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European Journal of Orthopaedic Surgery & Traumatology

Published in:

01-05-2009 | Original Article

The effect of 6 months oral alendronate treatment on periprosthetic bone loss after total knee arthroplasty

Authors: Rashid Barakat Abu-Rajab, W. S. Watson, P. Gallacher, B. Walker, R. M. D. Meek

Published in: European Journal of Orthopaedic Surgery & Traumatology | Issue 4/2009

Abstract

Objective

This study was designed to test whether established post-total knee arthroplasty (TKA) bone loss at over 2 years post-surgery could be improved by 6 months of alendronate administration.

Materials and methods

This was a double blind randomized controlled trial. From a previous study assessing periprosthetic bone mineral density (BMD) at 2 years post-surgery, 11 patients were randomised to receive either 70 mg of alendronate per week or a placebo, for 6 months. DXA scans were performed on both knees (operated knee and contralateral knee) at 6 months and compared with pre-treatment DXA scans.

Results

No significant change in BMD following a 6-month administration of alendronate, given 2 years post-TKA was seen. Additionally, alendronate had no effect on Oxford Knee Scores.

Conclusions

The administration of a 6-month course of alendronate has no significant effect on established periprosthetic BMD loss.

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Title: The effect of 6 months oral alendronate treatment on periprosthetic bone loss after total knee arthroplasty
Authors: Rashid Barakat Abu-Rajab
W. S. Watson
P. Gallacher
B. Walker
R. M. D. Meek
Publication date: 01-05-2009
Publisher: Springer-Verlag
Published in: European Journal of Orthopaedic Surgery & Traumatology / Issue 4/2009
Print ISSN: 1633-8065
Electronic ISSN: 1432-1068
DOI: https://doi.org/10.1007/s00590-008-0412-8

At a glance: The STEP trials

Springer Medicine

The effect of 6 months oral alendronate treatment on periprosthetic bone loss after total knee arthroplasty

Abstract

Objective

Materials and methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusions

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