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Journal of Anesthesia
Published in: Journal of Anesthesia 1/2018

01-02-2018 | Original Article

Evaluation of pharmacokinetic models of intravenous dexmedetomidine in sedated patients under spinal anesthesia

Authors: Shinju Obara, Tsuyoshi Imaizumi, Takahiro Hakozaki, Atsuyuki Hosono, Yuzo Iseki, Norie Sanbe, Masahiro Murakawa

Published in: Journal of Anesthesia | Issue 1/2018

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Abstract

Purpose

Little information is available on the predictive ability of previously published pharmacokinetic models of dexmedetomidine in patients under spinal anesthesia. We evaluated nine published pharmacokinetic models that were constructed in different study settings.

Methods

Sixteen patients received dexmedetomidine infusions after spinal anesthesia according to the manufacturer’s recommended regimen (6 µg/kg/h over 10 min followed by 0.2–0.7 µg/kg/h) or target-controlled infusion (initial target of 1.5 ng/ml using the Dyck model). Dexmedetomidine concentrations were measured and median performance error (MDPE), median absolute performance error (MDAPE), and wobble were calculated.

Results

A total of 84 blood samples were analyzed. The pharmacokinetic model reported by Hannivoort et al. had the greatest ability to predict dexmedetomidine concentrations (MDPE 5.6%, MDAPE 18.1%, and wobble 6.2%).

Conclusions

Hannivoort et al.’s pharmacokinetic model, constructed with a dataset obtained from healthy volunteers, can predict dexmedetomidine concentrations best during continuous infusion under spinal anesthesia.
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Metadata
Title
Evaluation of pharmacokinetic models of intravenous dexmedetomidine in sedated patients under spinal anesthesia
Authors
Shinju Obara
Tsuyoshi Imaizumi
Takahiro Hakozaki
Atsuyuki Hosono
Yuzo Iseki
Norie Sanbe
Masahiro Murakawa
Publication date
01-02-2018
Publisher
Springer Japan
Published in
Journal of Anesthesia / Issue 1/2018
Print ISSN: 0913-8668
Electronic ISSN: 1438-8359
DOI
https://doi.org/10.1007/s00540-017-2424-1

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