Skip to main content
Top
Published in: European Spine Journal 9/2009

01-09-2009 | Review Article

Management of pulmonary cement embolism after percutaneous vertebroplasty and kyphoplasty: a systematic review of the literature

Authors: Antonio Krueger, Christopher Bliemel, Ralph Zettl, Steffen Ruchholtz

Published in: European Spine Journal | Issue 9/2009

Login to get access

Abstract

Balloon kyphoplasty and percutaneous vertebroplasty are relatively recent procedures in the treatment of painful vertebral fractures. There are, however, still some uncertainties about the incidence and treatment strategies of pulmonary cement embolisms (PCE). In order to work out a treatment strategy for the management of this complication, we performed a review of the literature. The results show that there is no clear diagnostic or treatment standard for PCE. The literature research revealed that the risk of a pulmonary embolism ranges from 3.5 to 23% for osteoporotic fractures. In cases of asymptomatic patients with peripheral PCE we recommend no treatment besides clinical follow-up; in cases of symptomatic or central embolisms, however, we recommend to proceed according to the guidelines regarding the treatment of thrombotic pulmonary embolisms, which includes initial heparinization and a following 6-month coumarin therapy. In order to avoid any types of embolisms, both procedures should only be performed by experienced surgeons after critical determination of the indications.
Literature
2.
3.
go back to reference Anselmetti GC, Corgnier A, Debernardi F, Regge D (2005) Treatment of painful compression vertebral fractures with vertebroplasty: results and complications. Radiol Med (Torino) 110:262–272 Anselmetti GC, Corgnier A, Debernardi F, Regge D (2005) Treatment of painful compression vertebral fractures with vertebroplasty: results and complications. Radiol Med (Torino) 110:262–272
4.
go back to reference Anselmetti GC, Zoarski G, Manca A et al (2008) Percutaneous vertebroplasty and bone cement leakage: clinical experience with a new high-viscosity bone cement and delivery system for vertebral augmentation in benign and malignant compression fractures. Cardiovasc Intervent Radiol Anselmetti GC, Zoarski G, Manca A et al (2008) Percutaneous vertebroplasty and bone cement leakage: clinical experience with a new high-viscosity bone cement and delivery system for vertebral augmentation in benign and malignant compression fractures. Cardiovasc Intervent Radiol
8.
go back to reference Baumann A, Tauss J, Baumann G, Tomka M, Hessinger M, Tiesenhausen K (2005) Cement embolization into the vena cava and pulmonal arteries after vertebroplasty: interdisciplinary management. Eur J Vasc Endovasc Surg 31:558–561PubMedCrossRef Baumann A, Tauss J, Baumann G, Tomka M, Hessinger M, Tiesenhausen K (2005) Cement embolization into the vena cava and pulmonal arteries after vertebroplasty: interdisciplinary management. Eur J Vasc Endovasc Surg 31:558–561PubMedCrossRef
10.
go back to reference Boger A, Heini P, Windolf M, Schneider E (2007) Adjacent vertebral failure after vertebroplasty: a biomechanical study of low-modulus PMMA cement. Eur Spine J 16:2118–2125PubMedCrossRef Boger A, Heini P, Windolf M, Schneider E (2007) Adjacent vertebral failure after vertebroplasty: a biomechanical study of low-modulus PMMA cement. Eur Spine J 16:2118–2125PubMedCrossRef
13.
go back to reference Calmels V, Vallee JN, Rose M, Chiras J (2007) Osteoblastic and mixed spinal metastases: evaluation of the analgesic efficacy of percutaneous vertebroplasty. AJNR Am J Neuroradiol 28:570–574PubMed Calmels V, Vallee JN, Rose M, Chiras J (2007) Osteoblastic and mixed spinal metastases: evaluation of the analgesic efficacy of percutaneous vertebroplasty. AJNR Am J Neuroradiol 28:570–574PubMed
14.
