy and NSAID. Spinal Cord 37(1):50–53PubMedCrossRef Freebourn TM, Barber DB, Able AC (1999) The treatment of immature heterotopic ossification in spinal cord injury with combination surgery, radiation therapy and NSAID. Spinal Cord 37(1):50–53PubMedCrossRef
81.
go back to reference Kluger G, Kochs A, Holthausen H (2000) Heterotopic ossification in childhood and adolescence. J Child Neurol 15(6):406–413PubMedCrossRef Kluger G, Kochs A, Holthausen H (2000) Heterotopic ossification in childhood and adolescence. J Child Neurol 15(6):406–413PubMedCrossRef
82.
go back to reference van Kuijk AA, Geurts AC, van Kuppevelt HJ (2002) Neurogenic heterotopic ossification in spinal cord injury. Spinal Cord 40(7):313–326PubMedCrossRef van Kuijk AA, Geurts AC, van Kuppevelt HJ (2002) Neurogenic heterotopic ossification in spinal cord injury. Spinal Cord 40(7):313–326PubMedCrossRef
83.
go back to reference Zidek K, Srinivasan R (2003) Rehabilitation of a child with a spinal cord injury. Semin Pediatr Neurol 10(2):140–150PubMedCrossRef Zidek K, Srinivasan R (2003) Rehabilitation of a child with a spinal cord injury. Semin Pediatr Neurol 10(2):140–150PubMedCrossRef
84.
go back to reference Chauveau C, Devedjian JC, Blary MC, Delecourt C, Hardouin P, Jeanfils J, Broux O (2004) Gene expression in human osteoblastic cells from normal and heterotopic ossification. Exp Mol Pathol 76(1):37–43PubMedCrossRef Chauveau C, Devedjian JC, Blary MC, Delecourt C, Hardouin P, Jeanfils J, Broux O (2004) Gene expression in human osteoblastic cells from normal and heterotopic ossification. Exp Mol Pathol 76(1):37–43PubMedCrossRef
85.
go back to reference Banovac K, Sherman AL, Estores IM, Banovac F (2004) Prevention and treatment of heterotopic ossification after spinal cord injury. J Spinal Cord Med 27(4):376–382PubMedCrossRef Banovac K, Sherman AL, Estores IM, Banovac F (2004) Prevention and treatment of heterotopic ossification after spinal cord injury. J Spinal Cord Med 27(4):376–382PubMedCrossRef
86.
go back to reference Estrores IM, Harrington A, Banovac K (2004) C-reactive protein and erythrocyte sedimentation rate in patients with heterotopic ossification after spinal cord injury. J Spinal Cord Med 27(5):434–437PubMedCrossRef Estrores IM, Harrington A, Banovac K (2004) C-reactive protein and erythrocyte sedimentation rate in patients with heterotopic ossification after spinal cord injury. J Spinal Cord Med 27(5):434–437PubMedCrossRef
87.
go back to reference Schmidt OI, Heyde CE, Ertel W, Stahel PF (2005) Closed head injury—an inflammatory disease? Brain Res Brain Res Rev 48(2):388–399PubMedCrossRef Schmidt OI, Heyde CE, Ertel W, Stahel PF (2005) Closed head injury—an inflammatory disease? Brain Res Brain Res Rev 48(2):388–399PubMedCrossRef
88.
go back to reference Lerner UH (2006) Deletions of genes encoding calcitonin/alpha-CGRP, amylin and calcitonin receptor have given new and unexpected insights into the function of calcitonin receptors and calcitonin receptor-like receptors in bone. J Musculoskelet Neuronal Interact 6(1):87–95PubMed Lerner UH (2006) Deletions of genes encoding calcitonin/alpha-CGRP, amylin and calcitonin receptor have given new and unexpected insights into the function of calcitonin receptors and calcitonin receptor-like receptors in bone. J Musculoskelet Neuronal Interact 6(1):87–95PubMed
89.
