Published in:
01-06-2018 | Letter to the Editor
Reply to the letter to the editor: Lymph node metastasis of adenocarcinoma and different definitions of sm1 cancer in the esophagus
Published in: Journal of Gastroenterology | Issue 6/2018
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Thank you for your very helpful comments. We totally understand Dr. Takubo’s points. The diagnosis of cancer invasion depth may differ substantially between surgical specimen which is cut into 5-mm slices and endoscopic resected specimen which is cut into 2-mm slices. This difference may lead to misinterpretation of metastatic rate. We therefore show individual data of surgical specimens and endoscopic resected specimens in Tables 1 and 2.
Table 1
Rate of metastasis in surgical specimens
|
LVI (−) and poorly comp (−)
|
LVI (+) or poorly comp (+)
|
||
|---|---|---|---|
|
≤ 3 cm
|
3 cm <
|
||
|
SMM
|
0% (0/13 lesions)
|
0% (0/1 lesions)
|
0% (0/0 lesions)
|
|
LPM
|
0% (0/10 lesions)
|
0% (0/4 lesions)
|
0% (0/0 lesions)
|
|
DMM
|
0% (0/15 lesions)
|
0% (0/3 lesions)
|
83.3% (5/6 lesions)
|
|
SM 1–500 µm
|
0% (0/8 lesions)
|
0% (0/5 lesions)
|
30% (3/10 lesions)
|
|
SM 500 µm
|
9.5% (2/21 lesions)
|
23.1% (3/13 lesions)
|
40.7% (44/108 lesions)
|
Table 2
Rate of metastasis in endoscopic resected specimens
|
LVI (−) and poorly comp (−)
|
LVI (+) or poorly comp (+)
|
||
|---|---|---|---|
|
≤ 3 cm
|
3 cm <
|
||
|
SMM
|
0% (0/31 lesions)
|
0% (0/5 lesions)
|
0% (0/1 lesions)
|
|
LPM
|
0% (0/31 lesions)
|
0% (0/3 lesions)
|
0% (0/2 lesions)
|
|
DMM
|
0% (0/67 lesions)
|
0% (0/3 lesions)
|
44.4% (4/9 lesions)
|
|
SM 1–500 µm
|
0% (0/24 lesions)
|
25.0% (1/4 lesions)
|
0% (0/8 lesions)
|
|
SM 500 µm
|
7.1% (1/14 lesions)
|
20.0% (1/5 lesions)
|
23.5(8/34 lesions)
|