go back to reference Caudana R, Renzi BL, Ventura L, Aitini E, Rozzanigo U, Barai G (2008) CT-guided percutaneous vertebroplasty: personal experience in the treatment of osteoporotic fractures and dorsolumbar metastases. Radiol Med (Torino) 113:114–133. doi:10.1007/s11547-008-0230-1 CrossRef Caudana R, Renzi BL, Ventura L, Aitini E, Rozzanigo U, Barai G (2008) CT-guided percutaneous vertebroplasty: personal experience in the treatment of osteoporotic fractures and dorsolumbar metastases. Radiol Med (Torino) 113:114–133. doi:10.​1007/​s11547-008-0230-1 CrossRef
17.
go back to reference Chen LH, Niu CC, Yu SW, Fu TS, Lai PL, Chen WJ (2004) Minimally invasive treatment of osteoporotic vertebral compression fracture. Chang Gung Med J 27:261–267PubMed Chen LH, Niu CC, Yu SW, Fu TS, Lai PL, Chen WJ (2004) Minimally invasive treatment of osteoporotic vertebral compression fracture. Chang Gung Med J 27:261–267PubMed
18.
go back to reference Choe DH, Marom EM, Ahrar K, Truong MT, Madewell JE (2004) Pulmonary embolism of polymethyl methacrylate during percutaneous vertebroplasty and kyphoplasty. AJR Am J Roentgenol 183:1097–1102PubMed Choe DH, Marom EM, Ahrar K, Truong MT, Madewell JE (2004) Pulmonary embolism of polymethyl methacrylate during percutaneous vertebroplasty and kyphoplasty. AJR Am J Roentgenol 183:1097–1102PubMed
19.
go back to reference de Falco R, Scarano E, Di Celmo D, Grasso U, Guarnieri L (2005) Balloon kyphoplasty in traumatic fractures of the thoracolumbar junction. Preliminary experience in 12 cases. J Neurosurg Sci 49:147–153PubMed de Falco R, Scarano E, Di Celmo D, Grasso U, Guarnieri L (2005) Balloon kyphoplasty in traumatic fractures of the thoracolumbar junction. Preliminary experience in 12 cases. J Neurosurg Sci 49:147–153PubMed
21.
go back to reference Duran C, Sirvanci M, Aydogan M, Ozturk E, Ozturk C, Akman C (2007) Pulmonary cement embolism: a complication of percutaneous vertebroplasty. Acta Radiol 48:854–859PubMedCrossRef Duran C, Sirvanci M, Aydogan M, Ozturk E, Ozturk C, Akman C (2007) Pulmonary cement embolism: a complication of percutaneous vertebroplasty. Acta Radiol 48:854–859PubMedCrossRef
24.
go back to reference Galibert P, Deramond H, Rosat P, Le Gars D (1987) Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty. Neurochirurgie 33:166–168PubMed Galibert P, Deramond H, Rosat P, Le Gars D (1987) Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty. Neurochirurgie 33:166–168PubMed
27.
go back to reference Georgy BA (2007) Interventional techniques in managing persistent pain after vertebral augmentation procedures: a retrospective evaluation. Pain Phys 10:673–676 Georgy BA (2007) Interventional techniques in managing persistent pain after vertebral augmentation procedures: a retrospective evaluation. Pain Phys 10:673–676
28.
29.
32.
go back to reference Heffernan EJ, O’Sullivan PJ, Alkubaidan FO, Heran MK, Legiehn GM, Munk PL (2008) The current status of percutaneous vertebroplasty in Canada. Can Assoc Radiol J 59:77–82PubMed Heffernan EJ, O’Sullivan PJ, Alkubaidan FO, Heran MK, Legiehn GM, Munk PL (2008) The current status of percutaneous vertebroplasty in Canada. Can Assoc Radiol J 59:77–82PubMed
33.
go back to reference Hierholzer J, Depriester C, Fuchs H et al (2002) Percutaneous vertebroplasty. Rofo 174:328–334PubMed Hierholzer J, Depriester C, Fuchs H et al (2002) Percutaneous vertebroplasty. Rofo 174:328–334PubMed
34.