go back to reference Balboni TA, Gobezie R, Mamon HJ (2006) Heterotopic ossification: pathophysiology, clinical features, and the role of radiotherapy for prophylaxis. Int J Radiat Oncol Biol Phys 65(5):1289–1299PubMedCrossRef Balboni TA, Gobezie R, Mamon HJ (2006) Heterotopic ossification: pathophysiology, clinical features, and the role of radiotherapy for prophylaxis. Int J Radiat Oncol Biol Phys 65(5):1289–1299PubMedCrossRef
90.
go back to reference Wang F, Li Y, Zhu X (2006) Relationship between the central nervous system injury and the heterotopic ossification. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 20(8):854–857PubMed Wang F, Li Y, Zhu X (2006) Relationship between the central nervous system injury and the heterotopic ossification. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 20(8):854–857PubMed
91.
go back to reference da Paz AC, Carod Artal FJ, Kalil RK (2007) The function of proprioceptors in bone organization: a possible explanation for neurogenic heterotopic ossification in patients with neurological damage. Med Hypotheses 68(1):67–73PubMedCrossRef da Paz AC, Carod Artal FJ, Kalil RK (2007) The function of proprioceptors in bone organization: a possible explanation for neurogenic heterotopic ossification in patients with neurological damage. Med Hypotheses 68(1):67–73PubMedCrossRef
92.
go back to reference Lerner UH, Persson E (2008) Osteotropic effects by the neuropeptides calcitonin gene-related peptide, substance P and vasoactive intestinal peptide. J Musculoskelet Neuronal Interact 8(2):154–165PubMed Lerner UH, Persson E (2008) Osteotropic effects by the neuropeptides calcitonin gene-related peptide, substance P and vasoactive intestinal peptide. J Musculoskelet Neuronal Interact 8(2):154–165PubMed
95.
96.
go back to reference Cipriano CA, Pill SG, Keenan MA (2009) Heterotopic ossification following traumatic brain injury and spinal cord injury. J Am Acad Orthop Surg 17(11):689–697PubMedCrossRef Cipriano CA, Pill SG, Keenan MA (2009) Heterotopic ossification following traumatic brain injury and spinal cord injury. J Am Acad Orthop Surg 17(11):689–697PubMedCrossRef
97.
go back to reference Suzuki A, Uemura T, Nakamura H (2010) Control of bone remodeling by nervous system. Neural involvement in fracture healing and bone regeneration. Clin Calcium 20(12):1820–1827. doi:CliCa101218201827PubMed Suzuki A, Uemura T, Nakamura H (2010) Control of bone remodeling by nervous system. Neural involvement in fracture healing and bone regeneration. Clin Calcium 20(12):1820–1827. doi:CliCa101218201827PubMed
98.
go back to reference Togari A (2010) Control of bone remodeling by nervous system. Regulation of bone metabolism by peripheral nervous system. Clin Calcium 20(12):1831–1838. doi:CliCa101218311838PubMed Togari A (2010) Control of bone remodeling by nervous system. Regulation of bone metabolism by peripheral nervous system. Clin Calcium 20(12):1831–1838. doi:CliCa101218311838PubMed
101.
go back to reference Sakellariou VI, Grigoriou E, Mavrogenis AF, Soucacos PN, Papagelopoulos PJ (2012) Heterotopic ossification following traumatic brain injury and spinal cord injury: insight into the etiology and pathophysiology. J Musculoskelet Neuronal Interact 12(4):230–240PubMed Sakellariou VI, Grigoriou E, Mavrogenis AF, Soucacos PN, Papagelopoulos PJ (2012) Heterotopic ossification following traumatic brain injury and spinal cord injury: insight into the etiology and pathophysiology. J Musculoskelet Neuronal Interact 12(4):230–240PubMed
104.
go back to reference Paterson DC (1970) Myositis ossificans circumscripta. Report of four cases without history of injury. J Bone Joint Surg Br 52(2):296–301PubMed Paterson DC (1970) Myositis ossificans circumscripta. Report of four cases without history of injury. J Bone Joint Surg Br 52(2):296–301PubMed
105.
go back to reference Munster AM, Bruck HM, Johns LA, Von Prince K, Kirkman EM, Remig RL (1972) Heterotopic calcification following burns: a prospective study. J Trauma 12(12):1071–1074PubMedCrossRef Munster AM, Bruck HM, Johns LA, Von Prince K, Kirkman EM, Remig RL (1972) Heterotopic calcification following burns: a prospective study. J Trauma 12(12):1071–1074PubMedCrossRef
106.
