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01-10-2019 | Original Article

Effect of zinc on erythrocyte osmotic fragility and hemogram following chronic exposure to glyphosate-based herbicide in Wistar rats

Authors: Emmanuel Vandi Tizhe, Najume Dogon-Giginya Ibrahim, Mohammed Yakasai Fatihu, Suleiman Folorunsho Ambali, Ikechukwu Onyebuchi Igbokwe, Delia Ussa Tizhe

Published in: Comparative Clinical Pathology | Issue 5/2019

Abstract

The study was conducted to assess the effect of zinc on erythrocyte osmotic fragility and hemogram of rats following chronic oral exposure to glyphosate-based herbicide (BUSHFIRE®) at daily doses of 14.4–750 mg/kg of glyphosate. The erythrocyte osmotic fragility, estimated as percentage hemolysis in hypotonic saline, was significantly (p < 0.05) increased in glyphosate-exposed groups at 0.5–0.9% NaCl concentrations, and the fragility was ameliorated in the groups with zinc pretreatments only at 0.5% NaCl. The toxicity did not have any significant effect on the packed cell volume and other erythrocyte parameters. There was significant (p < 0.05) decrease in total white blood cell and lymphocyte counts in glyphosate-exposed groups, which was absent in zinc-pretreated groups. In conclusion, increased erythrocyte osmotic fragility induced by glyphosate could be prevented following zinc pretreatment, but the altered leukogram caused by the toxic action was not fully ameliorated in the pretreated group.

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Title: Effect of zinc on erythrocyte osmotic fragility and hemogram following chronic exposure to glyphosate-based herbicide in Wistar rats
Authors: Emmanuel Vandi Tizhe
Najume Dogon-Giginya Ibrahim
Mohammed Yakasai Fatihu
Suleiman Folorunsho Ambali
Ikechukwu Onyebuchi Igbokwe
Delia Ussa Tizhe
Publication date: 01-10-2019
Publisher: Springer London
Published in: Comparative Clinical Pathology / Issue 5/2019
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-019-02917-y

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Effect of zinc on erythrocyte osmotic fragility and hemogram following chronic exposure to glyphosate-based herbicide in Wistar rats

Abstract

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Abstract

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