go back to reference Hierholzer J, Fuchs H, Westphalen K, Venz S, Pappert D, Depriester C (2005) Percutaneous vertebroplasty—the role of osseous phlebography. Rofo 177:386–392PubMed Hierholzer J, Fuchs H, Westphalen K, Venz S, Pappert D, Depriester C (2005) Percutaneous vertebroplasty—the role of osseous phlebography. Rofo 177:386–392PubMed
37.
go back to reference Jang JS, Lee SH (2005) Efficacy of percutaneous vertebroplasty combined with radiotherapy in osteolytic metastatic spinal tumors. J Neurosurg Spine 2:243–248PubMedCrossRef Jang JS, Lee SH (2005) Efficacy of percutaneous vertebroplasty combined with radiotherapy in osteolytic metastatic spinal tumors. J Neurosurg Spine 2:243–248PubMedCrossRef
39.
go back to reference Kaufmann TJ, Trout AT, Kallmes DF (2006) The effects of cement volume on clinical outcomes of percutaneous vertebroplasty. AJNR Am J Neuroradiol 27:1933–1937PubMed Kaufmann TJ, Trout AT, Kallmes DF (2006) The effects of cement volume on clinical outcomes of percutaneous vertebroplasty. AJNR Am J Neuroradiol 27:1933–1937PubMed
40.
41.
42.
go back to reference Kim YJ, Lee JW, Park KW et al (2009) Pulmonary cement embolism after percutaneous vertebroplasty in osteoporotic vertebral compression fractures: incidence, characteristics, and risk factors. Radiology 251:250–259. doi:10.1148/radiol.2511080854 PubMedCrossRef Kim YJ, Lee JW, Park KW et al (2009) Pulmonary cement embolism after percutaneous vertebroplasty in osteoporotic vertebral compression fractures: incidence, characteristics, and risk factors. Radiology 251:250–259. doi:10.​1148/​radiol.​2511080854 PubMedCrossRef
43.
44.
go back to reference Koyama M, Takizawa K, Kobayashi K et al (2005) Initial experience of percutaneous vertebroplasty using single-plane C-arm fluoroscopy for guidance. Radiat Med 23:256–260PubMed Koyama M, Takizawa K, Kobayashi K et al (2005) Initial experience of percutaneous vertebroplasty using single-plane C-arm fluoroscopy for guidance. Radiat Med 23:256–260PubMed
46.
go back to reference Layton KF, Thielen KR, Koch CA et al (2007) Vertebroplasty, first 1000 levels of a single center: evaluation of the outcomes and complications. AJNR Am J Neuroradiol 28:683–689PubMed Layton KF, Thielen KR, Koch CA et al (2007) Vertebroplasty, first 1000 levels of a single center: evaluation of the outcomes and complications. AJNR Am J Neuroradiol 28:683–689PubMed
47.
51.
go back to reference Lim SH, Kim H, Kim HK, Baek MJ (2008) Multiple cardiac perforations and pulmonary embolism caused by cement leakage after percutaneous vertebroplasty. Eur J Cardiothorac Surg 33:510–512PubMedCrossRef Lim SH, Kim H, Kim HK, Baek MJ (2008) Multiple cardiac perforations and pulmonary embolism caused by cement leakage after percutaneous vertebroplasty. Eur J Cardiothorac Surg 33:510–512PubMedCrossRef
52.
go back to reference Lin CC, Chen IH, Yu TC, Chen A, Yen PS (2007) New symptomatic compression fracture after percutaneous vertebroplasty at the thoracolumbar junction. AJNR Am J Neuroradiol 28:1042–1045. doi:10.3174/ajnr.A0520 PubMedCrossRef Lin CC, Chen IH, Yu TC, Chen A, Yen PS (2007) New symptomatic compression fracture after percutaneous vertebroplasty at the thoracolumbar junction. AJNR Am J Neuroradiol 28:1042–1045. doi:10.​3174/​ajnr.​A0520 PubMedCrossRef
55.
go back to reference Masala S, Mastrangeli R, Petrella MC, Massari F, Ursone A, Simonetti G (2008) Percutaneous vertebroplasty in 1,253 levels: results and long-term effectiveness in a single centre. Eur Radiol 19:165–171PubMedCrossRef Masala S, Mastrangeli R, Petrella MC, Massari F, Ursone A, Simonetti G (2008) Percutaneous vertebroplasty in 1,253 levels: results and long-term effectiveness in a single centre. Eur Radiol 19:165–171PubMedCrossRef
56.