go back to reference Jackson DW, Feagin JA (1973) Quadriceps contusions in young athletes. Relation of severity of injury to treatment and prognosis. J Bone Joint Surg Am 55(1):95–105PubMedCrossRef Jackson DW, Feagin JA (1973) Quadriceps contusions in young athletes. Relation of severity of injury to treatment and prognosis. J Bone Joint Surg Am 55(1):95–105PubMedCrossRef
107.
go back to reference Suzuki Y, Hisada K, Takeda M (1974) Demonstration of myositis ossificans by 99 mTc pyrophosphate bone scanning. Radiology 111(3):663–664PubMedCrossRef Suzuki Y, Hisada K, Takeda M (1974) Demonstration of myositis ossificans by 99 mTc pyrophosphate bone scanning. Radiology 111(3):663–664PubMedCrossRef
108.
go back to reference Goldman AB (1976) Myositis ossificans circumscripta: a benign lesion with a malignant differential diagnosis. AJR Am J Roentgenol 126(1):32–40PubMedCrossRef Goldman AB (1976) Myositis ossificans circumscripta: a benign lesion with a malignant differential diagnosis. AJR Am J Roentgenol 126(1):32–40PubMedCrossRef
109.
go back to reference Ogilvie-Harris DJ, Fornasier VL (1980) Pseudomalignant myositis ossificans: heterotopic new-bone formation without a history of trauma. J Bone Joint Surg Am 62(8):1274–1283PubMedCrossRef Ogilvie-Harris DJ, Fornasier VL (1980) Pseudomalignant myositis ossificans: heterotopic new-bone formation without a history of trauma. J Bone Joint Surg Am 62(8):1274–1283PubMedCrossRef
110.
go back to reference Eckardt JJ, Ivins JC, Perry HO, Unni KK (1981) Osteosarcoma arising in heterotopic ossification of dermatomyositis: case report and review of the literature. Cancer 48(5):1256–1261PubMedCrossRef Eckardt JJ, Ivins JC, Perry HO, Unni KK (1981) Osteosarcoma arising in heterotopic ossification of dermatomyositis: case report and review of the literature. Cancer 48(5):1256–1261PubMedCrossRef
111.
go back to reference Ben-Youssef L, Schmidt TL (1983) Battered child syndrome simulating myositis. J Pediatr Orthop 3(3):392–395PubMedCrossRef Ben-Youssef L, Schmidt TL (1983) Battered child syndrome simulating myositis. J Pediatr Orthop 3(3):392–395PubMedCrossRef
112.
go back to reference Amendola MA, Glazer GM, Agha FP, Francis IR, Weatherbee L, Martel W (1983) Myositis ossificans circumscripta: computed tomographic diagnosis. Radiology 149(3):775–779PubMedCrossRef Amendola MA, Glazer GM, Agha FP, Francis IR, Weatherbee L, Martel W (1983) Myositis ossificans circumscripta: computed tomographic diagnosis. Radiology 149(3):775–779PubMedCrossRef
113.
go back to reference Carlson WO, Klassen RA (1984) Myositis ossificans of the upper extremity: a long-term follow-up. J Pediatr Orthop 4(6):693–696PubMedCrossRef Carlson WO, Klassen RA (1984) Myositis ossificans of the upper extremity: a long-term follow-up. J Pediatr Orthop 4(6):693–696PubMedCrossRef
114.
go back to reference Merkow SJ, St Clair HS, Goldberg MJ (1985) Myositis ossificans masquerading as sepsis. J Pediatr Orthop 5(5):601–604PubMedCrossRef Merkow SJ, St Clair HS, Goldberg MJ (1985) Myositis ossificans masquerading as sepsis. J Pediatr Orthop 5(5):601–604PubMedCrossRef
115.
go back to reference Pazzaglia UE, Beluffi G, Colombo A, Marchi A, Coci A, Ceciliani L (1986) Myositis ossificans in the newborn. A case report. J Bone Joint Surg Am 68(3):456–458PubMedCrossRef Pazzaglia UE, Beluffi G, Colombo A, Marchi A, Coci A, Ceciliani L (1986) Myositis ossificans in the newborn. A case report. J Bone Joint Surg Am 68(3):456–458PubMedCrossRef
116.
