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European Spine Journal

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01-07-2018 | Case Report

Skeletal dissemination in Paget’s disease of the spine

Authors: Tim Rolvien, Sebastian Butscheidt, Jozef Zustin, Michael Amling

Published in: European Spine Journal | Special Issue 3/2018

Abstract

Purpose

Paget’s disease of bone (PDB) is a common skeletal disorder that is associated with locally increased bone turnover, skeletal deformity and pain. We report a case of skeletal dissemination in PDB of the spine.

Methods

Case report.

Results

A 46-year-old former professional athlete suffered from disseminated PDB throughout the spine and hips after various surgical interventions including spondylodesis, bone grafting and bone morphogenetic protein (rhBMP-2) administration. Only intravenous zoledronic acid prevented the further progression of skeletal dissemination, which was expressed by a normalization of (bone-specific) alkaline phosphatase levels. The biopsy obtained from the lumbar spine confirmed the diagnosis of PDB in the absence of malignant transformation.

Conclusions

We outline skeletal dissemination as a possibly surgery-related complication in a patient with PDB in the lumbar spine. Bisphosphonates remain the treatment of first choice in PDB and surgical interventions should be considered very carefully.

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Title: Skeletal dissemination in Paget’s disease of the spine
Authors: Tim Rolvien
Sebastian Butscheidt
Jozef Zustin
Michael Amling
Publication date: 01-07-2018
Publisher: Springer Berlin Heidelberg
Published in: European Spine Journal / Issue Special Issue 3/2018
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-018-5477-4

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Skeletal dissemination in Paget’s disease of the spine

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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