go back to reference McDonald RJ, Trout AT, Gray LA, Dispenzieri A, Thielen KR, Kallmes DF (2008) Vertebroplasty in multiple myeloma: outcomes in a large patient series. AJNR Am J Neuroradiol 29:642–648. doi:10.3174/ajnr.A0918 PubMedCrossRef McDonald RJ, Trout AT, Gray LA, Dispenzieri A, Thielen KR, Kallmes DF (2008) Vertebroplasty in multiple myeloma: outcomes in a large patient series. AJNR Am J Neuroradiol 29:642–648. doi:10.​3174/​ajnr.​A0918 PubMedCrossRef
59.
go back to reference Mousavi P, Roth S, Finkelstein J, Cheung G, Whyne C (2003) Volumetric quantification of cement leakage following percutaneous vertebroplasty in metastatic and osteoporotic vertebrae. J Neurosurg 99:56–59PubMed Mousavi P, Roth S, Finkelstein J, Cheung G, Whyne C (2003) Volumetric quantification of cement leakage following percutaneous vertebroplasty in metastatic and osteoporotic vertebrae. J Neurosurg 99:56–59PubMed
60.
go back to reference Neuwirth J, Weber JC, Kohler B (2006) Pulmonary cement embolism after vertebroplasty in multiple osteoporotic vertebral fractures. Dtsch Med Wochenschr 131:2275–2276. doi:10.1055/s-2006-951363 CrossRef Neuwirth J, Weber JC, Kohler B (2006) Pulmonary cement embolism after vertebroplasty in multiple osteoporotic vertebral fractures. Dtsch Med Wochenschr 131:2275–2276. doi:10.​1055/​s-2006-951363 CrossRef
61.
go back to reference Noldge G, Da Fonseca K, Grafe I et al (2006) Balloonkyphoplasty in the treatment of back pain. Radiologe 46:506–512PubMedCrossRef Noldge G, Da Fonseca K, Grafe I et al (2006) Balloonkyphoplasty in the treatment of back pain. Radiologe 46:506–512PubMedCrossRef
62.
go back to reference Nussbaum DA, Gailloud P, Murphy K (2004) A review of complications associated with vertebroplasty and kyphoplasty as reported to the Food and Drug Administration medical device related web site. J Vasc Interv Radiol 15:1185–1192PubMed Nussbaum DA, Gailloud P, Murphy K (2004) A review of complications associated with vertebroplasty and kyphoplasty as reported to the Food and Drug Administration medical device related web site. J Vasc Interv Radiol 15:1185–1192PubMed
65.
go back to reference Padovani B, Kasriel O, Brunner P, Peretti-Viton P (1999) Pulmonary embolism caused by acrylic cement: a rare complication of percutaneous vertebroplasty. AJNR Am J Neuroradiol 20:375–377PubMed Padovani B, Kasriel O, Brunner P, Peretti-Viton P (1999) Pulmonary embolism caused by acrylic cement: a rare complication of percutaneous vertebroplasty. AJNR Am J Neuroradiol 20:375–377PubMed
66.
go back to reference Perrin C, Jullien V, Padovani B, Blaive B (1999) Percutaneous vertebroplasty complicated by pulmonary embolus of acrylic cement. Rev Mal Respir 16:215–217PubMed Perrin C, Jullien V, Padovani B, Blaive B (1999) Percutaneous vertebroplasty complicated by pulmonary embolus of acrylic cement. Rev Mal Respir 16:215–217PubMed
67.