go back to reference Peck RJ, Metreweli C (1988) Early myositis ossificans: a new echographic sign. Clin Radiol 39(6):586–588PubMedCrossRef Peck RJ, Metreweli C (1988) Early myositis ossificans: a new echographic sign. Clin Radiol 39(6):586–588PubMedCrossRef
117.
go back to reference Booth DW, Westers BM (1989) The management of athletes with myositis ossificans traumatica. Can J Sport Sci 14(1):10–16PubMed Booth DW, Westers BM (1989) The management of athletes with myositis ossificans traumatica. Can J Sport Sci 14(1):10–16PubMed
118.
go back to reference Spencer JD, Missen GA (1989) Pseudomalignant heterotopic ossification (“myositis ossificans”). Recurrence after excision with subsequent resorption. J Bone Joint Surg Br 71(2):317–319PubMed Spencer JD, Missen GA (1989) Pseudomalignant heterotopic ossification (“myositis ossificans”). Recurrence after excision with subsequent resorption. J Bone Joint Surg Br 71(2):317–319PubMed
119.
go back to reference Heinrich SD, Zembo MM, MacEwen GD (1989) Pseudomalignant myositis ossificans. Orthopedics 12(4):599–602PubMed Heinrich SD, Zembo MM, MacEwen GD (1989) Pseudomalignant myositis ossificans. Orthopedics 12(4):599–602PubMed
120.
go back to reference Schütte HE, van der Heul RO (1990) Pseudomalignant, nonneoplastic osseous soft-tissue tumors of the hand and foot. Radiology 176(1):149–153PubMedCrossRef Schütte HE, van der Heul RO (1990) Pseudomalignant, nonneoplastic osseous soft-tissue tumors of the hand and foot. Radiology 176(1):149–153PubMedCrossRef
121.
go back to reference Evans EB (1991) Heterotopic bone formation in thermal burns. Clin Orthop Relat Res 263:94–101 Evans EB (1991) Heterotopic bone formation in thermal burns. Clin Orthop Relat Res 263:94–101
122.
go back to reference Heifetz SA, Galliani CA, DeRosa GP (1992) Myositis (fasciitis) ossificans in an infant. Pediatr Pathol 12(2):223–229PubMedCrossRef Heifetz SA, Galliani CA, DeRosa GP (1992) Myositis (fasciitis) ossificans in an infant. Pediatr Pathol 12(2):223–229PubMedCrossRef
123.
go back to reference Koch BM, Wu CM, Randolph J, Eng GD (1992) Heterotopic ossification in children with burns: two case reports. Arch Phys Med Rehabil 73(11):1104–1106PubMed Koch BM, Wu CM, Randolph J, Eng GD (1992) Heterotopic ossification in children with burns: two case reports. Arch Phys Med Rehabil 73(11):1104–1106PubMed
124.
go back to reference Bronfen C, Touzet P, Peuchmaur M, Prieur AM, Rigault P (1993) Non-traumatic myositis ossificans in a child. Review of the literature apropos of a case mimicking malignant tumor. Rev Chir Orthop Reparatrice Appar Mot 79(3):229–234PubMed Bronfen C, Touzet P, Peuchmaur M, Prieur AM, Rigault P (1993) Non-traumatic myositis ossificans in a child. Review of the literature apropos of a case mimicking malignant tumor. Rev Chir Orthop Reparatrice Appar Mot 79(3):229–234PubMed
125.
go back to reference Bos CF, Eulderink F, Bloem JL (1993) Bilateral pelvitrochanteric heterotopic ossification in a child. A case report. J Bone Joint Surg Am 75(12):1840–1843PubMedCrossRef Bos CF, Eulderink F, Bloem JL (1993) Bilateral pelvitrochanteric heterotopic ossification in a child. A case report. J Bone Joint Surg Am 75(12):1840–1843PubMedCrossRef
126.
