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European Spine Journal

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Open Access 01-07-2014 | Original Article

The pathological changes in the spinal cord after dural tear with and without autologous fascia repair

Authors: Yi Song, Shao Li, Bo Song, Yanli Zhang, Wenting Gao, Ning Li, Kai Fan, Jianmei Ma

Published in: European Spine Journal | Issue 7/2014

Abstract

Purpose

Dural tear is one of the common complications of spinal surgery leading to cerebrospinal fluid leakage followed by serial secondary symptoms. However, little is known about pathological changes of the spinal cord after dural tear. In the present study, we aimed to study the pathological changes in the spinal cord after dural tear with and without autologous fascia repair.

Methods

Sixty Sprague–Dawley rats were used for dural tear and autologous fascia graft repair models. Three days and 1 week after surgery, the pathological changes in the spinal cord were analyzed by immunohistochemistry, Western blot, enzyme-linked immunosorbent assay and spinal somatosensory evoked potentials test.

Results

Neuroinflammation was found in the parenchyma of the spinal cord characterized by gliosis, increased expression of inflammatory factors and infiltration of exogenesis immunocells in the rats without repair, which impaired the sensory conduction function of the spinal cord at the early stage of injury. Repairing with autologous fascia could attenuate neuroinflammation and help to maintain normal sensory conduction function of the spinal cord.

Conclusion

Dural tear could cause a series of inflammatory reactions in the spinal cord and further impair its sensory conduction function at the early stage of injury. Repairing with autologous fascia was a necessary and effective way to prevent the neuroinflammation and to maintain the normal function of the spinal cord.

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Title: The pathological changes in the spinal cord after dural tear with and without autologous fascia repair
Authors: Yi Song
Shao Li
Bo Song
Yanli Zhang
Wenting Gao
Ning Li
Kai Fan
Jianmei Ma
Publication date: 01-07-2014
Publisher: Springer Berlin Heidelberg
Published in: European Spine Journal / Issue 7/2014
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-014-3326-7

At a glance: The STEP trials

Springer Medicine

The pathological changes in the spinal cord after dural tear with and without autologous fascia repair

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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