69.
go back to reference Pitton MB, Herber S, Bletz C et al (2007) CT-guided vertebroplasty in osteoprotic vertebral fractures: incidence of secondary fractures and impact of intradiscal cement leakages during follow-up. Eur Radiol 18:43–50PubMedCrossRef Pitton MB, Herber S, Bletz C et al (2007) CT-guided vertebroplasty in osteoprotic vertebral fractures: incidence of secondary fractures and impact of intradiscal cement leakages during follow-up. Eur Radiol 18:43–50PubMedCrossRef
70.
go back to reference Pitton MB, Herber S, Koch U, Oberholzer K, Drees P, Duber C (2008) CT-guided vertebroplasty: analysis of technical results, extraosseous cement leakages, and complications in 500 procedures. Eur Radiol 18:2568–2578PubMedCrossRef Pitton MB, Herber S, Koch U, Oberholzer K, Drees P, Duber C (2008) CT-guided vertebroplasty: analysis of technical results, extraosseous cement leakages, and complications in 500 procedures. Eur Radiol 18:2568–2578PubMedCrossRef
72.
go back to reference Pott L, Wippermann B, Hussein S, Gunther T, Brusch U, Fremerey R (2005) PMMA pulmonary embolism and post interventional associated fractures after percutaneous vertebroplasty. Orthopade Pott L, Wippermann B, Hussein S, Gunther T, Brusch U, Fremerey R (2005) PMMA pulmonary embolism and post interventional associated fractures after percutaneous vertebroplasty. Orthopade
73.
go back to reference Purkayastha S, Gupta AK, Kapilamoorthy TR et al (2005) Percutaneous vertebroplasty in the management of vertebral lesions. Neurol India 53:167–173PubMed Purkayastha S, Gupta AK, Kapilamoorthy TR et al (2005) Percutaneous vertebroplasty in the management of vertebral lesions. Neurol India 53:167–173PubMed
76.
go back to reference Righini M, Sekoranja L, Le Gal G, Favre I, Bounameaux H, Janssens JP (2006) Pulmonary cement embolism after vertebroplasty. Thromb Haemost 95:388–389PubMed Righini M, Sekoranja L, Le Gal G, Favre I, Bounameaux H, Janssens JP (2006) Pulmonary cement embolism after vertebroplasty. Thromb Haemost 95:388–389PubMed
77.
go back to reference Schmidt R, Cakir B, Mattes T, Wegener M, Puhl W, Richter M (2005) Cement leakage during vertebroplasty: an underestimated problem? Eur Spine J 14:466–473PubMedCrossRef Schmidt R, Cakir B, Mattes T, Wegener M, Puhl W, Richter M (2005) Cement leakage during vertebroplasty: an underestimated problem? Eur Spine J 14:466–473PubMedCrossRef
79.
go back to reference Schoenes B, Bremerich DH, Risteski PS, Thalhammer A, Meininger D (2007) Cardiac perforation after vertebroplasty. Anaesthesist 57:147–150CrossRef Schoenes B, Bremerich DH, Risteski PS, Thalhammer A, Meininger D (2007) Cardiac perforation after vertebroplasty. Anaesthesist 57:147–150CrossRef
80.
go back to reference Scroop R, Eskridge J, Britz GW (2002) Paradoxical cerebral arterial embolization of cement during intraoperative vertebroplasty: case report. AJNR Am J Neuroradiol 23:868–870PubMed Scroop R, Eskridge J, Britz GW (2002) Paradoxical cerebral arterial embolization of cement during intraoperative vertebroplasty: case report. AJNR Am J Neuroradiol 23:868–870PubMed
81.
go back to reference Seo JS, Kim YJ, Choi BW, Kim TH, Choe KO (2005) MDCT of pulmonary embolism after percutaneous vertebroplasty. AJR Am J Roentgenol 184:1364–1365PubMed Seo JS, Kim YJ, Choi BW, Kim TH, Choe KO (2005) MDCT of pulmonary embolism after percutaneous vertebroplasty. AJR Am J Roentgenol 184:1364–1365PubMed
82.
go back to reference Serra L, Kermani FM, Panagiotopoulos K, De RV, Vizioli L (2007) Vertebroplasty in the treatment of osteoporotic vertebral fractures: results and functional outcome in a series of 175 consecutive patients. Minim Invasive Neurosurg 50:12–17. doi:10.1055/s-2006-947994 PubMedCrossRef Serra L, Kermani FM, Panagiotopoulos K, De RV, Vizioli L (2007) Vertebroplasty in the treatment of osteoporotic vertebral fractures: results and functional outcome in a series of 175 consecutive patients. Minim Invasive Neurosurg 50:12–17. doi:10.​1055/​s-2006-947994 PubMedCrossRef
83.