go back to reference Cushner FD, Morwessel RM (1995) Myositis ossificans in children. Orthopedics 18(3):287–291PubMed Cushner FD, Morwessel RM (1995) Myositis ossificans in children. Orthopedics 18(3):287–291PubMed
127.
go back to reference Nisolle JF, Delaunois L, Trigaux JP (1996) Myositis ossificans of the chest wall. Eur Respir J 9(1):178–179PubMedCrossRef Nisolle JF, Delaunois L, Trigaux JP (1996) Myositis ossificans of the chest wall. Eur Respir J 9(1):178–179PubMedCrossRef
128.
go back to reference Adderson EE, Bohnsack JF (1996) Traumatic myositis ossificans simulating soft tissue infection. Pediatr Infect Dis J 15(6):551–553PubMedCrossRef Adderson EE, Bohnsack JF (1996) Traumatic myositis ossificans simulating soft tissue infection. Pediatr Infect Dis J 15(6):551–553PubMedCrossRef
129.
go back to reference Jouve JL, Cottalorda J, Bollini G, Scheiner C, Daoud A (1997) Myositis ossificans: report of seven cases in children. J Pediatr Orthop B 6(1):33–41PubMedCrossRef Jouve JL, Cottalorda J, Bollini G, Scheiner C, Daoud A (1997) Myositis ossificans: report of seven cases in children. J Pediatr Orthop B 6(1):33–41PubMedCrossRef
130.
go back to reference Howard CB, Porat S, Bar-On E, Nyska M, Segal D (1998) Traumatic myositis ossificans of the quadriceps in infants. J Pediatr Orthop B 7(1):80–82PubMedCrossRef Howard CB, Porat S, Bar-On E, Nyska M, Segal D (1998) Traumatic myositis ossificans of the quadriceps in infants. J Pediatr Orthop B 7(1):80–82PubMedCrossRef
131.
go back to reference Traoré O, Yilboudo J, Cissé R, Compaoré TM, Bandré E, Ouiminga RM (1998) Non-traumatic circumscribed myositis ossificans. Apropos of a bilateral localization. Rev Chir Orthop Reparatrice Appar Mot 84(1):79–83PubMed Traoré O, Yilboudo J, Cissé R, Compaoré TM, Bandré E, Ouiminga RM (1998) Non-traumatic circumscribed myositis ossificans. Apropos of a bilateral localization. Rev Chir Orthop Reparatrice Appar Mot 84(1):79–83PubMed
132.
go back to reference Akgün I, Erdoğan F, Aydingöz O, Kesmezacar H (1998) Myositis ossificans in early childhood. Arthroscopy 14(5):522–526PubMedCrossRef Akgün I, Erdoğan F, Aydingöz O, Kesmezacar H (1998) Myositis ossificans in early childhood. Arthroscopy 14(5):522–526PubMedCrossRef
133.
go back to reference Kusuma S, Lourie GM, Lins RE (1999) Myositis ossificans of the hand. J Hand Surg Br 24(1):128–130PubMedCrossRef Kusuma S, Lourie GM, Lins RE (1999) Myositis ossificans of the hand. J Hand Surg Br 24(1):128–130PubMedCrossRef
134.
go back to reference Turra CS, Gigante C, Perini L, D’Amore ES (1999) Pseudomalignant myositis ossificans in children. Description of a case and review of the literature. Chir Organi Mov 84(1):93–100PubMed Turra CS, Gigante C, Perini L, D’Amore ES (1999) Pseudomalignant myositis ossificans in children. Description of a case and review of the literature. Chir Organi Mov 84(1):93–100PubMed
135.
go back to reference Gindele A, Schwamborn D, Tsironis K, Benz-Bohm G (2000) Myositis ossificans traumatica in young children: report of three cases and review of the literature. Pediatr Radiol 30(7):451–459PubMedCrossRef Gindele A, Schwamborn D, Tsironis K, Benz-Bohm G (2000) Myositis ossificans traumatica in young children: report of three cases and review of the literature. Pediatr Radiol 30(7):451–459PubMedCrossRef
136.
