Local anesthetic systemic toxicity: proposed mechanisms for lipid resuscitation and methods of prevention

Excerpt

“Practical guide for the management of systemic toxicity caused by local anesthetics” has been published by the Japanese Society of Anesthesiologists [1]. This guide addresses anesthetic management performed by members of our society and can also be referenced during any procedure performed in Japan including the use of local anesthetics. I believe that this guide would contribute to the improvement and progress of anesthesia practice. Although local anesthetic systemic toxicity is a fatal complication, its detailed mechanisms have not been fully elucidated. Recently, several new findings have been reported concerning its toxicity and resuscitation by lipid emulsion. Hereby, I briefly summarize the investigations currently in progress and refer to the methods developed to prevent local anesthetic systemic toxicity. …