go back to reference Son KH, Chung JH, Sun K, Son HS (2008) Cardiac perforation and tricuspid regurgitation as a complication of percutaneous vertebroplasty. Eur J Cardiothorac Surg 33:508–509PubMedCrossRef Son KH, Chung JH, Sun K, Son HS (2008) Cardiac perforation and tricuspid regurgitation as a complication of percutaneous vertebroplasty. Eur J Cardiothorac Surg 33:508–509PubMedCrossRef
84.
86.
go back to reference Syed MI, Patel NA, Jan S, Harron MS, Morar K, Shaikh A (2005) New symptomatic vertebral compression fractures within a year following vertebroplasty in osteoporotic women. AJNR Am J Neuroradiol 26:1601–1604PubMed Syed MI, Patel NA, Jan S, Harron MS, Morar K, Shaikh A (2005) New symptomatic vertebral compression fractures within a year following vertebroplasty in osteoporotic women. AJNR Am J Neuroradiol 26:1601–1604PubMed
87.
go back to reference Tanigawa N, Komemushi A, Kariya S, Kojima H, Shomura Y, Sawada S (2005) Radiological follow-up of new compression fractures following percutaneous vertebroplasty. Cardiovasc Intervent Radiol 29:92–96CrossRef Tanigawa N, Komemushi A, Kariya S, Kojima H, Shomura Y, Sawada S (2005) Radiological follow-up of new compression fractures following percutaneous vertebroplasty. Cardiovasc Intervent Radiol 29:92–96CrossRef
88.
go back to reference Torres Machi ML, Suarez RV, Medina RC, Gil BF, Ojeda BN, Rodriguez-Perez A (2003) Pulmonary embolism caused by cement following vertebroplasty. Rev Esp Anestesiol Reanim 50:489–491PubMed Torres Machi ML, Suarez RV, Medina RC, Gil BF, Ojeda BN, Rodriguez-Perez A (2003) Pulmonary embolism caused by cement following vertebroplasty. Rev Esp Anestesiol Reanim 50:489–491PubMed
90.
go back to reference Trout AT, Gray LA, Kallmes DF (2005) Vertebroplasty in the inpatient population. AJNR Am J Neuroradiol 26:1629–1633PubMed Trout AT, Gray LA, Kallmes DF (2005) Vertebroplasty in the inpatient population. AJNR Am J Neuroradiol 26:1629–1633PubMed
91.
go back to reference Venmans A, Lohle PN, van Rooij WJ, Verhaar HJ, Mali WP (2008) Frequency and outcome of pulmonary polymethylmethacrylate embolism during percutaneous vertebroplasty. AJNR Am J Neuroradiol 29:1983–1985. doi:10.3174/ajnr.A1269 PubMedCrossRef Venmans A, Lohle PN, van Rooij WJ, Verhaar HJ, Mali WP (2008) Frequency and outcome of pulmonary polymethylmethacrylate embolism during percutaneous vertebroplasty. AJNR Am J Neuroradiol 29:1983–1985. doi:10.​3174/​ajnr.​A1269 PubMedCrossRef
93.
go back to reference Wong W, Reiley MA, Garfin S (2000) Vertebroplasty/kyphoplasty. J Womens Imaging 2:117–124 Wong W, Reiley MA, Garfin S (2000) Vertebroplasty/kyphoplasty. J Womens Imaging 2:117–124
Metadata
Title
Management of pulmonary cement embolism after percutaneous vertebroplasty and kyphoplasty: a systematic review of the literature
Authors
Antonio Krueger
Christopher Bliemel
Ralph Zettl
Steffen Ruchholtz
Publication date
01-09-2009
Publisher
Springer-Verlag
Published in
European Spine Journal / Issue 9/2009
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI
https://doi.org/10.1007/s00586-009-1073-y

Other articles of this Issue 9/2009

European Spine Journal 9/2009 Go to the issue