137.
go back to reference Kaleli T, Temiz A, Oztürk H (2003) Pseudomalignant myositis ossificans of the wrist causing compression of the ulnar nerve and artery. A case report. Acta Orthop Belg 69(3):289–291PubMed Kaleli T, Temiz A, Oztürk H (2003) Pseudomalignant myositis ossificans of the wrist causing compression of the ulnar nerve and artery. A case report. Acta Orthop Belg 69(3):289–291PubMed
138.
go back to reference Messina M, Volterrani L, Molinaro F, Nardi N, Amato G (2006) Myositis ossificans in children: description of a clinical case with a rare localization. Minerva Pediatr 58(1):69–72PubMed Messina M, Volterrani L, Molinaro F, Nardi N, Amato G (2006) Myositis ossificans in children: description of a clinical case with a rare localization. Minerva Pediatr 58(1):69–72PubMed
139.
go back to reference Inan M, Chan G, Dabney K, Miller F (2006) Heterotopic ossification following hip osteotomies in cerebral palsy: incidence and risk factors. J Pediatr Orthop 26(4):551–556PubMedCrossRef Inan M, Chan G, Dabney K, Miller F (2006) Heterotopic ossification following hip osteotomies in cerebral palsy: incidence and risk factors. J Pediatr Orthop 26(4):551–556PubMedCrossRef
140.
go back to reference Khoury J, Jerushalmi J, Loberant N (2006) Tc-99m MIBI/Tc-99m MDP mismatch: a useful scintigraphic finding in differentiating myositis ossificans from malignant tumor of soft tissue. Clin Nucl Med 31(9):547–549PubMedCrossRef Khoury J, Jerushalmi J, Loberant N (2006) Tc-99m MIBI/Tc-99m MDP mismatch: a useful scintigraphic finding in differentiating myositis ossificans from malignant tumor of soft tissue. Clin Nucl Med 31(9):547–549PubMedCrossRef
142.
go back to reference Cabello García D, Rodríguez Fernández A, Gómez Río M, Moreno MJ, Rebollo Aguirre AC, Martín Castro A, Llamas Elvira JM (2008) Circumscript myositis ossificans in a 4-year-old boy. Rev Esp Med Nucl 27(5):358–362PubMedCrossRef Cabello García D, Rodríguez Fernández A, Gómez Río M, Moreno MJ, Rebollo Aguirre AC, Martín Castro A, Llamas Elvira JM (2008) Circumscript myositis ossificans in a 4-year-old boy. Rev Esp Med Nucl 27(5):358–362PubMedCrossRef
143.
go back to reference Melamed E, Angel D (2008) Myositis ossificans mimicking compartment syndrome of the forearm. Orthopedics 31(12):pii: orthosupersite.com/view.asp?Rid = 32936 Melamed E, Angel D (2008) Myositis ossificans mimicking compartment syndrome of the forearm. Orthopedics 31(12):pii: orthosupersite.com/view.asp?Rid = 32936
144.
go back to reference Tsailas PG, Babis GC, Nikolopoulos K, Soucacos PN, Korres DS (2009) The effectiveness of two COX-2 inhibitors in the prophylaxis against heterotopic new bone formation: an experimental study in rabbits. J Surg Res 151(1):108–114. doi:10.1016/j.jss.2007.12.804 PubMedCrossRef Tsailas PG, Babis GC, Nikolopoulos K, Soucacos PN, Korres DS (2009) The effectiveness of two COX-2 inhibitors in the prophylaxis against heterotopic new bone formation: an experimental study in rabbits. J Surg Res 151(1):108–114. doi:10.​1016/​j.​jss.​2007.​12.​804 PubMedCrossRef
147.
go back to reference Mania VM, Kallivokas AG, Malavaki C, Asimakopoulou AP, Kanakis J, Theocharis AD, Klironomos G, Gatzounis G, Mouzaki A, Panagiotopoulos E, Karamanos NK (2009) A comparative biochemical analysis of glycosaminoglycans and proteoglycans in human orthotopic and heterotopic bone. IUBMB Life 61(4):447–452. doi:10.1002/iub.167 PubMedCrossRef Mania VM, Kallivokas AG, Malavaki C, Asimakopoulou AP, Kanakis J, Theocharis AD, Klironomos G, Gatzounis G, Mouzaki A, Panagiotopoulos E, Karamanos NK (2009) A comparative biochemical analysis of glycosaminoglycans and proteoglycans in human orthotopic and heterotopic bone. IUBMB Life 61(4):447–452. doi:10.​1002/​iub.​167 PubMedCrossRef
148.
152.
go back to reference Susnjar T, Biocić M, Pogorelić Z (2010) Traumatic heterotopic ossification of the elbow in children—a case report. Acta Chir Belg 110(2):246–249PubMedCrossRef Susnjar T, Biocić M, Pogorelić Z (2010) Traumatic heterotopic ossification of the elbow in children—a case report. Acta Chir Belg 110(2):246–249PubMedCrossRef
157.
160.
go back to reference Muñoz-Mahamud E, Poggio D, Combalia A (2011) Myositis ossificans mimicking parosteal osteosarcoma: a case report and literature review. Acta Orthop Belg 77(2):274–279PubMed Muñoz-Mahamud E, Poggio D, Combalia A (2011) Myositis ossificans mimicking parosteal osteosarcoma: a case report and literature review. Acta Orthop Belg 77(2):274–279PubMed
161.
163.
go back to reference Pathak AC, Patil AK, Sheth B, Bansal R (2012) Pseudo-acetabulum due to heterotopic ossification in a child with post-traumatic neglected posterior hip dislocation. J Orthop Case Rep 2(4):14–18PubMedPubMedCentral Pathak AC, Patil AK, Sheth B, Bansal R (2012) Pseudo-acetabulum due to heterotopic ossification in a child with post-traumatic neglected posterior hip dislocation. J Orthop Case Rep 2(4):14–18PubMedPubMedCentral
165.
go back to reference Naranje S, Kancherla R, Kannan A, Malhotra R, Sharma L, Sankineani SR (2012) Extraarticular bony ankylosis in a child with supracondylar fracture of humerus. Chin J Traumatol 15(5):300–302PubMed Naranje S, Kancherla R, Kannan A, Malhotra R, Sharma L, Sankineani SR (2012) Extraarticular bony ankylosis in a child with supracondylar fracture of humerus. Chin J Traumatol 15(5):300–302PubMed
171.
174.
go back to reference Yamaga K, Kobayashi E, Kubota D, Setsu N, Tanaka Y, Minami Y, Tanzawa Y, Nakatani F, Kawai A, Chuman H (2015) Pediatric myositis ossificans mimicking osteosarcoma. Pediatr Int 57(5):996–999. doi:10.1111/ped.12672 PubMedCrossRef Yamaga K, Kobayashi E, Kubota D, Setsu N, Tanaka Y, Minami Y, Tanzawa Y, Nakatani F, Kawai A, Chuman H (2015) Pediatric myositis ossificans mimicking osteosarcoma. Pediatr Int 57(5):996–999. doi:10.​1111/​ped.​12672 PubMedCrossRef
178.
180.
go back to reference Agarwal S, Loder S, Cholok D, Li J, Breuler C, Drake J, Brownley C, Peterson J, Li S, Levi B (2016) Surgical excision of heterotopic ossification leads to re-emergence of mesenchymal stem cell populations responsible for recurrence. Stem Cells Transl Med pii:sctm.2015-0365. [Epub ahead of print] Agarwal S, Loder S, Cholok D, Li J, Breuler C, Drake J, Brownley C, Peterson J, Li S, Levi B (2016) Surgical excision of heterotopic ossification leads to re-emergence of mesenchymal stem cell populations responsible for recurrence. Stem Cells Transl Med pii:sctm.2015-0365. [Epub ahead of print]
Metadata
Title
Myositis ossificans in children: a review
Authors
N. K. Sferopoulos
R. Kotakidou
A. S. Petropoulos
Publication date
01-05-2017
Publisher
Springer Paris
Published in
European Journal of Orthopaedic Surgery & Traumatology / Issue 4/2017
Print ISSN: 1633-8065
Electronic ISSN: 1432-1068
DOI
https://doi.org/10.1007/s00590-017-1932-x

Other articles of this Issue 4/2017

European Journal of Orthopaedic Surgery & Traumatology 4/2017 Go to the issue